ERPs and Psychopathology

Abstract

We have briefly covered important issues and considerations in four topic areas likely to be of use to the ERP researcher who is also interested in biological psychiatry. We cannot ignore diagnosis because of its basic role in the field of psychiatry. Although there are reliability problems, especially in the field of psychiatric diagnosis, ERPs may help in the painstaking task of validating diagnosis based on behavioral observation. In addition, the ERP researcher can use diagnosis to obtain potentially more homogeneous samples of patients so as to reduce between-subject error variance in studies. We have considered research areas like PET scan and CT scan which provide data of more anatomical precision than ERPs for deep neurological sites. While the potential may be there, it is essentially unrealized as yet. Finally, neurochemistry and psychopharmacology seem to be the areas most likely to bear fruit in the immediate future. If this potential is to be realized, it is necessary to formulate new questions and a new methodology to handle these questions. An important question, for example, is whether a biological profile is a more useful criterion than a behavioral profile for predicting response to pharmacological intervention. In biological psychiatry, this question is a human suffering issue of considerable importance.

Cognitive event-related potential correlates of schizophrenia.

“…Any review of the literature relating endogenous ERPs to schizophrenia almost by necessity must point out the many problems involved in the psychiatric diagnosis of schizophrenia (for reviews see Donchin & Bashore, in press, and Roemer & Connolly's section of Tueting et al, 1984). These problems, mostly centering on the often poor agreement between the different diagnostic systems that have been developed, have led some researchers to call for adoption of a psychophysiological as opposed to a clinical paradigm for the investigation of the ERPs of schizophrenics (Callaway, 1979; Donchin & Bashore, in press).…”