2015
DOI: 10.1007/s10847-015-0562-3
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Erlotinib/hydroxypropyl-β-cyclodextrin inclusion complex: characterization and in vitro and in vivo evaluation

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Cited by 17 publications
(10 citation statements)
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“…The interaction mechanisms of CDs with LGK974 were studied using isothermal titration calorimetry (ITC). ITC measures the thermodynamic changes of host-guest interactions, such as CD:drug complexes, and determines the strength of interaction (complexation constant) and stoichiometry in solution [29,30]. The average stoichiometry N of the complex in solution and its thermodynamic parameters of interaction (enthalpy ΔH°, entropy ΔS°, complexation constant K complex ) were determined.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…The interaction mechanisms of CDs with LGK974 were studied using isothermal titration calorimetry (ITC). ITC measures the thermodynamic changes of host-guest interactions, such as CD:drug complexes, and determines the strength of interaction (complexation constant) and stoichiometry in solution [29,30]. The average stoichiometry N of the complex in solution and its thermodynamic parameters of interaction (enthalpy ΔH°, entropy ΔS°, complexation constant K complex ) were determined.…”
Section: Resultsmentioning
confidence: 99%
“…The interaction between βSBECD and LGK974 is an exothermic process cooperatively accompanied by an entropy increase, leading to an especially strong interaction between the two species (K complex1:1 = 1720 ± 156 M −1 ) compared to other CD:guest systems [2931]. The interaction between HPβCD and LGK974 is also an exothermic process, but the complexation constant (K complex1:1 = 170 ± 5.49 M −1 ) is measured to be 10 times lower than that of βSBECD:LGK974, indicating a weaker host:guest interaction.…”
Section: Resultsmentioning
confidence: 99%
“…Esses compostos se destacam pela capacidade de formar compostos de inclusão com substâncias diversas, geralmente aumentando a sua solubilidade, estabilidade e atividade biológica. [11][12] O uso de ciclodextrinas como agentes de nanoencapsulamento tem sido praticado com sucesso com diversas substâncias bioativas de origem vegetal, como alcaloides, 13 ácidos fenólicos, 14 compostos polifenólicos; 15 além de misturas complexas, como extratos de folha de oliva, 16 própolis 7b e hibisco, 17 sendo essas últimas, denominadas fitocomplexos.…”
Section: Palavras-chaveunclassified
“…One of the ERL drawbacks is low water solubility, which limits its use in the development of safer and effective formulations. The study by Gontijo et al used the strategy of inclusion complexation with hydroxypropyl-β-cyclodextrin (HP-β-CD) to increase the ERL water solubility [11]. Despite free ERL higher cytotoxicity, higher values were associated with the complex compared with free ERL (37.5 μM) and the complex was more cytotoxic to A431 human epidermoid carcinoma cell than to osteoblasts (non-cancerous cells).…”
Section: Introductionmentioning
confidence: 99%