The first antivascular endothelial growth factor (anti-VEGF) was developed as an anticancer drug
for colonic carcinomas. Since then, anti-VEGFs have developed in scope and indications. They have
revolutionized the treatment of exudative macular degeneration and have had a major impact on
treatment of several other conditions. This has resulted in an increased number of patients seeking
treatment with new treatment options and has had a considerable financial impact on health care
resources. Anti-VEGFs have been used in the treatment of all age groups of the population ranging
from infants where it is used for treatment of retinopathy of prematurity to the elderly where it is
used in exudative macular eegeneration.