Erratum: Corrigendum: Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract

Liu, Yaobo; Shi, Jun; Lu, Chin-Chun; Wang, Zheng-Bei; Lyuksyutova, Anna I; Song, Xue-Jun; Zou, Yimin

doi:10.1038/nn0106-147b

Cited by 3 publications

(3 citation statements)

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“…Another important pathway activated by drugs of addiction involves the second messenger Ca 2+ , calmodulin, and Ca 2+ /Calmodulin-dependent-kinases. Activation of this pathway is essential for various types of learning (Giese et al, 1998; Irvine et al, 2006; Easton et al, 2013b) as well as for several drug-related behaviors (Licata and Pierce, 2003; Liu et al, 2006; Anderson et al, 2008; Bilbao et al, 2008; Easton et al, 2013a). A series of functional studies showed that antisense oligodeoxynucleotides for the immediate early gene, Zif268, in the basolateral amygdala could disrupt different memories for cocaine and heroin (Lee et al, 2005, 2006; Hellemans et al, 2006).…”

Section: Acute Physiological Effects Of Drugs In Memory Systems Of Thmentioning

confidence: 99%

Episodic Memories and Their Relevance for Psychoactive Drug Use and Addiction

Müller¹

2013

Front. Behav. Neurosci.

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The majority of adult people in western societies regularly consume psychoactive drugs. While this consumption is integrated in everyday life activities and controlled in most consumers, it may escalate and result in drug addiction. Non-addicted drug use requires the systematic establishment of highly organized behaviors, such as drug-seeking and -taking. While a significant role for classical and instrumental learning processes is well established in drug use and abuse, declarative drug memories have largely been neglected in research. Episodic memories are an important part of the declarative memories. Here a role of episodic drug memories in the establishment of non-addicted drug use and its transition to addiction is suggested. In relation to psychoactive drug consumption, episodic drug memories are formed when a person prepares for consumption, when the drug is consumed and, most important, when acute effects, withdrawal, craving, and relapse are experienced. Episodic drug memories are one-trial memories with emotional components that can be much stronger than “normal” episodic memories. Their establishment coincides with drug-induced neuronal activation and plasticity. These memories may be highly extinction resistant and influence psychoactive drug consumption, in particular during initial establishment and at the transition to “drug instrumentalization.” In that, understanding how addictive drugs interact with episodic memory circuits in the brain may provide crucial information for how drug use and addiction are established.

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Section: Acute Physiological Effects Of Drugs In Memory Systems Of Thmentioning

confidence: 99%

Episodic Memories and Their Relevance for Psychoactive Drug Use and Addiction

Müller¹

2013

Front. Behav. Neurosci.

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“…Interestingly, Kash et al (2009) recently found a significant decrease in the total levels of CaMKIIα in the central extended amygdala after ethanol exposure in mice. CaMKIIα expression enhances the extent of desensitization of NR2B-containing NMDA receptors in heterologous cells (Sessoms-Sikes et al, 2005) and regulates ethanol sensitivity of BK channels (Liu et al, 2006a), which suggested the possibility that reduced levels of CaMKIIα could be acting in a general fashion to modulate the ethanol sensitivity of channels in the extended amygdala (Kash et al, 2009). Coincidently, another miRNA, miR-9, also implicated in controlling the activity of the TLR signaling pathway through direct targeting of the NFKB1 gene in human monocytes and neutrophils (Bazzoni et al, 2009; O’Neill et al, 2011), was demonstrated to regulate ethanol sensitivity of BK channels by selectively destabilizing splice variants that contained miR-9 recognition elements, therefore making the BK channels less sensitive to alcohol (Pietrzykowski et al, 2008).…”

Section: Human Alcohol-responsive Mirnas and Neuroinflammationmentioning

confidence: 99%

Understanding Alcoholism Through microRNA Signatures in Brains of Human Alcoholics

Nunez¹,

Mayfield²

2012

Front. Gene.

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Advances in the fields of genomics and genetics in the last decade have identified a large number of genes that can potentially influence alcohol-drinking behavior in humans as well as animal models. Consequently, the task of identifying efficient molecular targets that could be used to develop effective therapeutics against the disease has become increasingly daunting. One of the reasons for this is the fact that each of the many alcohol-responsive genes only contributes a small effect to the overall mechanism and disease phenotype, as is characteristic of complex traits. Current research trends are hence shifting toward the analysis of gene networks rather than emphasizing individual genes. The discovery of microRNAs and their mechanisms of action on regulation of transcript level and protein translation have made evident the utility of these small non-coding RNA molecules that act as central coordinators of multiple cross-communicating cellular pathways. Cells exploit the fact that a single microRNA can target hundreds of mRNA transcripts and that a single mRNA transcript can be simultaneously targeted by distinct microRNAs, to ensure fine-tuned and/or redundant control over a large number of cellular functions. By the same token, we can use these properties of microRNAs to develop novel, targeted strategies to combat complex disorders. In this review, we will focus on recent discoveries of microRNA signatures in brain of human alcoholics supporting the hypothesis that changes in gene expression and regulation by microRNAs are responsible for long-term neuroadaptations occurring during development of alcoholism. We also discuss insights into the potential modulation of epigenetic regulators by a subset of microRNAs. Taken together, microRNA activity may be controlling many of the cellular mechanisms already known to be involved in the development of alcoholism, and suggests potential targets for the development of novel therapeutic interventions.

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“…(41) The critical role of Ctip2 as a necessary factor in controlling CSMN axonal connectivity is further supported by the finding that loss of Satb2, a gene important for maintaining callosal neuron projections, causes upper layer neurons to express CTIP2 and, consequently, to extend axons through the internal capsule. (66,68) Ctip2 likely acts earlier than genes involved in controlling axon guidance to targets in the brainstem and spinal cord, (45,(75)(76)(77) and genes, including the transcription factor Otx1, (78) that refine the postnatal pruning of axon collaterals of different classes of subcerebral PN.…”

Section: Molecular Definition and Development Of Corticospinal Motor Neuronsmentioning

confidence: 99%

Untangling the cortex: Advances in understanding specification and differentiation of corticospinal motor neurons

Shoemaker

Arlotta

2010

BioEssays

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The mature cerebral cortex contains a staggering variety of projection neuron subtypes, and a number of complementary studies have recently begun to define their identity and embryonic origin. Among the different types of cortical projection neurons, subcerebral projection neurons, including corticospinal motor neurons (CSMN), have been extensively studied and some of the molecular controls over their differentiation have been elucidated. Here, we first provide an overview of the approaches used to purify and molecularly profile neuronal populations of the neocortex and, more broadly, of the central nervous system (CNS). Next, we specifically review recent progress in understanding the genes that define and control development of the CSMN population. Finally, we briefly discuss the relevance of this work to current questions regarding the mechanisms of the establishment of projection neuron subtype identity in the neocortex and its implications to direct the differentiation of CSMN for therapeutic benefit.

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Erratum: Corrigendum: Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract

Cited by 3 publications

References 1 publication

Episodic Memories and Their Relevance for Psychoactive Drug Use and Addiction

Episodic Memories and Their Relevance for Psychoactive Drug Use and Addiction

Understanding Alcoholism Through microRNA Signatures in Brains of Human Alcoholics

Untangling the cortex: Advances in understanding specification and differentiation of corticospinal motor neurons

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