Erken ve Geç Laktasyon Periyodunun Keçilerde Plazma Oksidan/Antioksidan Dengesi Üzerindeki Etkileri

Karapehlivan, Mahmut; Kaya, İnan; Sağ, A.; Akın, Selçuk; Özcan, Ayla

doi:10.9775/kvfd.2012.8315

Cited by 4 publications

(5 citation statements)

References 36 publications

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“…Both reactive oxygen species and antioxidants have major physiological roles in all reproductive processes. This is similar to Karapehlivan et al (2012) that antioxidant potential reduced and oxidative stress increased in early lactation goats. And the depletion of critical antioxidant defense components in tissues may predispose to metabolic changes which originated from oxidative stress.…”

Section: Discussionsupporting

confidence: 85%

Metabolic and oxidative status of West African dwarf does at different reproductive stages in southwest Nigeria

2019

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Background: A study was conducted to investigate changes in oxidative stress indicators of West African dwarf (WAD) goats at different reproductive stages. There are a total of 35 dry does, 30 gravid does at first trimester (40-45 days post-mating), 33 gravid does at second trimester (85-90 days post-mating), 31 gravid does at third trimester (135-140 days post-mating), and 40 postpartum does (30-35 days postpartum). Fastened blood samples were collected from all tagged animals and serum obtained. Serum was assayed for lipid peroxidation, total antioxidant activity, glutathione peroxidase, catalase and superoxide dismutase, serum biochemical, glucose, total protein, albumin, cholesterol, triglyceride, high-density lipoprotein, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, urea, and creatinine using standard procedures. Results: Result revealed that intense metabolic changes were associated with late prepartum and postpartum does as pronounced in oxidative and biochemical indicators of WAD does. Significant differences were found in serum biochemical indices across the different physiological stages of the doe except for triglyceride and low-density lipoprotein. Antioxidant defense is higher at early and mid-gestation and dry does, through low lipid peroxidation and high antioxidant activity as compared to late gestation and lactation does. Conclusion: The observed result shows that the WAD does display oxidative stress during late gestation and lactation owing to intense metabolism. Antioxidant fortification should be employed especially during late gestation and lactation to counteract the oxidative stress in WAD goats.

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Section: Discussionsupporting

confidence: 85%

Metabolic and oxidative status of West African dwarf does at different reproductive stages in southwest Nigeria

2019

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“…Studies in Red Syrian goats report a significant decrease in glutathione peroxidase (GPX) activity and albumin concentration during the peripartum, suggesting that animals experienced moderate oxidative stress during this period [9]. Changes in total oxidative and antioxidant status were observed in local goats from early lactation to late lactation period and it was supposed to be associated to a different lipomobilization occurring in adipose tissue along the lactation period [10]. An influence of parity on the occurrence of peripartum redox imbalance was also observed when the metabolic and antioxidative status of Saanen goats of different parity were compared [11].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Status of Goats with Different CSN1S1 Genotypes Fed ad Libitum with Fresh and Dry Forages

et al. 2020

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Forty late-lactation Girgentana goats were used to study the effect of diets fed ad libitum and αS1-casein (CSN1S1) genotype on redox balance. The goats genotyped at CSN1S1 locus (A/A, A/F) were subjected to four feeding treatments different for percentage inclusion of dry and fresh forage: DAF100 (98% of Dry Alfalfa Forage), DAF65 (65% of Dry Alfalfa Forage), FSF100 (100% of Fresh Sulla Forage) and FSF65 (65% of Fresh Sulla Forage). Blood samples were analyzed for superoxide dismutase (SOD) and glutathione peroxidase (GPX) activity, reactive oxygen metabolites (ROMs), biological antioxidant potential (BAP) and non-esterified fatty acids (NEFA), beta-hydroxybutyrate (BHBA), albumin, glucose and cholesterol contents. The oxidative stress index (OSI) was calculated as percentage ratio of ROMs to BAP. Redox balance was improved by Sulla inclusion, as reflected in the lower OSI values found in FSF100 and FSF65 groups. DAF100 group displayed the highest GPX activity, while other groups exhibited the highest SOD activity. Fresh forage diets increased albumin concentration while no effect of tested factors was noted on glucose, NEFA, BHBA and cholesterol contents. The interaction diet × genotype was significant only for GPX activity. GPX and albumin were negatively correlated and were correlated positively and negatively with ROMs, respectively. Diet rather than genotype affects redox balance in dairy goats and a possible role of forage polyphenol compounds on oxidative status needs to be tested in future studies.

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“…Aydın and Köse (2015) reported that MDA serum concentrations in Saanen goats decreased significantly during pregnancy and lactation compared to pre-pregnancy values and reached the lowest value in the 3 rd month of pregnancy, while AO levels reached the highest value in the same periods. Karapehlivan et al (2013) found that TAS levels were lower in early lactation goats compared to late lactation goats, while TOS and OSI levels were significantly higher. The same researchers reported that there were significant differences in MDA levels between early and late lactation periods of goats (Karapehlivan et al 2013).…”

Section: Resultsmentioning

confidence: 84%

“…Karapehlivan et al (2013) found that TAS levels were lower in early lactation goats compared to late lactation goats, while TOS and OSI levels were significantly higher. The same researchers reported that there were significant differences in MDA levels between early and late lactation periods of goats (Karapehlivan et al 2013).…”

Section: Resultsmentioning

confidence: 84%

Effect of Vitamin C at Different Doses on the Oxidant/Antioxidant System of Ewes During Late Pregnancy, Early and Late Lactation and Their Lambs

Gürgöze¹,

Alak²,

Durak³

2023

IJAR

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Background: The development of connective tissue in the fetus during the ruminant gestation period increases the need for vitamin C, which is then further increased by the course of pregnancy and lactation. As pregnancy and lactation develop, free radicals and MDA produced as a result of oxidative stress interact with functional groups in the cell, resulting in cell damage. The oxidant/antioxidant balance at this time can be calculated using the total antioxidant status, total oxidant status and oxidative status index values. This study aimed to investigate the effect of two different doses of vitamin C on oxidative stress indicators in late gestation, early and late lactation ewes and their offspring. Methods: In the study, 48 ewes of the German Meat Merino and Akkaraman breeds that were developed by crossbreeding were employed. After breeding, four groups were formed from pregnant and non-pregnant ewes. Negative Pregnancy Control group was formed from non-pregnant ewes. Positive Pregnancy Control, Positive Pregnancy Practice 1 and Positive Pregnancy Practice 2 groups were formed from pregnant ewes. After the 90th day of pregnancy, ewes in the Negative Pregnancy Control and Positive Pregnancy Control groups received saline (0.9% NaCl, 2.5 ml) injections every week concurrently with the other pregnant groups until delivery. From the 90th day of pregnancy until birth, sheep participating in Positive Pregnancy Practices 1 and 2 received weekly injections of vitamin C (625 mg/CA, 2.5 ml and 1250 mg/CA, 5 ml, respectively). Result: In the study, no statistically significant difference was found in serum MDA, TAS, TOS and OSI levels between late pregnancy, lactation and born lambs. While none of the pregnant ewes in this study aborted, vitamin C injection significantly decreased postnatal lamb mortality. This showed that vitamin C helped pregnant ewes feel less stressed throughout pregnancy and helped lower postnatal lamb mortality. In pregnant ewes, AO-effective vitamin C supplementation has been shown to have possible beneficial effects on both maternal and offspring health, whereby the number of stillbirths was reduced by vitamin C supplementation, especially in Positive Pregnancy Practice 2 lambs.

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Erken ve Geç Laktasyon Periyodunun Keçilerde Plazma Oksidan/Antioksidan Dengesi Üzerindeki Etkileri

Cited by 4 publications

References 36 publications

Metabolic and oxidative status of West African dwarf does at different reproductive stages in southwest Nigeria

Metabolic and oxidative status of West African dwarf does at different reproductive stages in southwest Nigeria

Oxidative Status of Goats with Different CSN1S1 Genotypes Fed ad Libitum with Fresh and Dry Forages

Effect of Vitamin C at Different Doses on the Oxidant/Antioxidant System of Ewes During Late Pregnancy, Early and Late Lactation and Their Lambs

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