ERK signaling is required for eye-specific retino-geniculate segregation

Naska, Sibel; Cenni, Maria Cristina; Menna, Elisabetta; Maffei, Lamberto

doi:10.1242/dev.01212

Cited by 12 publications

(10 citation statements)

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“…This is the first report describing a regulation of MAPKs phosphorylation in the rat superior colliculus during development. A similar developmental regulation of ERK phosphorylation has been reported for the other main visual nucleus, the dLGN (Naska et al, 2004). The temporal correlation with the critical period for plasticity and in vivo blocking experiments, clearly demonstrated the involvement of the ERK pathway in the formation of eye‐specific domains at geniculate level (Naska et al, 2004).…”

Section: Methodssupporting

confidence: 82%

“…A similar developmental regulation of ERK phosphorylation has been reported for the other main visual nucleus, the dLGN (Naska et al, 2004). The temporal correlation with the critical period for plasticity and in vivo blocking experiments, clearly demonstrated the involvement of the ERK pathway in the formation of eye‐specific domains at geniculate level (Naska et al, 2004). Therefore, as the regulation of ERK1/2 and p38 MAPK phosphorylation in the superior colliculus detected in the present study correlates with the critical period for segregation of retino‐collicular projections (Land and Lund, 1979; Fawcett et al, 1984; Godement et al, 1984), it is likely that these pathways play an important role in plastic processes also at collicular level.…”

Section: Methodssupporting

confidence: 82%

“…More recently, it has been shown that ERK1/2 and p38 MAPK play a fundamental role also in synaptic plasticity processes in the hippocampus and in the visual system (Sweatt, 2004; Thomas and Huganir, 2004). Here, the ERK pathway is required for structural and functional plasticity during the development of the visual retino‐thalamo‐cortical pathway and p38 MAPK activation has been linked to long‐term depression at cortical level (Di Cristo et al, 2001; Naska et al, 2004; Xiong et al, 2006). Notwithstanding this information, very little is known on the role played by ERK1/2 in other visual structures and almost no information is available on p38 MAPK .…”

Section: Methodsmentioning

confidence: 99%

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The activation of ERK1/2 and p38 mitogen‐activated protein kinases is dynamically regulated in the developing rat visual system

Oliveira

Rigon

Leal

et al. 2008

Intl J of Devlp Neuroscience

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Mitogen-activated protein kinases (MAPKs) are serine/threonine kinases that play an instrumental role in signal transduction from the cell surface to the nucleus. These enzymes are major intracellular mediators of developmental events and recently have been shown to control also synaptic plasticity processes [Sweatt, J.D., 2004. Mitogen-activated protein kinases in synaptic plasticity and memory. Curr. Opin. Neurobiol. 14, 311-317; Thomas, G.M., Huganir, R.L., 2004. MAPK cascade signalling and synaptic plasticity. Nat. Rev. Neurosci. 5, 173-183]. Mammalian members of this family are extracellular signal-regulated kinases 1/2 (ERK 1/2), c-Jun amino-terminal kinases or stress-activated protein kinases (JNK/SAPKs) and p38 kinases (p38(MAPK)). At the level of the visual system, it has been demonstrated that the ERK pathway regulates developmental plastic processes at both retino-thalamic and thalamo-cortical level and that p38(MAPK) controls a peculiar form of long-term depression in the visual cortex [Di Cristo, G., Berardi, N., Cancedda, L., Pizzorusso, T., Putignano, E., Ratto, G.M., Maffei, L., 2001. Requirement of ERK activation for visual cortical plasticity. Science 292, 2337-2340; Naska, S., Cenni, M.C., Menna, E., Maffei, L., 2004. ERK signaling is required for eye-specific retino-geniculate segregation. Development 131, 3559-3570; Xiong, W., Kojic, L.Z., Zhang, L., Prasad, S.S., Douglas, R., Wang, Y., Cynader, M.S., 2006. Anisomycin activates p38 MAP kinase to induce LTD in mouse primary visual cortex. Brain Res. 1085, 68-76]. Here, as a first approach to gain more insight on the role of two MAPKs - ERK1/2 and p38(MAPK) - in visual system maturation, we characterized by western blot the regulation of their phosphorylation/activation in rat retina, superior colliculus and visual cortex, during postnatal development from birth to adult age. Our main results show that: (i) in the retina p38(MAPK) activation peaks at P4, and then, from P15 to P45, both ERK1/2 and p38(MAPK) phosphorylation increases; (ii) in the superior colliculus phosphorylation of both MAPKs increases between P4 and P15; (iii) in the visual cortex ERK1/2 phosphorylation increases from P15 to P45, while phosphorylation of p38(MAPK) increases starting from P4. The present data demonstrate a distinct regulation of the activation of ERK1/2 and p38(MAPK) in the three visual areas analyzed which occurs in temporal correlation with critical events for visual system maturation. These results suggest an important role for ERK1/2 and p38(MAPK) in the postnatal development of the rat visual system.

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Section: Methodssupporting

confidence: 82%

Section: Methodssupporting

confidence: 82%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The activation of ERK1/2 and p38 mitogen‐activated protein kinases is dynamically regulated in the developing rat visual system

Oliveira

Rigon

Leal

et al. 2008

Intl J of Devlp Neuroscience

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“…During perinatal life retinal axons from the two eyes share common terminal space in the dorsal lateral geniculate nucleus (LGN) but then segregate to form well-defined eye-specific territories (Godement et al 1984;Jaubert-Miazza et al 2005;Jeffery 1984;Linden et al 1981;Naska et al 2004;Shatz 1983). Although the anatomical rearrangement of retinogeniculate projections has been well documented, the functional changes that accompany this remodeling have not been fully realized.…”

Section: Introductionmentioning

confidence: 99%

“…Developing retinogeniculate projections were visualized by labeling axons and their terminal fields with the anterograde tracer cholera toxin subunit ␤ (CTB) (Angelucci et al 1996;Jaubert-Miazza et al 2005;Naska et al 2004;Torborg and Feller 2004). To study synaptic responses we used an in vitro isolated brain stem preparation in which large segments of each optic nerve are spared and the intrinsic circuitry of the LGN is left intact (Z iburkus et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Loss of Binocular Responses and Reduced Retinal Convergence During the Period of Retinogeniculate Axon Segregation

Žiburkus

Guido²

2006

Journal of Neurophysiology

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Z iburkus, Joku bas and William Guido. Loss of binocular responses and reduced retinal convergence during the period of retinogeniculate axon segregation. J Neurophysiol 96: 2775-2784, 2006. First published August 16, 2006 doi:10.1152/jn.01321.2004. In the developing mammalian visual system, axon terminals from the two eyes overlap in the dorsal lateral geniculate nucleus (LGN) but then undergo a period of refinement and segregate to form distinct eye-specific domains. We report on the changes in synaptic transmission that occur in rodent LGN during the period of retinogeniculate axon segregation by using anterograde labeling techniques in conjunction with an in vitro preparation where large segments of each optic nerve are preserved. Anterograde labeling of retinal projections in early postnatal day (P) rats with cholera toxin ␤ subunit indicated an age-related recession in uncrossed retinal projections. Between P2 and P5 uncrossed projections occupied as much as 50% of the LGN and overlapped substantially with crossed projections. Between the first and second postnatal week uncrossed projections receded, so by P14 they assumed an adultlike profile occupying 15-20% of LGN and showed little or no overlap with crossed projections. The postsynaptic responses of LGN cells evoked by the separate stimulation of each optic nerve indicated that before P14, many relay cells were binocularly innervated and received at least four to six inputs from each eye. However, these features of retinogeniculate connectivity were transient and their attrition occurred in concert with a retraction of retinal arbors into nonoverlapping, eye-specific regions. By P18 cells were monocularly innervated and received input from one to three retinal ganglion cells. These results provide a better understanding of the underlying changes in synaptic circuitry that occur during the anatomical segregation of retinal inputs into eye-specific territories.

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Retinorecipient areas in the diurnal murine rodent Arvicanthis niloticus: A disproportionally large superior colliculus

Gaillard

Karten

Sauvé

2013

J of Comparative Neurology

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The Nile grass rat (Arvicanthis niloticus) has a high proportion of cone photoreceptors (∼30-40%) compared with that in the common laboratory mouse and rat (∼1-3%) and may prove a preferable murine model with which to study cone-driven information processing in retina and primary visual centers. However, other than regions involved in circadian control, little is known about the retinorecipient structures in this rodent. We undertook a detailed analysis of the retinal projections as revealed after intravitreal injection of the anterograde tracer cholera toxin subunit B. Retinal efferents were evaluated in 45 subcortical structures. Contralateral projections were always dominant. Major contralateral inputs consisted of the suprachiasmatic nucleus, dorsolateral geniculate nucleus (dLGN), intergeniculate leaflet, ventral geniculate nucleus (magnocellular part), lateroposterior thalamic nucleus, all six pretectal nuclei, superficial layers of the superior colliculus (SC), and the main nuclei of the accessory optic system. Terminals from the contralateral eye were also localized in an unnamed field rostromedial to the dLGN as well as in the subgeniculate thalamic nucleus. Ipsilateral inputs were found mainly in the suprachiasmatic nucleus, dLGN, intergeniculate leaflet, internal sector of the magnocellular part of the ventral geniculate nucleus, olivary pretectal nucleus, and SC optic layer. Retinal afferents were not detected in the basal forebrain or the dorsal raphe nucleus. Morphometric measurements revealed that the superficial layers of the SC are disproportionately enlarged relative to other retinorecipient regions and brain size compared with rats and mice. We suggest that this reflects the selective projection of cone-driven retinal ganglion cells to the SC.

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ERK signaling is required for eye-specific retino-geniculate segregation

Cited by 12 publications

References 63 publications

The activation of ERK1/2 and p38 mitogen‐activated protein kinases is dynamically regulated in the developing rat visual system

The activation of ERK1/2 and p38 mitogen‐activated protein kinases is dynamically regulated in the developing rat visual system

Loss of Binocular Responses and Reduced Retinal Convergence During the Period of Retinogeniculate Axon Segregation

Retinorecipient areas in the diurnal murine rodent Arvicanthis niloticus: A disproportionally large superior colliculus

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