Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity

Hu, Qingwen; Zhang, Donna D.; Wang, Limei; Lou, Hongxiang; Ren, Dongmei

doi:10.1016/j.fct.2012.03.059

Cited by 52 publications

(20 citation statements)

References 29 publications

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“…Etyol is a flavonoid isolated from the Chinese herb Dracocephalum rupestre that has antiinflammatory [13] and antioxidant properties [14,15].…”

Section: Discussionmentioning

confidence: 99%

“…Eriodictyol (Etyol) is a flavonoid, "flavanone", (3′,4′,5,7-tetrahydroxyflavanone) isolated from the Chinese herb (Dracocephalum rupestre) and citrus fruits. There is evidence for its antiinflammatory, anti-allergenic, antimicrobial, anti-cancer [13] and antioxidant properties [14,15]. Eriodictyol reduced nitric oxide (NO) and pro-inflammatory cytokines in LPSstimulated Raw 264.7 cells and suppressed the phagocytic activity of activated macrophages.…”

Section: Introductionmentioning

confidence: 99%

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Neuroinflammatory response to experimental stroke is inhibited by eriodictyol

Ferreira

Fernandes

Lima

et al. 2016

Behavioural Brain Research

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“…Etyol is a flavonoid isolated from the Chinese herb Dracocephalum rupestre that has antiinflammatory [13] and antioxidant properties [14,15].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuroinflammatory response to experimental stroke is inhibited by eriodictyol

Ferreira

Fernandes

Lima

et al. 2016

Behavioural Brain Research

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“…Several herbal compounds including nordihydroguaiaretic acid, eriodictyol‐7‐O‐glucoside, and thymol ameliorated cisplatin‐induced renal injury, in vitro and in vivo (Hosseinimehr et al, ; Hu, Zhang, Wang, Lou, & Ren, ; Mundhe et al, ). Resveratrol, genistein, and epigallocatechin‐3‐gallate attenuated apoptosis of haematopoietic cells via reducing DNA damage (Alotaibi, Bhatnagar, Najafzadeh, Gupta, & Anderson, ; Olas & Wachowicz, ; Sonaa, Usha, & Ja In, ).…”

Section: Herbal Compounds With the Potential To Synergize With Antitumentioning

confidence: 99%

Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

Lin

Hsu

Tsai

et al. 2019

British J Pharmacology

289

175

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Traditional chemotherapy is being considered due to hindrances caused by systemic toxicity. Currently, the administration of multiple chemotherapeutic drugs with different biochemical/molecular targets, known as combination chemotherapy, has attained numerous benefits like efficacy enhancement and amelioration of adverse effects that has been broadly applied to various cancer types. Additionally, seeking natural‐based alternatives with less toxicity has become more important. Experimental evidence suggests that herbal extracts such as Solanum nigrum and Claviceps purpurea and isolated herbal compounds (e.g., curcumin, resveratrol, and matairesinol) combined with antitumoral drugs have the potential to attenuate resistance against cancer therapy and to exert chemoprotective actions. Plant products are not free of risks: Herb adverse effects, including herb–drug interactions, should be carefully considered. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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“…Eriodictyol is a strong flavonoid extracted from Eriodictyon californicium and is also called as California yerba santa [4]. It exhibits well-known antioxidant, anti-inflammatory, antineoplastic, antimicrobial, and antinociception activities ( Fig.1) [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Computational Studies on Different Types of Apoptotic Proteins Docked With a Dietary Flavonoid Eriodictyol in Colon Cancer

Palani

Natesan

Vaiyapuri

2016

Asian J Pharm Clin Res

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Objective: In this study, to evaluate the computational studies of eriodictyol docked with apoptotic proteins.Methods: AutoDock Vina and Molecular Graphics Laboratory tools were used to determine the interaction between proteins and eriodictyol. Discovery studio visualizer and PyMOL were used to determine the interaction of amino acid residues between apoptotic proteins and eriodictyol. Results:The obtained results revealed more binding affinities of p53, caspase 8, B-cell lymphoma (Bcl)-2, Bcl-2 -associated X protein (BAX), and adenomatous polyposis coli (APC) of −10.6, −10.9, −9.0, −9.5, and 7.2 kcal/mol, respectively. Interaction of hydrophobic polar contacts of amino acid residues of p53 (CYS-277 and ALA-276), caspase 8 [THR-467, THR-337 (2), and GLU-396 (2)], Bcl-2 [ARG-103 (3), ALA-104 (2), and PHE-105, TYR-101], BAX [GLY-108, TRY-107, ASN-106, and GLN-155 (2)], and APC [GLU-40 (2) and LEU-37 (2)] were notified between macromolecules and small molecules. The calculation of root-mean-square deviation of proteins and eriodictyol showed the lower binding energies to be 11.6, 12.5, 15.9, 19.6, and 15.8 and the upper binding energies to be 12.4, 15.3, 16.9, 20.7, and 18, respectively. The homology of binding energies was determined below 2Å which is computationally less expensive and easily determined the hydrophobic polar contacts. Conclusions:The homology of binding energies was determined below 2Å which is computationally less expensive and easily determined the hydrophobic polar contacts. The results were proved that the eriodictyol highly interacted with apoptotic proteins. It might be a strong anti-inflammatory activity of colon cancer. In future, computational molecular docking studies should aid further in vitro and in vivo studies.

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Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity

Cited by 52 publications

References 29 publications

Neuroinflammatory response to experimental stroke is inhibited by eriodictyol

Neuroinflammatory response to experimental stroke is inhibited by eriodictyol

Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

Computational Studies on Different Types of Apoptotic Proteins Docked With a Dietary Flavonoid Eriodictyol in Colon Cancer

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