Eritrodermia: estudo clínico-laboratorial e histopatológico de 170 casos

Abstract

Resumo: FUNDAMENTOS -A dermatite esfoliativa/eritrodermia é síndrome rara e grave, de etiologia freqüentemente desconhecida. A hospitalização é necessária para avaliação inicial e tratamento. OBJETIVO

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“…A survey of erythroderma cases conducted in the Portugal identified an annual incidence of 9.4 cases/year [1], and another Tunisian series reported a hospital incidence of 6.3 cases/year [5], an increased incidence as we found, has never been noted in the literature, this could be explained by the delay of the consultation of patients. Erythroderma usually occurs in the fifth decade with a male predominance in the majority of reported studies [6][7][8][9][10][11][12][13][14].Our series is in accordance with the literature, concerning the age of patients, but with a female predominance. Typically, the onset of erythroderma is gradual and insidious [5,[9][10][11], except in the drug-induced cases, where it tends to be sudden [5,12] In our series we identified similar results, given that drug-induced cases were associated with a shorter duration of erythroderma before admission.…”

“…We also noted that fever was more frequently associated with drug reactions, an association previously identified in three other recent series [1,8,9]. We found a higher percentage of lymphadenopathy and hepatic/splenic enlargement in comparison with previous series [8][9][10][11][12][13][14].…”

“…In previous publications, lymphadenopathy has been associated with cutaneous T-cell lymphomas, drug reactions and psoriasis [10] Hepatic or splenic enlargement have been reported in association with erythroderma caused by drug consumption [2]. In our study however, we only found significant associations between both lymphadenopathy and hepatic/splenic enlargement, and the group of patients with cutaneous T-cell lymphomas.…”

“…The final diagnosis is a result of the evaluation of the clinical, biochemical, histological findings and the evolution of the erythroderma in each individual patient. Like many other series [4,[8][9][10][11][12][13][14], the majority of clinical features were non-specific. As in other studies [11,12,14], pruritus was the most common complaint of our patients and could not be traced to any specific cause of erythroderma.…”

Psoríase Eritrodérmica: relato de caso e revisão bibliográfica

“…Em fase avançada, acompanha-se de destruição dos anexos, com alopecia generalizada e distrofia ungueal. 1,3 Apesar de a síndrome ser mais comum em homens e idosos, 4 a pandemia pelo HIV levou à sua maior incidência em grupos mais jovens. 3 Entre as possíveis etiologias, devem ser cogitadas não apenas doenças dermatológicas primárias, mas também, reação alérgica a certas drogas, doenças sistêmicas, além de neoplasias.…”