Erratum: Corrigendum: Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells

Li, Weida; Cavelti-Weder, Claudia; Zhang, Yinying; Clement, Kendell; Donovan, Scott; González, Gabriel; Jing-ci, Zhu; Stemann, Marianne; Xu, Ke; Hashimoto, Tatsu; Yamada, Takatsugu; Nakanishi, Mio; Zhang, Yuemei; Zeng, Samuel; Gifford, David K.; Meissner, Alexander; Weir, Gordon C.; Zhou, Qiao

doi:10.1038/nbt0815-882a

Nat Biotechnol

2015

DOI: 10.1038/nbt0815-882a

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Erratum: Corrigendum: Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells

Weida Li¹,

Claudia Cavelti-Weder²,

Yinying Zhang³

et al.

Abstract: In the version of this article initially published, Yingying Zhang's name was spelled Yinying Zhang. The error has been corrected in the HTML and PDF versions of the article.

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Efficient generation of pancreatic β-like cells from the mouse gallbladder

et al. 2016

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Direct reprogramming is a promising approach for the replacement of β cells in diabetes. Reprogramming of cells originating from the endodermal lineage, such as acinar cells in the pancreas, liver cells and gallbladder cells has been of particular interest because of their developmental proximity to β cells. Our previous work showed that mouse gallbladder epithelium can be partially reprogrammed in vitro to generate islet-like cells (rGBC1). Here, the reprogramming protocol was substantially improved, yielding cells (rGBC2) closer to functional β cells than the 1st generation method with higher conversion efficiency and insulin expression. In addition to insulin synthesis and processing, rGBC2 presented many hallmark features of β cells, including insulin secretion in response to high glucose stimulation. Gene expression analysis indicated that rGBC2 clustered closer with β cells and had a metabolic gene expression profile resembling neonatal β cells. When transplanted into immune-deficient animals, rGBC2 were stable for at least 5months and further matured in vivo. Taken together, this approach provides further understanding of endodermal lineage conversion and potential for development of cell replacement therapy for type 1 diabetes patients.

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Efficient generation of pancreatic β-like cells from the mouse gallbladder

et al. 2016

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<i>In vivo</i> direct reprogramming of liver cells to insulin producing cells by virus-free overexpression of defined factors

Yang

Ren

et al. 2017

Endocr J

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Erratum: Corrigendum: Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells

Abstract: In the version of this article initially published, Yingying Zhang's name was spelled Yinying Zhang. The error has been corrected in the HTML and PDF versions of the article.

Cited by 2 publications

References 1 publication

Efficient generation of pancreatic β-like cells from the mouse gallbladder

Efficient generation of pancreatic β-like cells from the mouse gallbladder

<i>In vivo</i> direct reprogramming of liver cells to insulin producing cells by virus-free overexpression of defined factors

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