Errata: In vivo assessment of human burn scars through automated quantification of vascularity using optical coherence tomography

Liew, Yih Miin; McLaughlin, Robert A.; Gong, Peijun; Wood, Fiona; Sampson, David D.

doi:10.1117/1.jbo.18.6.069801

Cited by 24 publications

(40 citation statements)

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“…2. We calculated the speckle decorrelation of co-located B-scans acquired at sequential time points, t and ' t , using a previously published method [11,20] where ( , , , ) i x y z t is the amplitude of the complex OCT signal at lateral location (x, y), depth location z, and time point t ; and the speckle decorrelation ( , , ) D x y z is calculated in a widow defined by M N × pixels in the cross-sectional (x-z) plane. We show both an OCT B-scan in Fig.…”

Section: Characteristic Optical Signature Of Lymphatic Vesselsmentioning

confidence: 99%

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In vivo label-free lymphangiography of cutaneous lymphatic vessels in human burn scars using optical coherence tomography

Gong

Es'haghian

Harms

et al. 2016

Biomed. Opt. Express

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Abstract:We present an automated, label-free method for lymphangiography of cutaneous lymphatic vessels in humans in vivo using optical coherence tomography (OCT). This method corrects for the variation in OCT signal due to the confocal function and sensitivity fall-off of a spectral-domain OCT system and utilizes a single-scattering model to compensate for Ascan signal attenuation to enable reliable thresholding of lymphatic vessels. A segmentjoining algorithm is then incorporated into the method to mitigate partial-volume effects with small vessels. The lymphatic vessel images are augmented with images of the blood vessel network, acquired from the speckle decorrelation with additional weighting to differentiate blood vessels from the observed high decorrelation in lymphatic vessels. We demonstrate the method with longitudinal scans of human burn scar patients undergoing ablative fractional laser treatment, showing the visualization of the cutaneous lymphatic and blood vessel networks. Dermatol. Symp. Proc. 5(1), 14-19 (2000). 33. C. Blatter, E. F. J. Meijer, A. S. Nam, D. Jones, B. E. Bouma, T. P. Padera, and B. J. Vakoc, "In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography," Sci. Rep. 6, 29035 (2016).

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Section: Characteristic Optical Signature Of Lymphatic Vesselsmentioning

confidence: 99%

“…OCT uses coherent, near-infrared light to acquire high-resolution (1-20 μm) volumetric scans of tissue microstructure. Extensions of OCT have also been developed to image other aspects of the circulatory system, specifically the blood microvasculature [7,9], such as in skin tissue [10][11][12], typically to a depth of 0.5-1 mm.…”

Section: Introductionmentioning

confidence: 99%

In vivo label-free lymphangiography of cutaneous lymphatic vessels in human burn scars using optical coherence tomography

Gong

Es'haghian

Harms

et al. 2016

Biomed. Opt. Express

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“…A clinical assessment of vascularity in burn scars of human patients in vivo has been demonstrated by using speckle decorrelation OCT. 94 Their quantitative vascular parameters showed increased vascular density and enlarged vessel diameter in scar tissue compared with normal skin. Several vascular contrast OCT methods have been developed.…”

Section: Vascular Mapping and Perfusion Measurements With Optical Cohmentioning

confidence: 99%

Review of near-infrared methods for wound assessment

Sowa

Kuo²,

et al. 2016

J. Biomed. Opt

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Vous avez des questions? Nous pouvons vous aider. Pour communiquer directement avec un auteur, consultez la première page de la revue dans laquelle son article a été publié afin de trouver ses coordonnées. Si vous n'arrivez pas à les repérer, communiquez avec nous à PublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. Questions? Contact the NRC Publications Archive team atPublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. If you wish to email the authors directly, please see the first page of the publication for their contact information. NRC Publications Archive Archives des publications du CNRCThis publication could be one of several versions: author's original, accepted manuscript or the publisher's version. / La version de cette publication peut être l'une des suivantes : la version prépublication de l'auteur, la version acceptée du manuscrit ou la version de l'éditeur. NRC Publications Record / Notice d'Archives des publications de CNRC:http://nparc.cisti-icist.nrc-cnrc.gc.ca/eng/view/object/?id=f622d2fd-d6fd-477b-9502-e09dd5a4b2d2 http://nparc.cisti-icist.nrc-cnrc.gc.ca/fra/voir/objet/?id=f622d2fd-d6fd-477b-9502-e09dd5a4b2d2Review of near-infrared methods for wound assessment Abstract. Wound management is a challenging and costly problem that is growing in importance as people are living longer. Instrumental methods are increasingly being relied upon to provide objective measures of wound assessment to help guide management. Technologies that employ near-infrared (NIR) light form a prominent contingent among the existing and emerging technologies. We review some of these technologies. Some are already established, such as indocyanine green fluorescence angiography, while we also speculate on others that have the potential to be clinically relevant to wound monitoring and assessment. These various NIR-based technologies address clinical wound management needs along the entire healing trajectory of a wound.

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“…Furthermore, dermal birefringence, which can be utilized to diagnose sun damage [31] or determine burn depth [32], can be visualized and quantitatively evaluated using polarizationsensitive optical coherence tomography (PS-OCT). Moreover, OCT was used to assess human burn scars through quantification of the vascularity [33]. Furthermore, Yasuno et al…”

Section: Introductionmentioning

confidence: 99%

Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography

Tsai¹,

Yang²,

Shen³

et al. 2013

Biomed. Opt. Express

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Abstract:Fractional photothermolysis induced by non-ablative fractional lasers (NAFLs) or ablative fractional lasers (AFLs) can remodel the skin, regenerate collagen, and remove tumor tissue. However, fractional laser treatments may result in severe side effects, and multiple treatments are required to achieve the expected outcome. Thus, the treatment outcome and downtime after fractional laser treatments are key issues to determine the following treatment strategy. In this study, an optical coherence tomography (OCT) system was implemented for in vivo studies of wound healing after NAFL and AFL treatments. According to the OCT scanning results, the laser-induced photothermolysis including volatilization and coagulation could be morphologically identified. To continue monitoring the wound healing process, the treated regions were scanned with OCT at different time points, and the en-face images at various tissue depths were extracted from three-dimensional OCT images. Furthermore, to quantitatively evaluate the morphological changes at different tissue depths during wound healing, an algorithm was developed to distinguish the backscattering properties of untreated and treated tissues. The results showed that the coagulation damage induced by the NAFLs could be rapidly healed in 6 days. In contrast, the tissue volatilization induced by AFLs required a longer recovery time of 14 days. In conclusion, this study establishes the feasibility of this methodology as a means of clinically monitoring treatment outcomes and wound healing after fractional laser treatments. References and links 1. T. S. Alster and S. Garg, "Treatment of facial rhytides with a high-energy pulsed carbon dioxide laser," Plast. ©2013 Optical Society of AmericaReconstr. Surg. 98(5), 791-794 (1996). 2. C. B. Zachary, "Modulating the Er:YAG laser," Lasers Surg. Med. 26(2), 223-226 (2000).

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Errata: In vivo assessment of human burn scars through automated quantification of vascularity using optical coherence tomography

Cited by 24 publications

References 0 publications

In vivo label-free lymphangiography of cutaneous lymphatic vessels in human burn scars using optical coherence tomography

In vivo label-free lymphangiography of cutaneous lymphatic vessels in human burn scars using optical coherence tomography

Review of near-infrared methods for wound assessment

Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography

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