Erosive pustular dermatosis of the scalp: A neutrophilic folliculitis within the spectrum of neutrophilic dermatoses

Tomasini, Carlo Francesco; Michelerio, Andrea

doi:10.1016/j.jaad.2018.10.029

Cited by 29 publications

(45 citation statements)

References 28 publications

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“…Dear Editor Erosive pustular dermatosis (EPD) is a rare condition that typically affects skin with actinic damage of the scalp, characterized by sterile pustules, erosions and crusts leading to scarring alopecia. [1][2][3] Here, we present the case of a 94-year-old female patient admitted to our clinic with a clinical history of not-symptomatic persistent facial and scalp erosions for 2-3 years without identifiable causes or prior traumatic and cosmetic procedures. A previous biopsy, performed in another centre, gave non-specific results showing inflammatory lymphocytic infiltration on the upper dermis.…”

Section: Erosive Pustular Dermatosis: Not Only Scalpmentioning

confidence: 99%

“…The histopathologic features of EPD could explain the pathogenesis: a dual association with physical injuries and autoimmunity may suggest the production of autoantibodies against skin antigens, which then produce a secondary inflammatory response made by neutrophils and lymphocytes with a release of inflammatory cytokines responsible for the skin damages. 2,4,6 The diagnosis of EPD is challenging, as it shares clinical and histological features with other pustular disorders, like pustular psoriasis or primary infectious pustules. Trichoscopy has been reported as a valid non-invasive diagnostic tool allowing to detect specific features of EPD: follicular crusts, keratotic plugging and erosions, milky red areas, white patches, hair shafts broken a few millimetres above the scalp, tapering hair, hair tufting (with no more than four hairs emerging from the same unit) and absence of follicular openings with skin atrophy.…”

Section: Erosive Pustular Dermatosis: Not Only Scalpmentioning

confidence: 99%

“…10 Increased levels of these early induced proinflammatory mediators have been found in HS skin. [1][2][3][4][5][6] Further, S100A15 acts as a chemotactic factor for neutrophils and…”

Section: Erosive Pustular Dermatosis: Not Only Scalpmentioning

confidence: 99%

See 2 more Smart Citations

Erosive pustular dermatosis: not only scalp

Gallo

Ribero

Conti

et al. 2020

Acad Dermatol Venereol

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constitutes one of the most important problems in the use of sequential digital monitoring. 5 This problem must be taken into consideration in the final analysis of the study data and must be regarded as a highly dangerous event because it involves leaving in the patient a melanoma that in the predigital era would have been removed. 4 Another important bias in patient selection is the exclusion of patients in which the images collected ('poor image quality') did not allow for a safe analysis at the checks, such as whether cases were excluded in traditional 'clinical trial' because they could not be diagnosed by the called 'naked eye'. In our opinion, these cases must not be excluded but even analysed deeply. Technology use must be accompanied by an analysis of its limits or difficulties, Therefore, we are of the opinion that these exclusions do not represent reality, and therefore, the authors did not calculate the sensitivity and specificity of the method in a manner comparable with real practice. Furthermore, we do not understand the utility and safety of the assistant nurse. If a patient is returned for short-term monitoring (after only 3-4 months), it means that the patient has a high-risk lesion. These patients must be managed by a particularly experienced dermatologist and not by a nurse who can only photograph the suspicious lesion. Using a nurse runs the risk of losing the patient not only from follow-up but also from excision. The dermatologist can immediately explain the importance and necessity of excision to the patient, unlike the nurse, a phone call or a letter he receives at home. Thus, we are sure that short-term teledermoscopic monitoring will play an important role in the early diagnosis of melanoma in the future. However, at present, it is key to have evidence-based studies that simulate clinical practice and can provide fully convincing data about short-term teledermoscopic monitoring's role in melanoma screening.

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Section: Erosive Pustular Dermatosis: Not Only Scalpmentioning

confidence: 99%

Section: Erosive Pustular Dermatosis: Not Only Scalpmentioning

confidence: 99%

See 1 more Smart Citation

Erosive pustular dermatosis: not only scalp

Gallo

Ribero

Conti

et al. 2020

Acad Dermatol Venereol

View full text Add to dashboard Cite

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“…1 It is a non infectious inflammation of the skin, generally the scalp or legs, associated with chronic ultraviolet damage (in this case, previous radiotherapy may have been involved) and subsequent skin trauma. 2 Systemic antibiotics (to treat any associated infection) and corticosteroids may be required; 3 however, in this patient, topical treatment with clobetasol 0.05% and fusidic acid 2% ointments (1:1) used twice daily for 1 month produced excellent improvement ( Figure 2). This was followed by hydrocortisone acetate 2.5% and fusidic acid 2% ointments (1:1) applied 3 times daily to complete resolution over the following 2 months.…”

mentioning

confidence: 91%