2020
DOI: 10.3389/fphar.2020.00114
|View full text |Cite
|
Sign up to set email alerts
|

Eriodictyol Inhibits Proliferation, Metastasis and Induces Apoptosis of Glioma Cells via PI3K/Akt/NF-κB Signaling Pathway

Abstract: Glioma is the most common type of malignant brain tumor. Due to its highly aggressive and metastatic features, glioma is associated with poor prognosis and a lack of effective treatments. Eriodictyol, a natural flavonoid compound, has been reported to possess antiinflammatory and antioxidant effects. However, the anti-tumor effects of eriodictyol and the underlying mechanisms have rarely been reported. In this study, we found that eriodictyol has anti-tumor activity in lung, colon, breast, pancreas, and liver … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
49
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 77 publications
(51 citation statements)
references
References 32 publications
2
49
0
Order By: Relevance
“…To confirm whether circ‐PRMT5 exerts its effects in breast cancer via the miR‐509‐3p/TCF7L2 axis and the PI3K/AKT pathway, we performed the subsequent rescue assays. 740 Y‐P, a well‐known activator of the PI3K/AKT pathway, was used at a concentration of 20 μg/mL 20,21 . As shown in Figure 6A,B, breast cancer cell viability and proliferation capacity were inhibited by down‐regulated circ‐PRMT5 but restored after overexpressing pcDNA3.1/TCF7L2.…”
Section: Resultsmentioning
confidence: 99%
“…To confirm whether circ‐PRMT5 exerts its effects in breast cancer via the miR‐509‐3p/TCF7L2 axis and the PI3K/AKT pathway, we performed the subsequent rescue assays. 740 Y‐P, a well‐known activator of the PI3K/AKT pathway, was used at a concentration of 20 μg/mL 20,21 . As shown in Figure 6A,B, breast cancer cell viability and proliferation capacity were inhibited by down‐regulated circ‐PRMT5 but restored after overexpressing pcDNA3.1/TCF7L2.…”
Section: Resultsmentioning
confidence: 99%
“…After 12 hours, various concentrations (0, 25, 50, 100 mmol/L) of eriodyctiol were added to each well, and cells were incubated for an additional 48 hours. Detailed procedures were performed as described in reference 22 …”
Section: Methodsmentioning
confidence: 99%
“…Eriodictyol concentration-dependently inhibited tumor growth and metastasis via the downregulation of the PI3K/Akt/NF-κB signaling pathway in U87MG and CHG-5 glioma cells [ 90 ].…”
Section: Targeting Metastatic Cancermentioning
confidence: 99%