Erlotinib-loaded carboxymethyl temarind gum semi-interpenetrating nanocomposites

Bera, Hriday; Abbasi, Yasir Faraz; Ping, Law Lee; Marbaniang, Daphisha; Mazumder, Bhaskar; Kumar, Pramod; Tambe, Prajakta; Gajbhiye, Virendra; Cun, Dongmei; Yang, Mingshi

doi:10.1016/j.carbpol.2019.115664

Cited by 24 publications

(9 citation statements)

References 28 publications

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“…Mesoporous silica nanoparticles (MSN) are excellent drug carriers owing to the porosity and have been used for highly efficient loading of EGFR-TKIs. ,, Similarly, montmorillonite (MMT), a nanoclay mineral with excellent sorption at the interlayer space and outer surface and edges, was leveraged to improve the loading efficiently of Erlo, where Erlo loading capacity was positively dependent on the MMT content and a 99% Erlo entrapping capacity was obtained at a 20% MTT feeding amount . The combination of MTT with thermos-sensitive polymer, PNIPAM, further dictates thermosensitive Erlo release. , Superparamagnetic Fe 3 O 4 NPs have been used to monitor the delivery efficiency of Erlo through noninvasive MRI. , In addition, NIR-absorbing, inorganic nanomaterials-based hybrid NPs can further allow photomodulated drug release and combinational cancer therapy . For example, Au nanoshells with a SiO 2 core were conjugated to human serum albumin or DNA that acted as host to load Lapa, and the drug release was remotely controlled by continuous wave or pulsed irradiation …”

Section: Ddss For Enhanced Egfr-tki Deliverymentioning

confidence: 99%

“…104 The combination of MTT with thermos-sensitive polymer, PNIPAM, further dictates thermosensitive Erlo release. 104,105 Superparamagnetic Fe 3 O 4 NPs have been used to monitor the delivery efficiency of Erlo through noninvasive MRI. 106,107 In addition, NIR-absorbing, inorganic nanomaterials-based hybrid NPs can further allow photomodulated drug release and combinational cancer therapy.…”

Section: Polymer Npsmentioning

confidence: 99%

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Recent Advances in Boosting EGFR Tyrosine Kinase Inhibitors-Based Cancer Therapy

Pan

et al. 2023

Mol. Pharmaceutics

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Epidermal growth factor receptor (EGFR) plays a key role in signal transduction pathways associated with cell proliferation, growth, and survival. Its overexpression and aberrant activation in malignancy correlate with poor prognosis and short survival. Targeting inhibition of EGFR by small-molecular tyrosine kinase inhibitors (TKIs) is emerging as an important treatment model besides of chemotherapy, greatly reshaping the landscape of cancer therapy. However, they are still challenged by the offtargeted toxicity, relatively limited cancer types, and drug resistance after long-term therapy. In this review, we summarize the recent progress of oral, pulmonary, and injectable drug delivery systems for enhanced and targeting TKI delivery to tumors and reduced side effects. Importantly, EGFR-TKI-based combination therapies not only greatly broaden the applicable cancer types of EGFR-TKI but also significantly improve the anticancer effect. The mechanisms of TKI resistance are summarized, and current strategies to overcome TKI resistance as well as the application of TKI in reversing chemotherapy resistance are discussed. Finally, we provide a perspective on the future research of EGFR-TKI-based cancer therapy.

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Section: Ddss For Enhanced Egfr-tki Deliverymentioning

confidence: 99%

Section: Polymer Npsmentioning

confidence: 99%

Recent Advances in Boosting EGFR Tyrosine Kinase Inhibitors-Based Cancer Therapy

Pan

et al. 2023

Mol. Pharmaceutics

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“…11 The calculated n values signified that the PTX release from NPs was mostly driven by anomalous diffusion under both conditions. 2 Exceptionally, a Fickian diffusion phenomenon was dominated for the drug release patterns of TF−PULL−SS−PTX NPs under the reduction state. Thus, PTX molecules were typically released via both polymer chain relaxation and diffusion processes.…”

Section: Synthesis and Characterization Of Pull−cc−ptx And Pull−ss−ptxmentioning

confidence: 99%

“…1 The vast majority of lung cancer cases are diagnosed at extremely advanced or inoperable metastatic stages, where chemotherapy remains as the primary treatment option. 2 Paclitaxel (PTX) is the cornerstone chemotherapy for the lung cancer treatment and often used in combination with other anticancer drugs. 3 PTX stabilizes microtubules by blocking their depolymerization during the cell division.…”

Section: Introductionmentioning

confidence: 99%

“…Lung carcinoma continues to be the leading cause of premature mortality across the globe, accounting for approximately one in five deaths (1.59 million deaths and 19.4% of the total) . The vast majority of lung cancer cases are diagnosed at extremely advanced or inoperable metastatic stages, where chemotherapy remains as the primary treatment option . Paclitaxel (PTX) is the cornerstone chemotherapy for the lung cancer treatment and often used in combination with other anticancer drugs .…”

Section: Introductionmentioning

confidence: 99%

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Engineering Transferrin-Decorated Pullulan-Based Prodrug Nanoparticles for Redox Responsive Paclitaxel Delivery to Metastatic Lung Cancer Cells

Zhao

Guo

Bera

et al. 2023

ACS Appl. Mater. Interfaces

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Paclitaxel (PTX) remains a cornerstone in the treatment of locally advanced and metastatic lung cancer. To improve its therapeutic indices against lung cancer, novel redox-sensitive pullulan/PTX-based prodrug NPs (PULL–SS–PTX NPs) were accomplished, which were further surface-decorated with transferrin (TF), a cancer cell-targeting ligand, to afford TF–PULL–SS–PTX NPs. These prodrug NPs (drug content, >37% and average size, 134–163 nm) rapidly dismantled their self-assembled architecture upon exposure to simulated reducing conditions, causing a triggered drug release as compared to the control scaffold (PULL–CC–PTX NPs). These scaffolds also evidenced outstanding colloidal stability, cellular uptake efficiency, and discriminating cytotoxicity between the cancer and healthy cells. Intravenously delivered redox-sensitive NPs exhibited improved tumor-suppressing properties as compared to the control nanovesicles (PULL–CC–PTX NPs) in a B16–F10 melanoma lung metastasis mice model. The targeting efficiency and associated augmented anticancer potentials of TF–PULL–SS–PTX NPs relative to TF-free redox-responsive NPs and Taxol intravenous injection were also established on the transferrin receptor (TFR) overexpressed Lewis lung carcinoma (LLC–luc) cell-bearing mice model. Moreover, the TF-functionalized scaffold displayed a reduced systemic toxicity compared to that of Taxol intravenous injection. Overall, the proposed TF-decorated prodrug NPs could be a promising nanomedicine for intracellular PTX delivery against metastatic lung cancer.

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Layered Clay Minerals in Cancer Therapy: Recent Progress and Prospects

Xie

Chen

Yang

2023

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Cancer is one of the deadliest diseases, and current treatment regimens suffer from limited efficacy, nonspecific toxicity, and chemoresistance. With the advantages of good biocompatibility, large specific surface area, excellent cation exchange capacity, and easy availability, clay minerals have been receiving ever‐increasing interests in cancer treatment. They can act as carriers to reduce the toxic side effects of chemotherapeutic drugs, and some of their own properties can kill cancer cells, etc. Compared with other morphologies clays, layered clay minerals (LCM) have attracted more and more attention due to adjustable interlayer spacing, easier ion exchange, and stronger adsorption capacity. In this review, the structure, classification, physicochemical properties, and functionalization methods of LCM are summarized. The state‐of‐the‐art progress of LCM in antitumor therapy is systematically described, with emphasis on the application of montmorillonite, kaolinite, and vermiculite. Furthermore, the property–function relationships of LCM are comprehensively illustrated to reveal the design principles of clay‐based antitumor systems. Finally, foreseeable challenges and outlook in this field are discussed.

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Erlotinib-loaded carboxymethyl temarind gum semi-interpenetrating nanocomposites

Cited by 24 publications

References 28 publications

Recent Advances in Boosting EGFR Tyrosine Kinase Inhibitors-Based Cancer Therapy

Recent Advances in Boosting EGFR Tyrosine Kinase Inhibitors-Based Cancer Therapy

Engineering Transferrin-Decorated Pullulan-Based Prodrug Nanoparticles for Redox Responsive Paclitaxel Delivery to Metastatic Lung Cancer Cells

Layered Clay Minerals in Cancer Therapy: Recent Progress and Prospects

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