Erhöhter Augeninnendruck für 7 Wochen induziert lokale Gefäßveränderungen im experimentellen Glaukommodell in vivo

Mann, Carolina; Anders, Fabian; Liu, Hanhan; Brockhaus, Katrin; Liu, Aiwei; Grus, Franz H.; Pfeiffer, Norbert; Thanos, Solon; Prokosch, Verena

doi:10.1055/s-0044-101617

Cited by 5 publications

(6 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have provided evidence that compared with healthy individuals, the blood flow in the eyes of glaucoma patients is significantly reduced, furthermore, the blood flow in the optic papilla region is reduced more obviously [ 62 , 63 , 64 ]. Furthermore, this was also demonstrated in our previous study in an in vivo glaucoma animal model, elevated IOP leads to shrinking of retinal vascular caliber [ 65 ], which limits the blood flow and oxygen supply in the retina and consequently promotes the production and accumulation of ROS [ 66 ]. Morphological and functional changes of the vascular play a central role in hemodynamic changes.…”

Section: The Anti-oxidative Properties Of H 2 S In Glaucomasupporting

confidence: 61%

Current Perspective of Hydrogen Sulfide as a Novel Gaseous Modulator of Oxidative Stress in Glaucoma

2021

Self Cite

View full text Add to dashboard Cite

Glaucoma is a group of diseases characterized by the progressive loss of retinal ganglion cells and their axons. Elevated intraocular pressure (IOP) is the main clinical manifestation of glaucoma. Despite being in the focus of the studies for decades, the characteristic and the exact pathology of neurodegeneration in glaucoma remains unclear. Oxidative stress is believed to be one of the main risk factors in neurodegeneration, especially its damage to the retinal ganglion cells. Hydrogen sulfide (H2S), the recently recognized gas signaling molecule, plays a pivotal role in the nervous system, vascular system, and immune system. It has also shown properties in regulating oxidative stress through different pathways in vivo. In this review, we summarize the distribution and the properties of H2S within the eye with an emphasis on its role in modulating oxidative stress in glaucoma.

show abstract

Section: The Anti-oxidative Properties Of H 2 S In Glaucomasupporting

confidence: 61%

Current Perspective of Hydrogen Sulfide as a Novel Gaseous Modulator of Oxidative Stress in Glaucoma

2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…The artery enters the eye through the optic nerve and travels through the center of the optic nerve to reach the retina. The CRA then divides into multiple smaller branches that supply blood to the inner retina, which includes the ganglion cells, inner plexiform layer, and inner nuclear layer [17,21]. The choroidal circulation is a network of blood vessels that lies between the retina and the sclera, the outermost layer of the eye.…”

Section: The Anatomy Of Blood Supply In the Retinamentioning

confidence: 99%

“…Retinal vascular dysfunction has been observed as a secondary manifestation both in individuals diagnosed with glaucoma and animal models employed to study the disease, suggesting that glaucoma may also serve as the instigator of retinal vascular abnormalities [16]. These secondary manifestations encompass various alterations, such as a notable reduction in retinal vascular diameter [17], decreased retinal vascular density [18], disturbances in retinal vascular molecules [19], impaired autoregulation of blood flow, dysfunction of retinal arterioles [16], and instances of retinal vein occlusion [17,20]. In this section, we aim to provide a comprehensive and in-depth discussion of the aforementioned alterations observed in both glaucoma patients and animal models used for studying the disease.…”

Section: Glaucoma Can Also Be the Instigator Of Retinal Vascular Abno...mentioning

confidence: 99%

“…Retinal vascular dysfunction has been reported secondary to glaucoma, indicative of a bidirectional relationship between glaucoma and retinal vascular pathology [16]. These secondary manifestations of glaucoma include a reduction in retinal vascular diameter [17], decreased retinal vascular density [18], alterations in retinal vascular molecules [19], impaired autoregulation, arteriolar dysfunction within the retina [16], and even occurrences of retinal vein occlusion [17,20]. However, the answer to the question of whether vascular abnormalities drive glaucoma progression or if glaucoma serves as the instigator of vascular abnormalities remains elusive.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Association between Vascular Abnormalities and Glaucoma—What Comes First?

Wang,

Liu

et al. 2023

IJMS

View full text Add to dashboard Cite

Glaucoma is a leading cause of irreversible blindness worldwide. While intraocular pressure (IOP) presents a major risk factor, the underlying pathophysiology still remains largely unclear. The correlation between vascular abnormalities and glaucoma has been deliberated for decades. Evidence for a role played by vascular factors in the pathogenesis of glaucomatous neurodegeneration has already been postulated. In addition, the fact that glaucoma causes both structural and functional changes to retinal blood vessels has been described. This review aims to investigate the published evidence concerning the relationship between vascular abnormalities and glaucoma, and to provide an overview of the “chicken or egg” dilemma in glaucoma. In this study, several biomarkers of glaucoma progression from a vascular perspective, including endothelin-1 (ET-1), nitric oxide, vascular endothelial growth factor (VEGF), and matrix metalloproteinases (MMPs), were identified and subsequently assessed for their potential as pharmacological intervention targets.

show abstract

“…MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions, or products referred to in the content. 2 hand, it has been observed that retinal vascular abnormalities are a secondary manifestation of glaucomatous neurodegeneration, suggesting that glaucoma itself may also induce retinal vascular abnormalities [ 8,9]. Studies demonstrate that impaired RGCs require reduced blood supply, causing retinal arteriolar constriction [7].…”

Section: Introductionmentioning

confidence: 99%

Is Primary Open-Angle Glaucoma a Vascular Disease? – Assessment of the Relationship of Retinal Arteriolar Morphology and Glaucoma Severity Using Adaptive Optics

Szewczuk,

Wawrzyniak,

Szaflik

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Retinal vascular abnormalities may be associated with glaucomatous damage. Adaptive optics (AO) is a new technology that enables analysis of retinal vasculature at the cellular level in vivo. The purpose of this study is to evaluate retinal arteriolar parameters using the adaptive optics fundus camera (AO -FC) rtx1 in patients with primary open-angle glaucoma (POAG) at different stages and to investigate the relationship between these parameters and changes in optical coherence tomography (OCT) and perimetry. We wanted to assess whether vascular changes could be a cause or effect of glaucomatous damage. Methods: Parameters of retinal supratemporal and infratemporal arterioles (wall thickness (WT), lumen diameter (LD), total diameter (TD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall (WCSA)) were analysed with the rtx1 in 111 POAG eyes, divided into three groups according to the severity of disease and 70 healthy eyes in correlation of structural defects in retinal nerve fibre layer and visual fields defects. Results: Compared with the control group, the POAG groups showed significantly smaller TD and LD values (p<0,05) and significantly higher WLR and WT values (p<0,05) for supratemporal and infratemporal arterioles. Rtx1 parameters significantly correlated with OCT parameters (retinal nerve fibre layer, ganglion cell complex and rim area) and visual field parameters (mean deviation and pattern standard deviation) (p<0.05). Conclusion: The results suggest that vascular dysfunction may be involved in POAG pathogenesis and neurodegenerative damage, even at the very early stage of glaucoma, without visual field defects.

show abstract

Erhöhter Augeninnendruck für 7 Wochen induziert lokale Gefäßveränderungen im experimentellen Glaukommodell in vivo

Cited by 5 publications

References 28 publications

Current Perspective of Hydrogen Sulfide as a Novel Gaseous Modulator of Oxidative Stress in Glaucoma

Current Perspective of Hydrogen Sulfide as a Novel Gaseous Modulator of Oxidative Stress in Glaucoma

The Association between Vascular Abnormalities and Glaucoma—What Comes First?

Is Primary Open-Angle Glaucoma a Vascular Disease? – Assessment of the Relationship of Retinal Arteriolar Morphology and Glaucoma Severity Using Adaptive Optics

Contact Info

Product

Resources

About