Erosive osteoarthritis of the hands

We studied 10 patients who had arthritis of the knee joint, but no other signs of rheumatic disease. The clinical diagnosis of osteoarthritis was corroborated by arthroscopic evidence of characteristic cartilage degeneration. Signs of inflammation were confined to areas of the synovial membrane that lay near the cartilage; thus, the major part of the joint cavity was not affected. The intensity of the synovial inflammation varied within the areas involved, but was always most pronounced in regions rimming the cartilage. Biopsy samples selected from regions of intensely inflamed synovium contained foci of T lymphocytes, which were bordered by immunoglobulin‐carrying B lymphocytes and plasma cells, as well as strongly HLA‐DR positive dendritic‐like cells adjoined to αLeu − 3a + T helper lymphocytes. In tissue samples taken from macroscopically noninflamed areas, only a few infiltrating lymphocytes were seen. Thus, the inflammatory synovial changes found in osteoarthritis appear to be anatomically restricted and of varied intensity but, when present, are microscopically indistinguishable from the changes that have been previously described as indicative of rheumatoid arthritis.

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“…LINDBLAD AND HEDFORS have revealed that prominent inflammatory changes of the synovial membrane are also present in OA (14)(15)(16).…”

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confidence: 99%

Arthroscopic and immunohistologic characterization of knee joint synovitis in osteoarthritis

Lindblad

Hedfors

1987

Arthritis & Rheumatism

150

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“…In Radi's investigation (1970) all 21 cases were sero-negative for rheumatoid arthritis. The same has been encountered in other reports (Crain 1961, Peter et al 1966, McEwen 1968. This in itself does not exclude the possibility of a rheumatoid agent being active in the development of the digital destructions but does not on the other hand give the concept any strength.…”

Section: Discussionmentioning

confidence: 57%

“…On perusing the literature it appears that many authors belive in a relationship to rheumatoid arthritis (e.g. Peter et al 1966, McEwen 1968) though definite evidence for this assumption is lacking. The histologic report of Peter and co-workers (1966) exposes close similarities to the morphologic appearance of rheumatoid synovium.…”

Section: Discussionmentioning

confidence: 99%

“…Further studies by Peter et al (1966), including histologic analysis of specimens from 6 patients with degenerative disease of both proximal and distal finger joints, disclosed that synovium from these joints resembled that of rheumatoid arthritis much more closely than that of chronic osteoarthritis. In view of negative serologic tests Peter et al suggested the term "erosive osteoaorthritis" to be used for this condi- tion, as cartilage destruction, juxta-articular erosions and osteophyte formation were so predominant.…”

mentioning

confidence: 98%

“…Clinically there is a resemblance to rheumatoid arthritis, but laboratory findings fail to give satisfactory proof of this condition and no other joint involvement can be demonstrated (Peter et al 1966, McEwen 1968, Radi 1970). …”

mentioning

confidence: 99%

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