2024
DOI: 10.1002/jat.4728
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Ergothioneine Ameliorates Liver Fibrosis by Inhibiting Glycerophospholipids Metabolism and TGF‐β/Smads Signaling Pathway: Based on Metabonomics and Network Pharmacology

Yaping Mao,
Zhenghui Xie,
Xiangxia Zhang
et al.

Abstract: Ergothioneine (EGT) is a diet‐derived natural sulfur‐containing amino acid that exhibits strong anti‐oxidant and anti‐inflammation activities. Oxidative stress and chronic inflammatory injury are predominant pro‐fibrogenic factors. Therefore, EGT may have therapeutic potential against liver fibrosis; however, its underlying mechanism is incompletely understood. This study aimed at investigating the protective effects of EGT on liver fibrosis based on metabonomics and network pharmacology. A mouse model of live… Show more

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