Erratum for Algburi et al., Control of Biofilm Formation: Antibiotics and Beyond

Algburi, Ammar; Comito, Nicole; Kashtanov, Dimitri; Dicks, Leon M. T.; Chikindas, Michael L.

doi:10.1128/aem.00165-17

Cited by 29 publications

(12 citation statements)

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“…However, heavy metals and large amounts of proteases are not suitable for the control of biofilms formed on meat. Other studies have applied glycosidases, proteases and DNases to and their combinations to degrade the extracellular matrix 64 . The effectiveness of these enzymes can depend on environmental conditions and their effect on meat is unknown.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the biofilm matrix composition of psychrotrophic, meat spoilage pseudomonads

Wickramasinghe

Hlaing

Ravensdale

et al. 2020

Sci Rep

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Psychrotrophic Pseudomonas species are the key spoilage bacteria of aerobically stored chilled meat. These organisms readily form biofilms on meat under refrigerated conditions leading to consumer rejection and associated economic losses. Limited information is available on the matrix composition of the biofilms formed by these bacteria. We quantified and characterized the main components of the matrix of mono-species biofilms of selected Pseudomonas fragi and Pseudomonas lundensis strains using chemical analysis and Raman spectroscopy. The biofilms were grown at 10 °C and 25 °C on nitro-cellulose membranes placed on surface sterilized beef cuts. Extra-cellular polymeric substances of the matrix were extracted in soluble and bound forms and were chemically assessed for total carbohydrates, proteins and extra-cellular DNA. Both Pseudomonas species showed a significant increase in total carbohydrates and total proteins when grown at 10 °C as compared to 25 °C. Extra-cellular DNA did not show a strong correlation with growth temperature. Raman spectra were obtained from planktonic bacteria and membrane grown biofilms at 10 °C and 25 °C. Higher levels of guanine were detected in planktonic cells as compared to biofilm cells. This study suggests that psychrotrophic Pseudomonas species may respond to cold stress by increasing extra-cellular polymer secretions.

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Section: Discussionmentioning

confidence: 99%

Characterization of the biofilm matrix composition of psychrotrophic, meat spoilage pseudomonads

Wickramasinghe

Hlaing

Ravensdale

et al. 2020

Sci Rep

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“…The latter mainly includes a range of substances such as polysaccharides, proteins, nucleic acids, and lipids, forming a dense physical barrier that renders, along with other mechanisms, biofilm cells much more resistant to antibacterial drugs than their non-adherent planktonic cells 8 , 9 . In recent years, much attention has been directed to uncovering new approaches including combination therapy against biofilm infections 10 , 11 .…”

Section: Introductionmentioning

confidence: 99%

“…Control of bacterial biofilm formation is considered as one major strategy against bacterial infections, and thus efforts have been made to identify effective inhibitors that go beyond conventional antibiotics for their ability to disrupt biofilm formation 10 . For example, it has been reported that three chemical substances, zinc lactate, stannous fluoride and furanone, and two antibiotics, azithromycin and rifampicin, can inhibit bacterial biofilm formation, but cannot effectively control the infection caused by biofilm-forming bacteria 12 – 17 .…”

Section: Introductionmentioning

confidence: 99%

In vitro activity of biofilm inhibitors in combination with antibacterial drugs against extensively drug-resistant Acinetobacter baumannii

Qin

Lin

Ling

2020

Sci Rep

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Acinetobacter baumannii is a common pathogen of nosocomial infection, and its ability to form biofilms further contributes to its virulence and multidrug resistance, posing a great threat to global public health. In this study, we investigated the inhibitory effects of five biofilm inhibitors (BFIs) (zinc lactate, stannous fluoride, furanone, azithromycin, and rifampicin) on biofilm formation of nine extensively drug-resistant A. baumannii (XDRAB), and assessed the synergistic antibacterial effects of these BFIs when combined with one of four conventional anti-A. baumannii antibiotics (imipenem, meropenem, tigecycline, and polymyxin B). Each of the five BFIs tested was found to be able to significantly inhibit biofilm formation of all the clinical isolates tested under sub-minimal inhibitory concentrations. Then, we observed synergistic effects (in 22%, 56% and 11% of the isolates) and additive effects (56%, 44% and 44%) when zinc lactate, stannous fluoride and furanone were combined with tigecycline, respectively. When zinc lactate and stannous fluoride were each used with a carbapenem (imipenem or meropenem), in 33% and 56–67% of the isolates, they showed synergistic and additive effects, respectively. Additivity in > 50% of the isolates was detected when rifampicin was combined with imipenem, meropenem, tigecycline, or polymyxin B; and a 100% additivity was noted with azithromycin-polymyxin B combination. However, antagonism and indifference were noted for polymyxin B in its combination with zinc lactate and stannous fluoride, respectively. In conclusion, five BFIs in combination with four antibacterial drugs showed different degrees of in vitro synergistic and additive antibacterial effects against XDRAB.

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“…By adapting themselves with these challenges, the bacterial species often acquire resistance against the conventional drugs. [38] Thus, it's a tough challenge to the scientific community to overcome the chronic bacterial infections threat concerning biofilm, posed by the bacteria and to search alternative treatments, which can eradicate biofilm efficiently. P. aeruginosa is a well-known gram-negative bacteria causing 70 to 80 % nosocomial infections in patients, suffering from cystic fibrosis, urinary tract infections, upper respiratory tract infection, and patients with organ transplants.…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Iron Nanoparticles for Investigation of Biofilm Inhibition Property

et al. 2020

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Green metal nanoparticles (NPs) have emerged as efficient biofilm inhibitors. Citrus macroptera (CM) fruit extract mediated iron (Fe) NPs, i. e., CM-FeNPs were thus synthesized for studying biofilm inhibition property. The shape (spherical), size (12 nm), and crystallinity (α-Fe 0 bcc) of the CM-FeNPs were confirmed by studying mainly Transmission Electron microscopy (TEM) and X-ray Diffractometer (X-RD) tools. The particles inhibit biofilm growth of a bacteria Pseudomonas aeruginosa (P. aeruginosa) by inhibiting the functions of extracellular polymeric substances (EPS) and virulence factors to ∼ 80 %. Scanning Electron microscopy (SEM) images of the bacteria in presence of the CM-FeNPs (4600 nM) in combination with azithromycin (AZI) evidence the inhibition of biofilm growth > 80 %. Molecular docking studies support experimental findings and result significant negative binding energies (e. g., isoplatydesmine/LasR: À 8.25 kcal/mole, isoplatydesmine/MvfR: À 7.56 kcal/mole) from bioactive molecules/biofilm proteins interactions. Thus, CM-FeNPs could be considered as potential biofilm inhibitors, and as an alternative to antibiotic drugs.

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Erratum for Algburi et al., Control of Biofilm Formation: Antibiotics and Beyond

Cited by 29 publications

References 0 publications

Characterization of the biofilm matrix composition of psychrotrophic, meat spoilage pseudomonads

Characterization of the biofilm matrix composition of psychrotrophic, meat spoilage pseudomonads

In vitro activity of biofilm inhibitors in combination with antibacterial drugs against extensively drug-resistant Acinetobacter baumannii

Green Synthesis of Iron Nanoparticles for Investigation of Biofilm Inhibition Property

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