Eriodictyol induces apoptosis via regulating phosphorylation of JNK, ERK, and FAK/AKT in pancreatic cancer cells

Abstract

Although it has been intensively studied over the past few decades, pancreatic cancer remains one of the most lethal cancers. Eriodictyol, a plant-derived flavonoid mainly found in citrus fruits, exerts diverse biological effects, including antioxidant, anti-cancer, and anti-inflammatory properties. In this study, we investigated the anticancer properties of eriodictyol and its mechanisms of action in pancreatic cancer cells. In both SNU213 and Panc-1 cells, eriodictyol decreased viability, induced apoptosis, and decreased clonogenicity. In addition, eriodictyol treatment increased the phosphorylation level of JNK and decreased the phosphorylation levels of ERK, FAK, and AKT. These observations provide insight into the molecular mechanisms of eriodictyol-induced apoptosis in pancreatic cancer cell lines, and could contribute to the development of candidate compounds for treating pancreatic cancer.

Natural Blockers of PD-1/PD-L1 Interaction for the Immunotherapy of Triple-Negative Breast Cancer-Brain Metastasis

“…Toxicodendron vernicifluum (TV) or Rhus verniciflua Stokes is another traditional herbal medicine native to China, India, Japan, and Korea and is a source of flavonoids and polyphenols such as eriodictyol (ERI), fisetin (FIS) and QUE [ 37 ]. ERI and FIS share a similar backbone structure to those of API, KMF, and QUE ( Figure 1 d) and have also shown some anticancer potential in several cancer models such as breast, colon, and pancreas cancers [ 38 , 39 , 40 , 41 , 42 ]. In 2020, Li et al showed that the extract of TV (TVE) inhibited the interaction of PD-1/PD-L1 in a dose-dependent manner (IC 50 ~26 µM in a competitive ELISA— Table 1 ).…”

Phosphoproteome Reveals Extracellular Regulated Protein Kinase Phosphorylation Mediated by Mitogen-Activated Protein Kinase Kinase-Regulating Granulosa Cell Apoptosis in Broody Geese

“…ERK is affected by various epigenetic modifications, including DNA methylation and histone modifications [13,14], and these modifications can affect its expression. For example, phosphorylation of Erkl/2 has a protective effect on the survival of rat axons and neurons [15,16], and conversely, phosphorylation of ERK and FAK/AKT can induce apoptosis [17]. Thus, epigenetic modifications of ERK can have both pro-and anti-apoptotic effects depending on the specific situation [18].…”