Ergosterol exerts a differential effect on AR-dependent LNCaP and AR-independent DU-145 cancer cells

Dysregulation of the miRNome unveils a crosstalk between obesity and prostate cancer: miR-107 asa personalized diagnostic and therapeutic tool

“…These results obtained from androgen-dependent versus androgen-independent PCa cells have not been reported before and suggest the idea that miR-107 could play a different endogenous role in PCa cells, depending on the degree of tumor aggressiveness, maybe due to the sophisticated molecular mechanism of regulation of miRNAs in different cell types. 5 Therefore, although differential responses in androgendependent versus androgen-independent PCa cells have been previously reported, [32][33][34] this particular phenomenon observed in our study warrants further investigation in order to unveil its clinical implication.…”

Potential Beneficial Effects and Pharmacological Properties of Ergosterol, a Common Bioactive Compound in Edible Mushrooms

“…The suppression of bladder carcinogenesis may be attributed to the antagonistic effect of brassicasterol on androgen receptors, owing to its structural similarity to testosterone [ 83 ]. In silico analysis revealed that ergosterol shows an interaction similar to that of 5α-dihydrotestosterone and testosterone in the binding mode with androgen receptors during a molecular dynamic simulation [ 84 ]. Therefore, ergosterol is particularly effective against sex-hormone-dependent cancers.…”

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

“…That is why ergosterol itself has attracted considerable attention as a potential lead for the development of new therapeutics. Its anticancer properties were investigated on the lungs [ 39 ], liver [ 40 , 41 ], breast [ 42 ], human gastric [ 43 ], and prostate [ 44 ] cancer cell lines.…”

“…Different effects have been noted for androgen-dependent LNCaP and androgen-independent DU-145 prostate cancer cells [ 44 ]. While ergosterol exerted an antiproliferative action on LNCaP, it promoted cell proliferation on DU-145.…”

“…While ergosterol exerted an antiproliferative action on LNCaP, it promoted cell proliferation on DU-145. The authors [ 44 ] suggested that the observed difference may be related to the ability of ergosterol to act as a ligand for the androgen receptor.…”