Eritropoyetina preoperatoria como estrategia de ahorro de sangre en cirugía ortopédica mayor en pacientes de edad avanzada

Bisbe, E.; Castillo, Jorge; Nomen, Nuria; Mestre, Carlos; González, Raúl

doi:10.1016/s0025-7753(04)74536-4

Cited by 9 publications

(2 citation statements)

References 7 publications

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“…Mild anemia in the elderly is often considered physiologic although it seems to be associated with poor health status and a decline in physical performance, 10 increased morbidity/mortality and resource utilization in surgery, 12,13 and even, higher mortality in nursing home and community residents 8,11 . In addition to a demonstrated inverse relationship between postoperative morbid‐mortality and Hb level, 16 there is a relationship between preoperative anemia and perioperative blood transfusion 5,6 and between correction of preoperative anemia and reduction in blood transfusion requirements in patients undergoing MOS 19,20,30–33 . Moreover, a European study including almost 4000 MOS patients showed an inverse relationship between preoperative Hb values and the probability of receiving ABT (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…Within the context of our study, one‐third of the patients were anemic and the anemia could be appropriately corrected before surgery by means of a safe and low‐cost pharmacological treatment (iron, folic acid, vitamin B 12 ). Those with ACD (30.7%) and mixed‐cause anemia (13.8%) would probably benefit from the combined administration of vitamin B 12 and/or intravenous iron plus subcutaneous EPO 30,32,33 . Finally, though there is obviously no specific treatment for AIC patients, some may respond to the administration of EPO.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of preoperative anemia and hematinic deficiencies in patients scheduled for elective major orthopedic surgery

Bisbe

Castillo

Sáez

et al. 2008

Transfus Alt Transfus Med

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SUMMARY Preoperative anemia is an independent risk factor for allogeneic blood transfusion in patients undergoing major orthopedic surgery (MOS) whereas hematinic deficiency can delay the recovery from postoperative anemia. Both conditions can, however, be corrected before elective procedures are undertaken. We therefore evaluated the prevalence of anemia and hematinic deficiencies in MOS patients. Demographic and laboratory data were gathered from all MOS patients from a single institution between January 2001 and December 2002. A total of 715 patients (483 women/232 men) entered the study. According to WHO criteria, the prevalence of anemia was 10.5% and increased with age, without gender‐related differences. Preoperative hemoglobin was < 13 g/dL in 19.4% of patients, and the prevalence of hematinic deficiencies was 33% for iron, 12.3% for vitamin B12 and 3% for folate. In anemic patients, there were 30.8% with hematinic deficiency anemia (20% with iron‐deficiency anemia), 30.8% with anemia of chronic disease and 38.4% with anemia of mixed or indeterminate cause. The prevalence of anemia, as well as of hematinic deficiencies, is high in MOS patients. Therefore, whenever possible, patients undergoing MOS should be assessed early enough to allow for proper investigation and treatment prior to the scheduled procedure.

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