When sand particles are entrained into carrier flow, such as liquid, a strong interaction occurs with the surface of the metallic material, resulting in serious erosion damage. However, the effect of the physical properties of particles and materials on erosion characteristics has not been well studied. In this paper, the erosion-wear behavior of a rotating disc surface under the action of solid–liquid two-phase flow was studied by using the discrete particle model (DPM). The wear effects on the surface of sample due to particle diameter (d = 0.1 mm, d = 0.2 mm, d = 0.3 mm, d = 0.4 mm), particle volume fraction (CV = 2%, CV = 3%, CV = 4%, CV = 5%), and particle inlet velocity (v = 1.05 m/s, v = 2.05 m/s, v = 3.05 m/s, v = 4.05 m/s) were analyzed using representative values of operating conditions of rotating machines. The results show that the wear amount increases exponentially with the radius, whilst the maximum wear amount increases faster than the average wear amount with the particle volume fraction. The surface wear grows inversely with the particle diameter but slightly with the particle inlet velocity. A case study of stainless steel samples at different radius positions on the surface of rotating disc is carried out using a mixed velocity of sand and water of 2.05 m/s, an average particle size of 0.1 mm, and a concentration of CV = 2.5%. The experiments show the wear amount increases with the radius on the surface of the rotating disc, just as predicted by the numerical simulation. Two important findings emerge from the study: (1) the wear morphology of the specimen surface develops from two to three regions; (2) when the basal body is rotating at high speed, the wear degree is influenced more by the circumferential than particle inlet velocity. The wear morphology was observed by using a scanning electron microscope (SEM). It exhibited a mixture of fine and coarse scratches and pits, and the distribution of these varied according to the radial distance of the disc.