What is already known: Erector spinae plane block (ESPB) is an ultrasound-guided nerve block that has shown effectiveness in treating visceral and somatic pain.What is new in the current study: Our review provides support for ESPB in the management of intractable, non-surgical abdominal pain. ESPB demonstrates efficacy in alleviating various conditions such as functional abdominal pain, renal colic, pancreatitis, herpetic pain, and cancer-related pain.