Erosion of X-Chromosome Inactivation in female hiPSCs is heterogeneous and persists during differentiation
Ana Cláudia Raposo,
Paulo Caldas,
Maria Arez
et al.
Abstract:During culture, female human pluripotent stem cells (hPSCs), including human induced PSCs (hiPSCs) exhibit a propensity for erosion of X-chromosome inactivation (XCI). This phenomenon is characterized by loss of XIST RNA expression and reactivation of a subset of X-linked genes from the inactive X chromosome (Xi). XCI erosion, despite its common occurrence, is often overlooked by the stem cell community, hindering a complete understanding of its impact on both fundamental and translational applications of hiPS… Show more
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