ERP indices of performance monitoring and feedback processing in psychosis: A meta-analysis

Martin, Elizabeth A.; McCleery, Amanda; Moore, Michael S.; Wynn, Jonathan K.; Green, Michael F.; Horan, William P.

doi:10.1016/j.ijpsycho.2018.08.004

Cited by 38 publications

(32 citation statements)

References 83 publications

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“…Further, the suitability of reduced error-related brain activity as an endophenotype for SUD is supported by longitudinal studies showing that it predicts relapse (Luo et al ., 2013; Marhe et al ., 2013) and the initiation of tobacco use (Anokhin and Golosheykin, 2015). Besides SUD, several studies suggest that reduced ERN amplitudes are also found in schizophrenia (Martin et al ., 2018), bipolar disorder (Minzenberg et al ., 2014), and inconsistently in autism and attention-deficit/hyperactivity disorder (Manoach and Agam, 2013; Luijten et al ., 2014; Gillan et al ., 2017). This suggests that a blunted neural response to errors is common to different disorders and may reflect a shared pathophysiological mechanism.…”

Section: Discussionmentioning

confidence: 99%

Error-related brain activity as a transdiagnostic endophenotype for obsessive-compulsive disorder, anxiety and substance use disorder

et al. 2019

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BackgroundIncreased neural error-signals have been observed in obsessive-compulsive disorder (OCD), anxiety disorders, and inconsistently in depression. Reduced neural error-signals have been observed in substance use disorders (SUD). Thus, alterations in error-monitoring are proposed as a transdiagnostic endophenotype. To strengthen this notion, data from unaffected individuals with a family history for the respective disorders are needed.MethodsThe error-related negativity (ERN) as a neural indicator of error-monitoring was measured during a flanker task from 117 OCD patients, 50 unaffected first-degree relatives of OCD patients, and 130 healthy comparison participants. Family history information indicated, that 76 healthy controls were free of a family history for psychopathology, whereas the remaining had first-degree relatives with depression (n = 28), anxiety (n = 27), and/or SUD (n = 27).ResultsIncreased ERN amplitudes were found in OCD patients and unaffected first-degree relatives of OCD patients. In addition, unaffected first-degree relatives of individuals with anxiety disorders were also characterized by increased ERN amplitudes, whereas relatives of individuals with SUD showed reduced amplitudes.ConclusionsAlterations in neural error-signals in unaffected first-degree relatives with a family history of OCD, anxiety, or SUD support the utility of the ERN as a transdiagnostic endophenotype. Reduced neural error-signals may indicate vulnerability for under-controlled behavior and risk for substance use, whereas a harm- or error-avoidant response style and vulnerability for OCD and anxiety appears to be associated with increased ERN. This adds to findings suggesting a common neurobiological substrate across psychiatric disorders involving the anterior cingulate cortex and deficits in cognitive control.

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Section: Discussionmentioning

confidence: 99%

Error-related brain activity as a transdiagnostic endophenotype for obsessive-compulsive disorder, anxiety and substance use disorder

et al. 2019

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“…A relatively new marker is error‐related negativity, a key measure of early performance monitoring associated with function of the anterior cingulate 235 . This measure is blunted across psychotic disorders as well as in schizotypal personality disorder and clinical high risk groups 236 . This blunting appears to be specific to detachment rather than thought disorder 237,238 .…”

Section: Validity Evidencementioning

confidence: 92%

Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): I. Psychosis superspectrum

et al. 2020

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The Hierarchical Taxonomy of Psychopathology (HiTOP) is a scientific effort to address shortcomings of traditional mental disorder diagnoses, which suffer from arbitrary boundaries between psychopathology and normality, frequent disorder co‐occurrence, heterogeneity within disorders, and diagnostic instability. This paper synthesizes evidence on the validity and utility of the thought disorder and detachment spectra of HiTOP. These spectra are composed of symptoms and maladaptive traits currently subsumed within schizophrenia, other psychotic disorders, and schizotypal, paranoid and schizoid personality disorders. Thought disorder ranges from normal reality testing, to maladaptive trait psychoticism, to hallucinations and delusions. Detachment ranges from introversion, to maladaptive detachment, to blunted affect and avolition. Extensive evidence supports the validity of thought disorder and detachment spectra, as each spectrum reflects common genetics, environmental risk factors, childhood antecedents, cognitive abnormalities, neural alterations, biomarkers, and treatment response. Some of these characteristics are specific to one spectrum and others are shared, suggesting the existence of an overarching psychosis superspectrum. Further research is needed to extend this model, such as clarifying whether mania and dissociation belong to thought disorder, and explicating processes that drive development of the spectra and their subdimensions. Compared to traditional diagnoses, the thought disorder and detachment spectra demonstrated substantially improved utility: greater reliability, larger explanatory and predictive power, and higher acceptability to clinicians. Validated measures are available to implement the system in practice. The more informative, reliable and valid characterization of psychosis‐related psychopathology offered by HiTOP can make diagnosis more useful for research and clinical care.

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“…Given that patients with schizophrenia have impaired processing of negative feedback [44], which is detectable in the very early trials of the Wisconsin Card Sort Test [45], we looked at the responses of the rats to positive and negative feedback in the acquisition stages (SD, ID and ED).…”

Section: Acquisition Stagesmentioning

confidence: 99%

Exacerbation of the credit assignment problem in rats with lesions of the medial prefrontal cortex is revealed by Bayesian analysis of behavior in the pre-solution period of learning

Wang

Tait

Brown

et al. 2019

Behavioural Brain Research

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ERP indices of performance monitoring and feedback processing in psychosis: A meta-analysis

Cited by 38 publications

References 83 publications

Error-related brain activity as a transdiagnostic endophenotype for obsessive-compulsive disorder, anxiety and substance use disorder

Error-related brain activity as a transdiagnostic endophenotype for obsessive-compulsive disorder, anxiety and substance use disorder

Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): I. Psychosis superspectrum

Exacerbation of the credit assignment problem in rats with lesions of the medial prefrontal cortex is revealed by Bayesian analysis of behavior in the pre-solution period of learning

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