Erfolgskontrolle und Lebensqualität nach Myomembolisation: Langzeitergebnisse

Hirzel, Florian C.; Heß, Thomas; Zollikofer, Christoph L.

doi:10.1159/000118936

Cited by 3 publications

(2 citation statements)

References 52 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is very plausible that they were not relieved of symptoms and opted to seek other modalities of treatment. The improvement in HRQL and decline in SS in response to EGCG treatment was comparable to a study conducted by Hirzel et al52 to see the impact of uterine artery embolization on quality of life among symptomatic fibroid patients. The advantage of this oral intervention, however, would be the avoidance of possible side effects of uterine artery embolization, such as uterine necrosis and increased rate of surgical reintervention 53,54.…”

Section: Discussionsupporting

confidence: 83%

Treatment of symptomatic uterine fibroids with green tea extract: a pilot randomized controlled clinical study

Roshdy¹,

Rajaratnam²,

Maitra³

et al. 2013

IJWH

View full text Add to dashboard Cite

BackgroundUterine fibroids (UFs, also known as leiomyoma) affect 70% of reproductive-age women. Imposing a major burden on health-related quality-of-life (HRQL) of premenopausal women, UF is a public health concern. There are no effective medicinal treatment options currently available for women with symptomatic UF.ObjectivesTo evaluate the efficacy and safety of green tea extract (epigallocatechin gallate [EGCG]) on UF burden and quality of life in women with symptomatic UF, in a double-blinded, placebo-controlled randomized clinical trial.MethodsA total of 39 reproductive-age women (age 18–50 years, day 3 serum follicle-stimulating hormone <10 \U/mL) with symptomatic UF were recruited for this study. All subjects had at least one fibroid lesion 2 cm3 or larger, as confirmed by transvaginal ultrasonography. The subjects were randomized to oral daily treatment with either 800 mg of green tea extract (45% EGCG) or placebo (800 mg of brown rice) for 4 months, and UF volumes were measured at the end, also by transvaginal ultrasonography. The fibroid-specific symptom severity and HRQL of these UF patients were scored at each monthly visit, using the symptom severity and quality-of-life questionnaires. Student’s t-test was used to evaluate statistical significance of treatment effect between the two groups.ResultsOf the final 39 women recruited for the study, 33 were compliant and completed all five visits of the study. In the placebo group (n = 11), fibroid volume increased (24.3%) over the study period; however, patients randomized to green tea extract (n = 22, 800 mg/day) treatment showed significant reduction (32.6%, P = 0.0001) in total UF volume. In addition, EGCG treatment significantly reduced fibroid-specific symptom severity (32.4%, P = 0.0001) and induced significant improvement in HRQL (18.53%, P = 0.01) compared to the placebo group. Anemia also significantly improved by 0.7 g/dL (P = 0.02) in the EGCG treatment group, while average blood loss significantly decreased from 71 mL/month to 45 mL/month (P = 0.001). No adverse effects, endometrial hyperplasia, or other endometrial pathology were observed in either group.ConclusionEGCG shows promise as a safe and effective therapeutic agent for women with symptomatic UFs. Such a simple, inexpensive, and orally administered therapy can improve women’s health globally.

show abstract

Section: Discussionsupporting

confidence: 83%

Treatment of symptomatic uterine fibroids with green tea extract: a pilot randomized controlled clinical study

Roshdy¹,

Rajaratnam²,

Maitra³

et al. 2013

IJWH

View full text Add to dashboard Cite

show abstract

“…A significant improvement in OABSS and ICIQ-SF (International Consultation on Incontinence Modular Questionnaire, Short Form) scores was seen at 3 months after high-intensity focused ultrasonography (n5404) 27 and 6 weeks after hysterectomy or myomectomy (n555). 30 Urinary frequency during the day and night, as measured on the UFS-QOL, decreased 34 months after uterine artery embolization in a single-group retrospective study (n534) 35 (Appendix 2, http://links.lww.com/AOG/D227).…”

Section: Resultsmentioning

confidence: 99%

Changes in Pelvic Floor Symptoms After Procedural Interventions for Uterine Leiomyomas

Gupta

Balk

Lenger

et al. 2023

Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

OBJECTIVE: To conduct a systematic review to evaluate the effect of procedural interventions for leiomyomas on pelvic floor symptoms. DATA SOURCES: PubMed, EMBASE, and ClinicalTrials.gov were searched from inception to January 12, 2023, searching for leiomyoma procedures and pelvic floor disorders and symptoms, restricted to primary study designs in humans. METHODS OF STUDY SELECTION: Double independent screening for studies of any study design in all languages that reported pelvic floor symptoms before and after surgical (hysterectomy, myomectomy, radiofrequency volumetric thermal ablation) or radiologic (uterine artery embolization, magnetic resonance-guided focused ultrasonography, high-intensity focused ultrasonography) procedures for management of uterine leiomyomas. Data were extracted, with risk-of-bias assessment and review by a second researcher. Random effects model meta-analyses were conducted, as feasible. TABULATION, INTEGRATION, AND RESULTS: Six randomized controlled trials, one nonrandomized comparative study, and 25 single-group studies met criteria. The overall quality of the studies was moderate. Only six studies, reporting various outcomes, directly compared two procedures for leiomyomas. Across studies, leiomyoma procedures were associated with decreased symptom distress per the UDI-6 (Urinary Distress Inventory, Short Form) (summary mean change −18.7, 95% CI −25.9 to −11.5; six studies) and improved quality of life per the IIQ-7 (Incontinence Impact Questionnaire, Short Form) (summary mean change −10.7, 95% CI −15.8 to −5.6; six studies). There was a wide range of resolution of urinary symptoms after procedural interventions (7.6–100%), and this varied over time. Urinary symptoms improved in 19.0–87.5% of patients, and the definitions for improvement varied between studies. Bowel symptoms were inconsistently reported in the literature. CONCLUSION: Urinary symptoms improved after procedural interventions for uterine leiomyomas, although there is high heterogeneity among studies and few data on long-term outcomes or comparing different procedures. SYSTEMATIC REVIEW REGISTRATION: PROSPERO, CRD42021272678.

show abstract

Long-term results of symptomatic fibroids treated with uterine artery embolization: In conjunction with MR evaluation

Kim¹,

Lee²,

Lee³

et al. 2010

European Journal of Radiology

View full text Add to dashboard Cite

Erfolgskontrolle und Lebensqualität nach Myomembolisation: Langzeitergebnisse

Cited by 3 publications

References 52 publications

Treatment of symptomatic uterine fibroids with green tea extract: a pilot randomized controlled clinical study

Treatment of symptomatic uterine fibroids with green tea extract: a pilot randomized controlled clinical study

Changes in Pelvic Floor Symptoms After Procedural Interventions for Uterine Leiomyomas

Long-term results of symptomatic fibroids treated with uterine artery embolization: In conjunction with MR evaluation

Contact Info

Product

Resources

About