Erosive pustular dermatosis of the scalp: Clinical, trichoscopic, and histopathologic features of 20 cases

Starace, Michela; Loi, Camilla; Bruni, Francesca; Alessandrini, Aurora; Misciali, Cosimo; Patrizi, Annalisa; Piraccini, Bianca Maria

doi:10.1016/j.jaad.2016.12.016

Cited by 61 publications

(130 citation statements)

References 17 publications

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“…None of the patients had a history of actinic damage. The adolescent cases presented very similarly to the few cases described in young adults . Overall, the appearance of the lesions was consistent with the classic description of EPDS: All described cases involved crusting at or adjacent to sites of previous trauma, and most also developed pustules, ulcers, or erosions.…”

Section: Discussionsupporting

confidence: 79%

“…Erosive pustular dermatosis of the scalp (EPDS) is a chronic condition typically presenting with pustules, erosions, and crusting following scalp trauma . Triggers include trauma, surgery, phototherapy, radiation, and various topical and systemic medications . Initially thought to be a disorder strictly affecting the elderly with actinic damage, more recent reports have described the condition in infants and adolescents following scalp trauma .…”

Section: Introductionmentioning

confidence: 99%

“…Rather, the most effective therapies include high‐potency topical corticosteroids and calcineurin inhibitors. This observation, along with the association of EPDS with autoimmune disorders, suggests that EPDS may represent a dysregulated autoimmune response to skin antigens following trauma . Resolution of active lesions with cicatricial alopecia is the rule, and significant hair regrowth has rarely been described …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Erosive pustular dermatosis of the scalp in an adolescent with near‐total hair regrowth: Case report and review of the literature

Teng

Taylor

et al. 2019

Pediatric Dermatology

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Erosive pustular dermatosis of the scalp (EPDS) is an uncommon chronic inflammatory response to scalp trauma that usually resolves with cicatricial alopecia. It most commonly affects elderly patients with a history of actinic damage. Herein, we describe a 16‐year‐old girl with acrofacial dysostosis type 1 presenting after surgery with crusting purulent scalp lesions, whose clinical presentation and histopathologic findings were consistent with EPDS. A review of the literature on EPDS in children is also detailed.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Erosive pustular dermatosis of the scalp in an adolescent with near‐total hair regrowth: Case report and review of the literature

Teng

Taylor

et al. 2019

Pediatric Dermatology

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“…Hair follicles with their characteristic low-surface major histocompatibility complex (MHC) are classified as an immune privilege site, a title mainly attributed to several vital organs including the brain, testes, and cornea [20]. EPD may have an association with other autoimmune diseases [1,21]. Recently, regulatory T cells (Treg), important for immune homeostasis, have been shown to preferentially localize to hair follicles [22,23].…”

Section: Discussionmentioning

confidence: 99%

Erosive Pustular Dermatosis: A Manifestation of Immunosenescence A Report of 8 Cases

Thuraisingam

Mirmirani

2017

Skin Appendage Disord

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Erosive pustular dermatosis (EPD) is a rare condition of the scalp and legs that is marked by crusted erosions or superficial ulcerations that may result in scarring alopecia and chronic wounds. The condition predominantly affects elderly female as compared to male patients. Its pathogenesis remains poorly understood. The majority of the cases in the literature are from the United Kingdom and continental Europe. In this series, we present 8 North American patients with EPD of the scalp, one of whom also had involvement of the legs and another with the involvement of the face. All our patients were advanced in age and had a predisposition to chronic actinic damage, which are common characteristics of EPD previously reported in the literature. We hypothesize that immunosenescence leads to an aberrant immune response to wound healing and, along with other factors such as a loss of the normal epidermal barrier, ultraviolet damage, and hormonal factors, may contribute to the development of this condition.

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“…The course is typically chronic and poorly responsive to treatments [2]. A beefy red coloration is characteristic [3].…”

Section: Answermentioning

confidence: 99%

Cicatricial Alopecia after a Surgical Procedure

Brito

Pereira

Kakizaki

et al. 2017

Skin Appendage Disord

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Erosive pustular dermatosis of the scalp: Clinical, trichoscopic, and histopathologic features of 20 cases

Cited by 61 publications

References 17 publications

Erosive pustular dermatosis of the scalp in an adolescent with near‐total hair regrowth: Case report and review of the literature

Erosive pustular dermatosis of the scalp in an adolescent with near‐total hair regrowth: Case report and review of the literature

Erosive Pustular Dermatosis: A Manifestation of Immunosenescence A Report of 8 Cases

Cicatricial Alopecia after a Surgical Procedure

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