ERG in Diabetics

Simonsen, Svend Erik

doi:10.1159/000388654

Cited by 17 publications

(15 citation statements)

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“…This is not surprising given that diabetes impacts on most cell types in the body, but it is potentially very important because the neural and glial cells appear to be affected very early on in the course of diabetes, and could thus claim a causative or contributory role in the microangiopathy. Reports of electroretinographic changes in diabetic patients without demonstrable vascular lesions date back to the 1960 s [6] and have been confirmed by several authors, who found the electroretinographic abnormalities to originate in the ganglion and inner nuclear layers [7,8]. Studies mostly performed in streptozotocin-induced diabetic rats have now identified specific molecular changes of neuroglial elements in these retinal layers very early after induction of diabetes.…”

Section: Multiple Cell Types In the Retina Are Affected By Diabetesmentioning

confidence: 82%

Early cellular and molecular changes induced by diabetes in the retina

2001

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Section: Multiple Cell Types In the Retina Are Affected By Diabetesmentioning

confidence: 82%

Early cellular and molecular changes induced by diabetes in the retina

2001

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“…It was not until 1953 that Cobb and Morton described four to six smaller wavelets superimposed on the b-wave of the human ERG. Since then the clinical importance of the OPs have been reported by several investigators for example Yonemura andassociates (1962, 1978), Simonsen (1965Simonsen ( , 1968, Algvere (1968), Speros & Price (1981), Bresnick and associates (1984), and many others.…”

Section: Introductionmentioning

confidence: 94%

“…Since the publication by Yonemura and associates in 1962, many studies have described alterations of the OPs in diabetes mellitus (Simonsen, 1965(Simonsen, , 1968Algvere, 1968;Brunette & Desrochers, 1970;Galloway et al, 1972;Gj6tterberg, 1974). Severely reduced or abolished OPs were found in cases with advanced diabetic retinopathy.…”

Section: Ill Clinical Importance Of the Oscillatory Potentialsmentioning

confidence: 99%

Basic research and clinical aspects of the oscillatory potentials of the electroretinogram

Wachtmeister

1987

Doc Ophthalmol

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This paper reviews current knowledge concerning the oscillatory potentials (OPs) of the electroretinogram (ERG). The first section describes the basic characteristics of the OPs primarily studied in healthy subjects. The behavior of the OPs is different from the a- and b-waves, indicating separate mechanisms for generation of the OPs compared with the major components of the ERG. The second section deals with the present view of the origin of the OPs collected from experimental studies of the vertebrate retina, including the primate. Findings favor the conclusion that the bipolar (or interplexiform) cells are the probable generators of the OPs. The third section gives clinical examples of the sensitivity of OPs to early disturbances of retinal function in different eye diseases.

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“…Muller (glial) cells of the retina show damage due to diabetes mellitus earlier than the retinal blood vessels (Simonsen, 1968) and the b-wave of the ERG is known to be related to Muller cell function (Miller & Dowling, 1970;Tamai & Tanaka, 1973;Fujimoto & Tomita, 1981;Newman & Odette, 1984). Among the alterations of the b-wave, the latency shows more significant changes than the amplitude in rats with early diabetes (Kozak, Deneault & Rogowska, 1983;Sato, Sugimoto, Ando, Miyajima & Chiba, 1984).…”

Section: Introductionmentioning

confidence: 99%

Effect of an aldose reductase inhibitor, SNK‐860, on deficits in the electroretinogram of diabetic rats

Hotta

Koh

Sakakibara

et al. 1995

Experimental Physiology

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SUMMARYTo determine the effect of an aldose reductase inhibitor, SNK-860, on the worsening of the electroretinogram (ERG) during a diabetic state, rats with streptozotocin-induced diabetes were administered SNK-860 (1 or 4 mg kg-' orally) daily for 4 weeks. The effectiveness of SNK-860 in prolonging the peak latencies of oscillatory potentials in the b-wave of the electroretinogram of diabetic rats varied between these different waveform components (designated O1, 02 and 03). SNK-860 (4 mg kg-' day-') either completely or partially prevented the prolonged peak latencies at 01 and (0°1 + 02 + 03). The drug failed to shorten the latency of the 02 and 03 components, and produced only a modest reduction in retinal levels of sorbitol and fructose, with no increase in myo-inositol. There was a significant correlation between the state of the ERG (components 0, and X(01 + 02 + 03)) and the retinal levels of sorbitol and fructose (P < 0.01), but not of myo-inositol.It is concluded that a better understanding of the mechanism by which SNK-860 acts may provide new insight into the pathogenesis of hyperglycaemic retinal dysfunction and help to establish effective therapy for diabetic retinopathy.

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ERG in Diabetics

Cited by 17 publications

References 0 publications

Early cellular and molecular changes induced by diabetes in the retina

Early cellular and molecular changes induced by diabetes in the retina

Basic research and clinical aspects of the oscillatory potentials of the electroretinogram

Effect of an aldose reductase inhibitor, SNK‐860, on deficits in the electroretinogram of diabetic rats

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