Erosive pustular dermatosis of the scalp induced by gefitinib: case and review of the literature

Nazzaro, Gianluca; Giacalone, Serena; Bortoluzzi, Paolo; Veraldi, Stefano; Marzano, Angelo Valerio

doi:10.5070/d3272052385

Cited by 10 publications

(7 citation statements)

References 26 publications

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“…Loss of immune privilege causes increased expression of genes for pro-inflammatory cytokines which precipitates alopecia. 1 It is worth mentioning that almost all cases of erosive pustular dermatosis caused by EGFR inhibitors have been reported in females, barring one case which was reported in an 84-year-old male on gefitinib by Nazzaro et al 1 The basis of gender predilection in these cases warrants further research.…”

Section: Discussionmentioning

confidence: 96%

“…Loss of immune privilege causes increased expression of genes for pro-inflammatory cytokines which precipitates alopecia. 1…”

Section: Discussionmentioning

confidence: 99%

“…This receptor is present in the normal skin epithelium and the follicular cells besides the cancer cells. 1 Therefore, EGFR inhibitors decrease the growth of cancerous cells but also cause a variety of mucocutaneous adverse effects. The most frequent cutaneous complication during therapy is an acneiform papulopustular eruption that most commonly involves the seborrheic regions.…”

Section: Introductionmentioning

confidence: 99%

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Erosive pustular dermatosis of the scalp secondary to Erlotinib: A rare occurrence with trichoscopic perspective

Gupta,

Chopra,

Preeyati

2023

Journal of the Royal College of Physicians of Edinburgh

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Epidermal growth factor receptor inhibitors are anti-tumour agents that are frequently used for the treatment of neoplastic disorders. In addition to their cutaneous adverse effects, these drugs can rarely lead to erosive pustular dermatosis of the scalp. We report a case of a 67-year-old female who developed erosive pustular dermatosis of the scalp after being started on erlotinib from a trichoscopic perspective, which has been described in literature only once till now.

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Section: Discussionmentioning

confidence: 96%

“…Loss of immune privilege causes increased expression of genes for pro-inflammatory cytokines which precipitates alopecia. 1…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Erosive pustular dermatosis of the scalp secondary to Erlotinib: A rare occurrence with trichoscopic perspective

Gupta,

Chopra,

Preeyati

2023

Journal of the Royal College of Physicians of Edinburgh

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“…The provoking or triggering factors for erosive pustular dermatosis are different, often confusing for the clinician and include in turn: certain drug triggers, namely – after or within panitumumab therapy, 5 after local oxygen therapy, 6 after photodynamic aminolevulinic acid therapy, 7 treatment with gefitinib, 8 nivolumab, 9 sirolimus, 10 topical imiquimod, 11 ingenol mebutate, 12 and latanoprost. 13 …”

Section: Discussionmentioning

confidence: 99%

“…The opinion regarding the application of photodynamic therapy with aminolevulinic acid, as well as the surgical approach, should be considered with particular attention as possible therapeutic options, since there are conflicting clinical observations in the literature that describe these two options as more of a triggering/inducing factor. 8 , 34-38 …”

Section: Discussionmentioning

confidence: 99%

Erosive pustular dermatosis of the scalp: a pathogenetic мystery and therapeutic challenge

Tchernev¹,

Kordeva²,

Batashki³

et al. 2022

Dermatol Reports

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Erosive pustular dermatosis of the scalp (EPDS) is a rare condition which affects predominantly the adult population, and occurs on a previously photo-damaged bald scalp. The physical examination is presented with a large erythematous, erosive and crusted patches with granulation on an atrophic skin. The problem in patients with erosive pustular dermatosis of the scalp arises from the nonspecific clinical and histopathological findings, which can be misleading. Biopsy followed by careful histopathological verification is mandatory, although the finding is nonspecific.The histopathology findings are characterized by superficial erosions with mild neutrophil infiltrate, mainly intravascular and focally with neutrophil exocytosis. Focal parakeratosis, smoothed rete ridges without pronounced interface changes. Pronounced lymphoplasmacytic infiltrate with focal distribution in the dermis, giant cell reaction with the formation of a “foreign body” granuloma. We report a 58-year old male patient with a 1 year old lesion, suspected for skin cancer, later diagnosed with EPDS, which was successfully treated with topical clobetasol proprionate after 3-5 weeks.

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Drug-induced scarring and permanent alopecia

Perez,

Nguyen,

Tosti

2024

JAAD Reviews

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Erosive pustular dermatosis of the scalp induced by gefitinib: case and review of the literature

Cited by 10 publications

References 26 publications

Erosive pustular dermatosis of the scalp secondary to Erlotinib: A rare occurrence with trichoscopic perspective

Erosive pustular dermatosis of the scalp secondary to Erlotinib: A rare occurrence with trichoscopic perspective

Erosive pustular dermatosis of the scalp: a pathogenetic мystery and therapeutic challenge

Drug-induced scarring and permanent alopecia

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