Eriodictyol attenuates doxorubicin-induced nephropathy by activating the AMPK/Nrf2 signalling pathway

Badi, Rehab Mustafa; Khaleel, Eman Farok; Satti, Huda Hammed; Monir, Rehan

doi:10.1016/j.jtcme.2023.11.003

Cited by 4 publications

(1 citation statement)

References 60 publications

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“…QCT also shows promise in the treatment of neurological disorders such as Parkinson’s disease (PD) ( Jiang et al, 2023 ). Eriodictyol , another flavonoid, was found to upregulate Nrf2/HO-1 and reduce ROS levels in a renal injury model, providing protection against CP-induced AKI ( Badi et al, 2024 ). Furthermore, Eriodictyol has been shown to inhibit ferroptosis and improve cognitive deficits in APP/PS1 mice through activation of the Nrf2/HO-1 pathway ( Li et al, 2022 ; Zhang et al, 2022 ).…”

Section: Small Molecule Ferroptosis Inhibitorsmentioning

confidence: 99%

Ferroptosis inhibitors: past, present and future

Zhang,

Luo,

Xiang

et al. 2024

Front. Pharmacol.

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Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed the mechanisms of its formation and continue to explore effective inhibitors of ferroptosis in disease. Recent studies have shown a correlation between ferroptosis and the pathological mechanisms of neurodegenerative diseases, as well as diseases involving tissue or organ damage. Acting on ferroptosis-related targets may provide new strategies for the treatment of ferroptosis-mediated diseases. This article specifically describes the metabolic pathways of ferroptosis and summarizes the reported mechanisms of action of natural and synthetic small molecule inhibitors of ferroptosis and their efficacy in disease. The paper also describes ferroptosis treatments such as gene therapy, cell therapy, and nanotechnology, and summarises the challenges encountered in the clinical translation of ferroptosis inhibitors. Finally, the relationship between ferroptosis and other modes of cell death is discussed, hopefully paving the way for future drug design and discovery.

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Section: Small Molecule Ferroptosis Inhibitorsmentioning

confidence: 99%

Ferroptosis inhibitors: past, present and future

Zhang,

Luo,

Xiang

et al. 2024

Front. Pharmacol.

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Molecular signaling pathways in doxorubicin-induced nephrotoxicity and potential therapeutic agents

Lu,

Wei,

Gao

et al. 2025

International Immunopharmacology

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Elucidation of Anti-Obesity Mechanisms of Phenolics in Artemisiae argyi Folium (Aiye) by Integrating LC-MS, Network Pharmacology, and Molecular Docking

Liu,

Luo,

2024

Life

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The global prevalence of obesity is a pressing health issue, increasing the medical burden and posing significant health risks to humans. The side effects and complications associated with conventional medication and surgery have spurred the search for anti-obesity drugs from plant resources. Previous studies have suggested that Artemisiae argyi Folium (Aiye) water extracts could inhibit pancreatic lipase activities, control body weight increase, and improve the plasma lipids profile. However, the exact components and mechanisms were not precisely understood. Therefore, this research aims to identify the chemical profile of Aiye and provide a comprehensive prediction of its anti-obesity mechanisms. The water extract of Aiye was subjected to LC-MS analysis, which identified 30 phenolics. The anti-obesity mechanisms of these phenolics were then predicted, employing network pharmacology and molecular docking. Among the 30 phenolics, 21 passed the drug-likeness screening and exhibited 486 anti-obesity targets. The enrichment analysis revealed that these phenolics may combat obesity through PI3K-Akt signaling and MAPK, prolactin, and cAMP signaling pathways. Eight phenolics and seven central targets were selected for molecular docking, and 45 out of 56 docking had a binding affinity of less than −5 kcal/mol. This research has indicated the potential therapy targets and signaling pathways of Aiye in combating obesity.

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Eriodictyol attenuates doxorubicin-induced nephropathy by activating the AMPK/Nrf2 signalling pathway

Cited by 4 publications

References 60 publications

Ferroptosis inhibitors: past, present and future

Ferroptosis inhibitors: past, present and future

Molecular signaling pathways in doxorubicin-induced nephrotoxicity and potential therapeutic agents

Elucidation of Anti-Obesity Mechanisms of Phenolics in Artemisiae argyi Folium (Aiye) by Integrating LC-MS, Network Pharmacology, and Molecular Docking

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