Ergogenic Drugs in Sports

Knopp, William D.; Wang, Thomas W.; Bach, Bernard R.

doi:10.1016/s0278-5919(05)70031-4

Cited by 16 publications

(14 citation statements)

References 36 publications

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“…A wide range of hepatotoxic effects of androgenic anabolic steroids have been described including cholestasis, peliosis hepatis and hepatic neoplasm (Johnson et al, 1972; Nadell and Kosek, 1977; Ishak, 1979; Turani et al, 1983; Wakabayashi et al., 1984; Sheffer et al, 1987; Creagh et al, 1988; Graham and Kennedy, 1990; Soe et al, 1992; Dossing and Sonne, 1993; Gurakar et al, 1994; Yosida et al, 1994; Handelsman, 1995; Knopp et al, 1997; Chitturi and Farrel, 2001). Especially, 17α‐alkylated androgens are known for inducing cholestasis (Stang‐Vos and Appell, 1981), resulting in reduced biliary excretion of bile acids.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis in Growth Promoter Treated Cows

Groot

2002

Journal of Veterinary Medicine Series A

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Adult female beef cattle found positive for stanozolol in the urine were investigated for liver pathology. In all the animals toxic hepatitis was found, including cholestasis, periportal fibrosis and inflammation, focal necrosis and blood filled lacunae. As no clinical data of the cows were available, apart from the history of illegal stanozolol abuse, it is not possible to attribute all changes to the illegal hormone treatment. Moreover, the cows have probably been treated with a cocktail, and apart from stanozolol more anabolic steroids may have been used. Management factors, viral and bacterial infections, former caesarean sections and especially feeding regime may also be responsible for the lesions described. Striking similarities with data from hepatotoxicity found in human body builders using similar agents, however, suggest a major role of stanozolol as causative agent.

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Section: Discussionmentioning

confidence: 99%

Hepatitis in Growth Promoter Treated Cows

Groot

2002

Journal of Veterinary Medicine Series A

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“…Steroid use has gained widespread public attention in recent years, owing to news of abuse by high-profile athletes in professional and Olympic sports. 1,2 Hundreds of thousands of Americans are estimated to be abusing these drugs, mostly in secret. Incidents of violent, aggressive, and even homicidal behavior have added notoriety to this topic.…”

Section: ■ Steroid Abuse Is Not Newmentioning

confidence: 99%

“…The US Drug Enforcement Agency controls and monitors their use. 1,5 sport are involved in allegations of anabolicandrogenic steroid use. The current media exposure might reflect an increased prevalence and penetration of steroid use in sports culture.…”

Section: ■ Steroid Abuse Is Not Newmentioning

confidence: 99%

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Anabolic steroid abuse: psychiatric and physical costs.

Talih¹,

Fattal²,

Malone³

2007

Cleveland Clinic Journal of Medicine

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The psychiatric effects of anabolic-androgenic steroids (ie, testosterone and its derivatives) have been less well studied than their physical effects but are reported to include depression, mania, psychosis, and aggression. Dependence can also occur, with withdrawal involving psychiatric and physical symptoms. Adverse effects of steroid abuse should be managed by discontinuing the drugs-by tapering if necessary-and by treating the symptoms.

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“…The most common classes of doping drugs include not only illicit substances but also products sold as nutritional supplements. Anabolic steroids, peptide hormones, stimulants such as amphetamine, cocaine, caffeine, or ephedrine, narcotic analgesics and diuretics, among others [61]. Mass spectrometry (MS)-chromatographic techniques are currently mostly used for the determination of doping substances.…”

Section: Dopingmentioning

confidence: 99%

What Electrochemical Biosensors Can Do for Forensic Science? Unique Features and Applications

et al. 2019

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This article critically discusses the latest advances in the use of voltammetric, amperometric, potentiometric, and impedimetric biosensors for forensic analysis. Highlighted examples that show the advantages of these tools to develop methods capable of detecting very small concentrations of analytes and provide selective determinations through analytical responses, without significant interferences from other components of the samples, are presented and discussed, thus stressing the great versatility and utility of electrochemical biosensors in this growing research field. To illustrate this, the determination of substances with forensic relevance by using electrochemical biosensors reported in the last five years (2015–2019) are reviewed. The different configurations of enzyme or affinity biosensors used to solve analytical problems related to forensic practice, with special attention to applications in complex samples, are considered. Main prospects, challenges to focus, such as the fabrication of devices for rapid analysis of target analytes directly on-site at the crime scene, or their widespread use and successful applications to complex samples of interest in forensic analysis, and future efforts, are also briefly discussed.

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Ergogenic Drugs in Sports

Cited by 16 publications

References 36 publications

Hepatitis in Growth Promoter Treated Cows

Hepatitis in Growth Promoter Treated Cows

Anabolic steroid abuse: psychiatric and physical costs.

What Electrochemical Biosensors Can Do for Forensic Science? Unique Features and Applications

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