Erosive pustular dermatosis in a patient with lichen planopilaris treated with aminolevulinic acid photodynamic therapy

Light, Jeremy G.; Bomar, Leonora; McMichael, Amy J.

doi:10.1016/j.pdpdt.2021.102207

Cited by 3 publications

(12 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Study characteristics were summarized in Table 1. A total of 25 papers consisted of 9 case reports [16,18,19,[31][32][33][34][35][36], 5 pilot study [17,29,[37][38][39], 3 case series [40][41][42], 5 randomized controlled trials[28, [43][44][45][46] and 3 prospective observational studies [47][48][49]. Across the 25 included articles, a total of 335 patients were enrolled in all studies, ranging in age from 15 to 93 years.…”

Section: Methodsmentioning

confidence: 99%

“…The improvement of wound healing by PDT may be mainly attributed to its microbicidal effect. Literature support the antibacterial use of PDT in bacterial infections where conventional treatment has failed [16][17][18][19]. The potential of PDT antimicrobial therapy involves the management of superficial pathogens including fungi, bacteria and mycoplasma.…”

Section: ____________________________________________________________...mentioning

confidence: 99%

“…Data on this table showed that studies assessed the clinical application of ALA-PDT on different types of human skin wounds, including six studies of skin cancers [31,33,36,37,43,44], five studies of chronic leg ulcers[28, 29,31,39,46], three studies of erosive pustular skin diseases [16,38,42], and two studies of bilateral erosive oral lichen planus symptoms [40,41].…”

Section: Disease Profilementioning

confidence: 99%

“…The mean age of subjects was about In terms of population distribution of patients, skin cancers (105 patients) [31,33,36,37,43,44], leg and foot ulcers (62 patients) [28, 29,31,39,46] and anal fistula (59 patients) [48,49] were the most common diseases in the population, while carbuncle [32], chromosomiasis [18], leishmaniasis [34], hidradenitis suppurativa [35], and ulcerative necrobiosis lipoidica [19] were only a small subset with only one case in each study. CO2 laser injury (33 patients) [47], erosive oral lichen planus (22 patients) [40,41], Bowen's disease (BP) (18 patients) [45], erosive pustular dermatosis (14 patients) [16,38,42], furuncle and abscess (4 patients) [17], trauma (3 patients) [17] were moderate.…”

Section: Number Distribution Of Patientsmentioning

confidence: 99%

“…The ALA forms used in this systematic review varied by solutions, emulsions, creams, gels and ointments. ALA solutions were used in the majority of studies (14 studies, 182 subjects) [16,29,31,32,37,[42][43][44][45][46][47]49], followed by ALA gels (5 studies, 91 subjects) [33,34,[38][39][40][41]48], emulsions (2 studies, 17 subjects) [17,28], creams (3 studies, 3 subjects) [18,35,36], and ointments (1 study, 1 subject) [19]. This might be due to the superior homogeneity and cutaneous permeability of the solution compared to creams or gels [52].…”

Section: Photosensitizer Formulationmentioning

confidence: 99%

See 4 more Smart Citations

5-Aminolevulinic Acid-Mediated Photodynamic Therapy on Wound Healing: A Systemic Review of Human Evidences

Huang,

Wang

2023

Journal of the American Podiatric Medical Association

View full text Add to dashboard Cite

Backgrounds: Skin wounds are a kind of refractory disease frequently encountered in clinic, which brings enormous burden to patients. Great efforts to address the dilemma of wound healing have yielded some encouraging results, but they are still unsatisfactory. 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) has been developed as a promising noninvasive treatment for skin wounds. A systematic review was performed to determine the existing evidence base for the clinical use of ALA-PDT on refractory wounds. Methods: We conducted a PubMed search for English literature related to the clinical treatment of human skin ulcers by ALA-PDT published from 2012 to 2022, and performed a systematic review. Results: 25 studies were ultimately selected in the present review and summarized, including six studies of skin cancer, five studies of chronic leg ulcers, three studies of erosive pustular skin diseases, and two studies of erosive oral lichen planus symptoms. A total of 335 patients had approximately 355 ulcers, of which 315 ulcers received photodynamic therapy and 276 improved with ALA-PDT. 20% ALA solution, wavelength between 600 nm and 670 nm, energy density of 120 J/cm2, frequency of once per week and 3 sessions were the most selected therapeutic parameters. Generally, ALA-PDT for wounds was effective with main adverse events of mild to moderate pain, and follow-up was generally conducted within 1 year. Conclusions: This systematic review summarized the commonly used therapeutic parameters for ALA-PDT in the clinical treatment of skin wounds. After ALA-PDT alone or ALA-PDT combined with curettage, antibacterial and surgical treatment, all wounds healed well, and the adverse reactions were mainly mild to moderate pain, which could be relieved by cooling. ALA-PDT had proven to be a promising wound treatment modality through evidence of safety and efficacy.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: ____________________________________________________________...mentioning

confidence: 99%

Section: Disease Profilementioning

confidence: 99%

Section: Number Distribution Of Patientsmentioning

confidence: 99%

Section: Photosensitizer Formulationmentioning

confidence: 99%

See 3 more Smart Citations

5-Aminolevulinic Acid-Mediated Photodynamic Therapy on Wound Healing: A Systemic Review of Human Evidences

Huang,

Wang

2023

Journal of the American Podiatric Medical Association

View full text Add to dashboard Cite

show abstract

Principles of Photodynamic Therapy

Ibbotson,

McKenna

2024

Rook's Textbook of Dermatology

View full text Add to dashboard Cite

Topical photodynamic therapy (PDT) is widely used as an effective and well‐tolerated treatment for field change actinic keratosis, Bowen disease and superficial basal cell carcinoma. There is a strong evidence base to support its use and guidelines, which summarise the evidence and clinical utility of this therapy. There are also standards available for guidance with respect to establishing PDT services in dermatology and emphasis is placed on the availability of PDT for practitioners affiliated with a skin cancer multi‐disciplinary team. Developments in photosensitisers and light delivery, such as through the increasing application of daylight PDT, have greatly improved the tolerance, acceptability and uptake of PDT, such that this should be widely available through dermatology services. Further refinements in photosensitiser and light delivery will be expected to continue to improve PDT outcomes and the uptake of this invaluable therapeutic approach.

show abstract