ERP correlates of object recognition memory in Down syndrome: Do active and passive tasks measure the same thing?

The Arizona Cognitive Test Battery for Down Syndrome: Test-Retest Reliability and Practice Effects

“…CANTAB PAL has been used as a benchmark measure for memory deficits in several patient groups, including individuals with DS, demonstrating low levels of noncompletion, adequate test-retest reliability, and sensitivity to detect differences between individuals with DS and control participants without the confounding influence of deficits in language (Edgin, Mason, et al, 2010; Edgin, Spanò, Kawa, & Nadel, 2014; Pennington et al, 2003; Visu-Petra, Benga, & Miclea, 2007). Further, performance on this task has been shown to correlate with parent-reported memory skills and ERP assessments (Spanò & Edgin, 2016; Van Hoogmoed, Nadel, Spanò, & Edgin, 2016). …”

The use of the cambridge neuropsychological test automated battery for people born with Down syndrome and those born premature: A comparative systematic review

“…In general, Pennington et al (2003) identified hippocampal dysfunctions; the findings of Visu-Petra et al (2007) indicated a relative preservation of basic spatial short-term visual memory skills, without any particular evidence of a better visual-spatial memory in comparison with visual-object memory; Edgin et al (2011) found no significant difference between individuals with DS that had been exposed to a second language and those who had not; Breslin et al (2014) signaled that obstructive sleep apnea syndrome (OSAS) might have further impact on these individuals’ cognitive abilities; the study by del Hoyo et al (2016) suggests that genetic variants of COMTVal158Met and VNTR-DAT1 may contribute to cognitive abilities related to the prefrontal cortex, the first also being linked to behavioral phenotypes of DS; Van Hoogmoed et al (2016) did not find significant differences between active and passive event related potentials (ERP) memory measures; Spanò et al (2017) identified a robust boundary extension (BE) in this population, though some specific memory deficits emerged; Rosser et al (2018) found that congenital heart defects and gastrointestinal defects requiring surgery in the first year of life were not a predictor for cognitive or behavioral outcomes in children with DS.…”

Testing the “Boundaries” of boundary extension: Anticipatory scene representation across development and disorder

“…In individuals with DS, performance on this test demonstrates low levels of noncompletion, adequate test‐retest reliability, and sensitivity to detect differences between individuals with DS and control participants without the confounding influence of deficits in language (Edgin et al, ; Pennington et al, ; Visu‐Petra et al, ). Further, performance on this task has been shown to correlate with parent‐reported memory skills and ERP assessments (Spanò & Edgin, ; van Hoogmoed, Nadel, Spanò, & Edgin, ). Given that this measure theoretically maps onto hippocampal function, we used this test as a benchmark of memory functions that might develop or are impaired in the groups in our investigation.…”

“…These dysfunctions at the microstructural level—accompanied by evidence of hippocampal volume reduction (Pinter, Eliez, Schmitt, Capone, & Reiss, ; White, Alkire, & Haier, )—are likely to contribute to the widely‐observed phenotype in this population characterized by pervasive learning deficits in tasks tapping relational memory binding and allocentric navigation (Banta Lavenex et al, ; Edgin et al, ; Pennington, Moon, Edgin, Stredron, & Nadel, ). This phenotype has repeatedly been measured using a well‐validated assessment of memory in this population, a spatial paired associates task (CANTAB Paired Associates learning; Edgin et al, ; Pennington et al, ; Spanò & Edgin, ; Visu‐Petra, Benga, Tincas, & Miclea, ; van Hoogmoed, Nadel, Spanò, & Edgin, ).…”