Ergothioneine protects against neuronal injury induced by β-amyloid in mice

Yang, Nae-Cherng; Lin, Herng Ching; Wu, Jeng-Yue; Ou, Hsiu‐Chung; Chai, Yu-Chin; Tseng, Chin‐Yin; Liao, Jiunn‐Wang; Song, Tuzz-Ying

doi:10.1016/j.fct.2012.08.021

Cited by 93 publications

(76 citation statements)

References 60 publications

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“…. Previous reports suggest that ET is capable of alleviating Aβ‐induced toxicity by mitigating oxidative damage . However, supplementation of CL2006 nematodes with ET did not alter basal levels of protein carbonyls or protein‐bound HNE (Fig.…”

Section: Discussionmentioning

confidence: 69%

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Inhibition of amyloid‐induced toxicity by ergothioneine in a transgenic Caenorhabditis elegans model

Cheah

et al. 2019

FEBS Letters

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The abnormal accumulation of β‐amyloid peptide (Aβ) is recognized as a central component in the pathogenesis of Alzheimer disease. While many aspects of Aβ‐mediated neurotoxicity remain elusive, Aβ has been associated with numerous underlying pathologies, including oxidative and nitrosative stress, inflammation, metal ion imbalance, mitochondrial dysfunction, and even tau pathology. Ergothioneine (ET), a naturally occurring thiol/thione‐derivative of histidine, has demonstrated antioxidant and neuroprotective properties against various oxidative and neurotoxic stressors. This study investigates ET’s potential to counteract Aβ‐toxicity in transgenic Caenorhabditis elegans overexpressing a human Aβ peptide. The accumulation of Aβ in this model leads to paralysis and premature death. We show that ET dose‐dependently reduces Aβ‐oligomerization and extends the lifespan and healthspan of the nematodes.

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Section: Discussionmentioning

confidence: 69%

“…Yang et al . demonstrated that ET protected against neuronal injury caused by administration of a single dose of Aβ 1–40 into the hippocampus of mice, and increased scores in active avoidance and water maze tests. Song et al .…”

Section: Discussionmentioning

confidence: 96%

Inhibition of amyloid‐induced toxicity by ergothioneine in a transgenic Caenorhabditis elegans model

Cheah

et al. 2019

FEBS Letters

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“…It tends to accumulate in tissues over time and protects against tissue damage by decreasing lipid peroxidation levels via the catabolism of s-nitrosoglutathione 29. Yang et al 30 recently reported the protective effects of ergothioneine against the accumulation of amyloid-β protein in a mouse model. These findings suggest that the decrease in serum ergothioneine levels may be associated with the development of neurodegenerative disorders.…”

Section: Discussionmentioning

confidence: 99%

Identification of novel biomarkers for Parkinson's disease by metabolomic technologies

Hatano

Saiki

Okuzumi

et al. 2015

J Neurol Neurosurg Psychiatry

220

179

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“…The OCTN1 substrate antioxidant ERGO was reported to protect neurons from cytotoxicity induced by a variety of neurotoxins, including N-methyl-Daspartate, β-amyloid, and cisplatin. [28][29][30] It was demonstrated that systemically administered ERGO is taken up by neurons via OCTN1 in vivo, supporting such a protective role of this transporter. 16) Interestingly, the expression of the OCTN1 gene product is increased in inflammatory tissues of peripheral organs.…”

Section: Physiological Roles Of Organic Cation Transporters In Neuronsmentioning

confidence: 96%

Physiological Roles of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Neural Cells

Nakamichi

Kato

2017

Biological & Pharmaceutical Bulletin

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Dysfunction in neurotransmission mediated by neurotransmitters causes various neurological disorders.Therefore, receptors and reuptake transporters of neurotransmitters have been focused on as a therapeutic target in neurological disorders. These membrane proteins have high affinity for a specific neurotransmitter and are highly expressed on synaptic membranes. In contrast, xenobiotic transporters have relatively lower affinity for neurotransmitters but widely recognize various organic cations and/or anions and are also expressed in brain neurons. However, it has been largely unknown why such xenobiotic transporters are expressed in neurons that play a key role in signal transduction. We have therefore attempted to clarify the physiological roles of one such xenobiotic organic cation transporter (OCT) in neural cells with the aim of obtaining new insight into the treatment of neurological disorders. Carnitine/organic cation transporter OCTN1/SLC22A4 is functionally expressed in neurons and neural stem cells. In particular, OCTN1 is expressed at much higher levels compared with other OCTs in neural stem cells and positively regulates their differentiation into neurons. OCTN1 accepts the naturally occurring food-derived antioxidant ergothioneine (ERGO) as a good in vivo substrate. Because ERGO is highly distributed into the brain after oral ingestion, OCTN1 may contribute to the alleviation of oxidative stress and promotion of neuronal differentiation via the uptake of ERGO in the brain, perhaps abating symptoms of neurological disorders. In this review, we introduce current topics on the physiological roles of OCTs with a focus on OCTN1 in neural cells and discuss its possible application to the treatment of neurological disorders.

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Ergothioneine protects against neuronal injury induced by β-amyloid in mice

Cited by 93 publications

References 60 publications

Inhibition of amyloid‐induced toxicity by ergothioneine in a transgenic Caenorhabditis elegans model

Inhibition of amyloid‐induced toxicity by ergothioneine in a transgenic Caenorhabditis elegans model

Identification of novel biomarkers for Parkinson's disease by metabolomic technologies

Physiological Roles of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Neural Cells

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