Ergotamine- and Analgesic-Induced Headaches

Henry, P; Jf, Dartigues; Benetier, M.P.; Lucas, J.; Duplan, B.; M, Jogeix; Orgogozo, J. M.

doi:10.1159/000411509

Cited by 17 publications

(23 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Withdrawal headache is often accompanied by important vegetative symptoms that are worse on the third and fourth day after discontinuation of medication. After this difficult period, most patients experience considerable clinical improvement with reduced headache intensity and frequency 6,9,11 . A similar course has been described in patients withdrawing abruptly from ergotamine 9 …”

mentioning

confidence: 66%

See 1 more Smart Citation

Behavioral and Pharmacologic Treatment of Transformed Migraine With Analgesic Overuse: Outcome at 3 Years

Grazzi¹,

Andrasik

D’Amico³

et al. 2002

Headache

160

120

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 66%

“…Patients with chronic headache and analgesic overuse are difficult to treat for several reasons. First, they often show signs of physical and emotional dependence and some form of psychological involvement 4,6,7 . Second, prophylactic medications that otherwise are often effective will rarely benefit these individuals 6,8‐10 .…”

mentioning

confidence: 99%

Behavioral and Pharmacologic Treatment of Transformed Migraine With Analgesic Overuse: Outcome at 3 Years

Grazzi¹,

Andrasik

D’Amico³

et al. 2002

Headache

160

120

View full text Add to dashboard Cite

show abstract

“…Although ergotamine and analgesics are valuable drugs for the treatment of acute migraine attacks, 1 their chronic and daily use bears serious side effects, among them drug-induced headaches. [2][3][4][5][6][7][8][9] Originally, drug-induced headaches were thought to be caused by ergotamine components of pain relievers and therefore termed ergotamine headaches. 8,[10][11][12][13][14][15] Recent studies, however, have shown that a similar form of headache is caused by chronic use of analgesics without ergotamine components and therefore the terms analgesic-induced or drug-induced headaches should be preferred.…”

Section: Introductionmentioning

confidence: 99%

Longterm Prognosis of Analgesic Withdrawal in Patients with Drug‐Induced Headaches

Baumgartner¹,

Wessely²,

Bingöl³

et al. 1989

Headache

134

106

View full text Add to dashboard Cite

We studied long-term prognosis and prognostic variables for therapeutic outcome of analgesic withdrawal in 54 patients with drug-induced headaches. The duration of headache history was 21.9 +/- 12.8 years. Each patient took an average of 38.8 +/- 22.8 tablets or suppositories a week and an average of 2.5 distinct drugs. Most patients used drugs containing several components. Caffeine was contained in at least one drug in all cases, ergotamine in 80.0% and pyrazolone in 77.1%. All patients were admitted to the hospital for two weeks. The analgesics were discontinued abruptly and the withdrawal symptoms were alleviated by neuroleptics and neurotropics. During the second week of hospital stay we started a basic therapy with calcium antagonists or beta blockers in patients suffering from migraine initially and with tricyclic antidepressants, physical therapy or biofeedback in patients suffering from tension type headaches initially. At the end of the study (mean follow-up period = 16.8 +/- 13.6 months) 38 patients (70.1%) were evaluated. 76.3% of these patients had significantly reduced their analgesic intake, 60.5% had experienced a significant relief of headache both in intensity and frequency, and 23.7% were therapeutic failures. Analysis of the time course of relapse revealed the first six months after hospital discharge as the critical period determining long-term success. The variables tested for prognostic relevance (age, sex, duration of headache history, number of tablets or suppositories taken a week, organic mental syndrome, and type of initial headaches) were not statistically significant.

show abstract

“…However, in later studies it was realized that also the chronic abuse of analgesics and other psycho tropic drugs could lead to drug-induced daily headache and that only consequent withdrawal therapy was able to reduce headache frequency and intensity (3)(4)(5)(6)(7)(8)(9)(10). In the first observations on chronic drug-induced headache, only ergotamine was assumed to cause this phenomenon (1, 2).…”

mentioning

confidence: 99%

Drug-Induced Headache: Long-Term Results of Stationary Versus Ambulatory Withdrawal Therapy

Suhr¹,

Evers²,

Bauer

et al. 1999

Cephalalgia

View full text Add to dashboard Cite

Drug-induced headache is a well-known complication of the treatment of primary headache disorders, and its successful management is only possible by withdrawal therapy. However, it is unknown whether ambulatory or stationary withdrawal is the therapy preferred. We conducted a prospective study on the outcome of stationary versus ambulatory withdrawal therapy in patients with drug-induced headache according to the International Headache Society criteria. Out of 257 patients with the diagnosis of drug-induced headache during the study period, 101 patients (41 after ambulatory and 60 after stationary withdrawal therapy) could be followed up for 5.9 +/- 4.0 years. The total relapse rate after successful withdrawal therapy was 20.8% (14.6% after ambulatory and 25.0% after stationary withdrawal therapy, p < 0.2). The main risk factors for a relapse were male sex (OR = 3.9, CI = 1.3-11.6), intake of combined analgesic drugs (OR = 3.8, CI = 1.4-10.3), administration of naturopathy (OR = 6.0, CI = 1.2-29.3), and a trend to tension-type headache as the primary headache disorder (OR = 1.9, CI = 0.6-53.0). Our data suggest that neither the method of withdrawal therapy nor the kind of analgesic and other antimigraine drugs has a major impact on the long-term result after successful withdrawal therapy. Patients with risk factors according to our findings should be informed and monitored regularly, and combined drugs should be avoided. Furthermore, our data suggest that there is a need for research on individual psychological and behavioral risk factors for relapse after successful withdrawal therapy in drug-induced headache.

show abstract

Ergotamine- and Analgesic-Induced Headaches

Cited by 17 publications

References 0 publications

Behavioral and Pharmacologic Treatment of Transformed Migraine With Analgesic Overuse: Outcome at 3 Years

Behavioral and Pharmacologic Treatment of Transformed Migraine With Analgesic Overuse: Outcome at 3 Years

Longterm Prognosis of Analgesic Withdrawal in Patients with Drug‐Induced Headaches

Drug-Induced Headache: Long-Term Results of Stationary Versus Ambulatory Withdrawal Therapy

Contact Info

Product

Resources

About