2018
DOI: 10.1002/1873-3468.13123
|View full text |Cite
|
Sign up to set email alerts
|

Ergothioneine – a diet‐derived antioxidant with therapeutic potential

Abstract: Ergothioneine is a thiol/thione molecule synthesised only by some fungi and bacteria. Nonetheless, it is avidly taken up from the diet by humans and other animals through a transporter, OCTN1, and accumulates to high levels in certain tissues. Ergothioneine is not rapidly metabolised, or excreted in urine and is present in many, if not all, human tissues and body fluids. Ergothioneine has powerful antioxidant and cytoprotective properties in vitro and there is evidence that the body may concentrate it at sites… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

6
193
0
3

Year Published

2018
2018
2022
2022

Publication Types

Select...
6
1

Relationship

1
6

Authors

Journals

citations
Cited by 210 publications
(202 citation statements)
references
References 95 publications
(193 reference statements)
6
193
0
3
Order By: Relevance
“…This extension in mean and maximal lifespan with ET treatment would equate to years when translated to a human lifespan, but more importantly, the increased healthspan would lead to a significant reduction in morbidity and societal burden. It should also be noted that numerous animal and human studies have demonstrated that blood and tissue levels of ET are capable of reaching millimolar levels hence validating the feasibility of the doses tested in the nematodes .…”
Section: Discussionmentioning
confidence: 84%
“…This extension in mean and maximal lifespan with ET treatment would equate to years when translated to a human lifespan, but more importantly, the increased healthspan would lead to a significant reduction in morbidity and societal burden. It should also be noted that numerous animal and human studies have demonstrated that blood and tissue levels of ET are capable of reaching millimolar levels hence validating the feasibility of the doses tested in the nematodes .…”
Section: Discussionmentioning
confidence: 84%
“…The natural selection of such a transporter implies that ergothioneine is involved in the maintenance of health or the mitigation of disease, and it may even be a vitamin (Paul and Snyder, 2010). ERG has demonstrated effects in in vivo models of several neurodegenerative diseases (Link, 1995; Song et al, 2014; Yang et al, 2012), in ischaemia reperfusion injury (Bedirli et al, 2004; Sakrak et al, 2008a, 2008b), and in a variety of other diseases (Halliwell et al, 2018). Ergothioneine accumulates at sites of injury through the upregulation of SLC22A4/OCTN1 (Cheah et al, 2016; Tang et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…Because humans cannot produce ERG, they must obtain it through their diet. Although plants and animals also accumulate it to some degree, the main natural dietary source of ERG is basidiomycete mushrooms, where some species contain up to 7 mg of ERG per gram dry weight (Ey et al, 2007; Halliwell et al, 2018; Kalaras et al, 2017; Pfeiffer et al, 2011). Because of the beneficial effects and possible involvement of ERG in disease, ergothioneine may potentially prove its value in the global dietary supplement market, which was estimated at some $241.1 billion in 2019 (Wang et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…Keywords: Cobalt · Manganese · Ferrites · Carbon nanotubes · Graphene · Hybrid nanomaterials · Hydrogen peroxide · Electrocatalysis Hydrogen peroxide is a key metabolite intimately related to several metabolic pathways and is widely used in food, pharmaceutical, chemical and biochemical industries [1,2]. The study of the electroreduction of hydrogen peroxide has received considerable attention mainly due to the importance of the development of oxidases-based biosensors, non-enzymatic sensors and fuel cells.…”
Section: Introductionmentioning
confidence: 99%
“…Glassy carbon electrodes (GCE) modified with these hybrid nanomaterials dispersed in Nafion/isopropanol demonstrated a clear synergism on the catalytic reduction of reduction of hydrogen peroxide at pH 13.00. The intimate interaction between MFe 2 O 4 and carbon nanomaterials allowed a better electronic transfer and a facilitated regeneration of M 2 + at the carbon nanomaterials, reducing the charge transfer resistances for hydrogen peroxide reduction and increasing the sensitivities of the amperometric response.Hydrogen peroxide is a key metabolite intimately related to several metabolic pathways and is widely used in food, pharmaceutical, chemical and biochemical industries [1,2]. The study of the electroreduction of hydrogen peroxide has received considerable attention mainly due to the importance of the development of oxidases-based biosensors, non-enzymatic sensors and fuel cells.…”
mentioning
confidence: 99%