The Yarlung Tsangpo-Brahmaputra river drains a large portion of the Himalaya and southern Tibetan plateau, including the eastern Himalayan syntaxis, one of the most tectonically active regions on the globe. We measured the solute chemistry of 161 streams and major tributaries of the Tsangpo-Brahmaputra to examine the effect of tectonic, climatic, and geologic factors on chemical weathering rates. Specifically, we quantify chemical weathering fluxes and CO 2 consumption by silicate weathering in southern Tibet and the eastern syntaxis of the Himalaya, examine the major chemical weathering reactions in the tributaries of the Tsangpo-Brahmaputra, and determine the total weathering flux from carbonate and silicate weathering processes in this region. We show that high precipitation, rapid tectonic uplift, steep channel slopes, and high stream power generate high rates of chemical weathering in the eastern syntaxis. The total dissolved solids (TDS) flux from the this area is greater than 520 tons km À2 yr À1 and the silicate cation flux more than 34 tons km À2 yr À1 . In total, chemical weathering in this area consumes 15.2 · 10 5 mol CO 2 km À2 yr À1 , which is twice the Brahmaputra average. These data show that 15-20% of the total CO 2 consumption by silicate weathering in the Brahmaputra catchment is derived from only 4% of the total land area of the basin. Hot springs and evaporite weathering provide significant contributions to dissolved Na + and Cl À fluxes throughout southern Tibet, comprising more than 50% of all Na + in some stream systems. Carbonate weathering generates 80-90% of all dissolved Ca 2+ and Mg 2+ cations in much of the Yarlung Tsangpo catchment.