ERP and behavioral indices of working memory dysfunction in schizophrenia

Javitt, D.C.; Shelley, A-M.; Leiderman, Eduardo A; March, Lucy; Cowan, Naomi; Ritter, Walter

doi:10.1016/0006-3223(96)84172-2

Cited by 2 publications

(2 citation statements)

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“…In contrast to the suggestion by Oades, pitch MMN deficits have now been demonstrated in several subjects in which difficult distractor tasks have been employed [Alain et al, 1998a;Javitt et al, 1999;Kasai et al, 1999]. Further, in the study by Alain et al, the amplitude of MMN (subtraction) waveforms to pitch-deviant stimuli recorded at Fz from control and schizophrenic subjects at indicated levels of probability and ISI.…”

Section: Role Of Attentionmentioning

confidence: 92%

“…Several studies have now demonstrated that schizophrenic subjects are severely impaired in sensory memory performance [Holcomb et al, 1995;Javitt et al, 1997Javitt et al, , 1999March et al, 1999;Strous et al, 1995;Wexler et al, 1998]. Chronic schizophrenic subjects require, on average, a difference of 20% in pitch to perform as well as controls perform at a 5% level of ¢f.…”

Section: Relationship Between Mmn Deficits and Auditory Sensory ('Echmentioning

confidence: 99%

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Intracortical Mechanisms of Mismatch Negativity Dysfunction in Schizophrenia

2000

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Event-related potentials provide an objective index of neurocognitive dysfunction in schizophrenia. Schizophrenia subjects show a decreased mismatch negativity (MMN) amplitude relative to age- and sex-matched controls, along with a characteristic pattern of MMN dysfunction across conditions. Deficits in MMN generation are accompanied by (1) impaired precision of auditory sensory memory performance and (2) an interstimulus-interval-dependent deficit in auditory N₁ generation. Similar deficits are observed following systemic or local infusion of N-methyl-D-aspartate (NMDA) antagonists, supporting glutamatergic and phencyclidine/NMDA models of the disorder. Deficits in MMN generation may also be seen following focal cortical damage, especially to the dorsolateral prefrontal cortex. MMN thus provides a useful tool for investigating mechanisms underlying brain dysfunction in schizophrenia.

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Section: Role Of Attentionmentioning

confidence: 92%