Erratum: Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function

Serini, Guldo; Valdembri, Donatella; Zanivan, Sara; Morterra, Giulia; Burkhardt, Constanze; Caccavarl, Francesca; Zammataro, Luca; Primo, Luca; Tamagnone, Luca; Logan, Malcolm; Tessier‐Lavigne, Marc; Taniguchl, Masahiko; Püschel, Andreas W.; Bussolino, Federico

doi:10.1038/nature01946

Cited by 2 publications

(5 citation statements)

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“…Defects in endothelial guidance and vessel maturation after this time point could therefore have culminated in the severely reduced capillary density, centralized placement of capillaries within septa, and reduced capillary-pneumocyte membrane adhesion observed in Nrp1 SemaϪ neonates. It is not clear whether the presenting phenotype resulted from the absence of unique Sema3-Nrp1 signaling mechanisms, 12 unregulated Vegf-Nrp1 binding, 47 or through alterations in the formation of Nrp1-Vegfr-2 complexes. 15 One important limitation of the present study is the difficulty in isolating the precise mechanism behind the dysmorphic vasculature of Nrp1 SemaϪ mice.…”

Section: Discussionmentioning

confidence: 99%

“…19,31 We were particularly interested in the expression pattern of SEMA3C because, among other SEMA3 proteins, it is proangiogenic and is directly implicated in vascular morphogenesis. 12,18,32,33 qPCR and immunocytochemistry on isolated late-gestation lung mesenchymal and epithelial cells demonstrated enrichments in Nrp1 and Sema3c mRNA, respectively, suggesting Sema3c-Nrp1 signaling interactions between the epithelium and endothelium during the formation of the alveolar-capillary interface (see Supplemental Figure S1 at http://ajp.amjpathol.org). In murine fetal lung sections, Sema3c protein was prominently expressed throughout the length of the branching airway epithelium at all stages of development (Figure 1, B-E).…”

Section: Sema3 Ligand and Receptor Expression Increases During Fetal Lung Developmentmentioning

confidence: 98%

“…Because class 3 semaphorins have been proposed as mediators of vascular development, 12,14 we further assessed the microvasculature in Nrp1 SemaϪ mutants. Morphometric analyses revealed significantly reduced numbers and increased dilation of capillaries within the alveolar walls in Nrp1 SemaϪ mice relative to controls (Figure 6, A and B).…”

Section: Impaired Pulmonary Angiogenesis In Nrp1 Semaϫ Micementioning

confidence: 99%

“…Indeed, recent studies have indicated essential roles for SEMA3 in both normal and pathological vascular development, many of which mirror or directly oppose the known functions of VEGF. 12,20,21 In contrast, other researchers have maintained that SEMA3-NRP1 interactions are uninvolved in vascular development. 19,22 In the present study, we determined the role of Sema3-Nrp1 signaling during fetal pulmonary development in a mouse model.…”

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confidence: 95%

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Loss of Semaphorin-Neuropilin-1 Signaling Causes Dysmorphic Vascularization Reminiscent of Alveolar Capillary Dysplasia

Joza

Wang

Fox

et al. 2012

The American Journal of Pathology

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Respiratory diseases of the newborn can arise from the disruption of essential angiogenic pathways. Neuropilin-1 (NRP1), which is a critical receptor implicated in systemic vascular growth and remodeling, binds two distinct ligand families: vascular endothelial growth factor (VEGF) and class 3 semaphorins (SEMA3). Although the function of VEGF-NRP1 interactions in vascular development is well described, the importance of SEMA3-NRP1 signaling in systemic or pulmonary vascular morphogenesis is debated. We sought to characterize the effect of deficient SEMA3-NRP1 signaling on fetal pulmonary vascular development in a mouse model. Temporospatial expression of Nrp1 and Sema3 mRNA and protein during murine fetal lung development was investigated, and the development of the pulmonary vasculature in transgenic mice deficient in Sema3-Nrp1 signaling was examined by histology, immunostaining, and electron microscopy. Loss of Sema3-Nrp1 signaling resulted in acute respiratory distress and high neonatal mortality. Pathohistological examination of mutants revealed immature and atelectatic regions in the lung, severely reduced capillary density, thickened alveolar septa containing centrally located dilated capillaries, hypertensive changes in arteriolar walls, anomalous and misaligned pulmonary veins, and reduced pulmonary surfactant secretion. Notably, many features are reminiscent of the fatal pulmonary disorder alveolar capillary dysplasia. These findings indicate a critical role for Sema3-Nrp1 signaling in fetal pulmonary development, which may have clinical relevance for treatment of various neonatal respiratory disorders, including alveolar capillary dysplasia.

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Section: Discussionmentioning

confidence: 99%

Section: Sema3 Ligand and Receptor Expression Increases During Fetal Lung Developmentmentioning

confidence: 98%

Section: Impaired Pulmonary Angiogenesis In Nrp1 Semaϫ Micementioning

confidence: 99%

mentioning

confidence: 95%

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Loss of Semaphorin-Neuropilin-1 Signaling Causes Dysmorphic Vascularization Reminiscent of Alveolar Capillary Dysplasia

Joza

Wang

Fox

et al. 2012

The American Journal of Pathology

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“…Recent evidence suggests that semaphorins are constitutively expressed in the postnatal brain and may be involved in neuronal plasticity and nervous system physiology (95). Semaphorins are also expressed in endothelial cells during vascular development (96). Interestingly, as elaborated in the previous sections, semaphorins act as guidance factors during the migration of GnRH neurons (14, 40, 60, 65, 66), which retain a high degree of plasticity in the mature brain (97).…”

Section: Semaphorins and The Plasticity Of Adult Hormone Systemsmentioning

confidence: 99%

Semaphorin Signaling in the Development and Function of the Gonadotropin Hormone-Releasing Hormone System

Messina¹,

Giacobini²

2013

Front. Endocrinol.

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The semaphorin proteins are among the best-studied families of guidance cues, contributing to morphogenesis and homeostasis in a wide range of tissue types. The major semaphorin receptors are plexins and neuropilins, however other receptors and co-receptors are capable to mediate signaling by semaphorins. These guidance proteins were originally identified as growth cone “collapsing factors” or as inhibitory signals, crucial for nervous system development. Since those seminal discoveries, the list of functions of semaphorins has rapidly grown. Over the past few years, a growing body of data indicates that semaphorins are involved in the regulation of the immune and vascular systems, in tumor growth/cancer cell metastasis and in neural circuit formation. Recently there has been increasing emphasis on research to determine the potential influence of semaphorins on the development and homeostasis of hormone systems and how circulating reproductive hormones regulate their expression and functions. Here, we focus on the emerging role of semaphorins in the development, differentiation and plasticity of unique neurons that secrete gonadotropin-releasing hormone (GnRH), which are essential for the acquisition and maintenance of reproductive competence in all vertebrates. Genetic evidence is also provided showing that insufficient semaphorin signaling contributes to some forms of reproductive disorders in humans, characterized by the reduction or failure of sexual competence. Finally, we will review some studies with the goal of highlighting how the expression of semaphorins and their receptors might be regulated by gonadal hormones in physiological and pathological conditions.

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Erratum: Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function

Abstract: In Figs 3c, g and 4c, g of this Article, the colour keys are incorrect. The light grey and white boxes were interchanged. The description of the results in the text is correct. A letters to nature

Cited by 2 publications

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Loss of Semaphorin-Neuropilin-1 Signaling Causes Dysmorphic Vascularization Reminiscent of Alveolar Capillary Dysplasia

Loss of Semaphorin-Neuropilin-1 Signaling Causes Dysmorphic Vascularization Reminiscent of Alveolar Capillary Dysplasia

Semaphorin Signaling in the Development and Function of the Gonadotropin Hormone-Releasing Hormone System

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