Due to the rapid spread of COVID-19, some of the major preventive measures such as complete lockdown of the country with the availability of only essential services that lead to a lot of changes in people's daily lifestyle and work pattern. The mobile device has had a significant impact on everyday life in all ages and in almost of the countries. The average time reported spent on internet use was 2.13 hours every day in the Indian population. Mobile device users complain of discomfort in at least one area of the upper extremities, upper back, or neck pain, shoulder pain, wrist and hand pain, and finger discomfort. Long-term use of smartphones causes continuous mechanical stress on the tendons, muscles, and perimetric tissue, which can induce various musculoskeletal symptoms. The use of smartphones in a sitting position may lead to more shift in head-neck angle than in a standing position. The main aim of this article is to understand the overview of musculoskeletal check during this time of lockdown, where we all have to experience changes in our lifestyle pattern by staying indoors. So the overview of this article is concluded by giving a scientific understanding behind keeping a musculoskeletal check in smartphone overuse in lockdown phase, which is of great importance to optimize, maintain & improve the overall performance of the body.