Erratum for Nagesh et al., Phytochemical analysis and docking study of compounds present in a polyherbal preparation used in the treatment of dermatophytosis

Nagesh, Simhadri Vsdna; Muniappan, M; Kannan, I

doi:10.18502/cmm.v4i1.33

Cited by 3 publications

(1 citation statement)

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“…Notably, leaf and bark were used in the treatment of gingivitis, periodontitis, sores, boils, enlarged spleen and malarial fever during childbirth, measles, smallpox, head scald, as well as cutaneous affections [13]. Moreover, seed oil from neem and essential oils of both leaves and bark possessed the potentialities of curing many ailments notably; Mycobacterium and Plasmodium [14]. Neem oil was used as contraceptive (Vaginal infections) and mosquito repellent due to the fact that, nimbin, nimbinin were found and nimbidin inclusive [13].…”

Section: Medicinal Values Of Neemmentioning

confidence: 99%

Noteworthy Threatened Plant Species in the Sahel Region, Nigeria

Salihu¹,

Go²

2021

Endangered Plants

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The loss of biodiversity in Nigeria is intensifying distressingly, which happened to be more prominent in some states across northwestern as well as north eastern geopolitical regions of Nigeria and was threatened by the confrontational effect of desertification. The Sahel region and some part of the savannah region bordered which faced the menace of drought and desertification which lead to so many factors like soil erosion, distraction of the ecosystem entirely. Moreover, the plants destroyed were mostly aromatic plants which served as medicines in curing many ailments and diseases contributed to the economic status of the communities found in the Sahel. The plants species became threatened to the human practices by noticing their effects for their well-being. Consequently, among the species that were threatened include: Neocarea macrophylla Prance ex F.White (Gawasa), Sclerocarya birrea (A. Rich) Hochst. (Danya), Detarium microcarpum Harms. (Taura), Prosopis africana, (Kirya), Acacia africana, Acacia nilotica and Azadirachta indica. Hence, the major concern of this chapter is to assess some of the threatened species found in the Sahel region, Nigeria and to highlight the valuable medicinal plants at risk of extinction according to the guidelines of the International Union for the Conservation of Nature (IUCN).

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Section: Medicinal Values Of Neemmentioning

confidence: 99%

Noteworthy Threatened Plant Species in the Sahel Region, Nigeria

Salihu¹,

Go²

2021

Endangered Plants

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Pharmacophoric Evaluation of Compounds Isolated from GC-MS Analytical Method of Aqueous Extract of Azadirachta indica Leaves

Nagesh

Kannan

2023

Biomed. Pharmacol. J.

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The majority of current pharmaceuticals are derived from traditional plants; one of these, Azadirachta indica, also known as neem, has a variety of therapeutic applications ranging from simple infections to cancer. All of these pharmacological effects are due to the secondary metabolites present in the various plant parts. Diverse researchers made numerous attempts to identify the active ingredients using techniques such as Gas Chromatography-Mass Spectrometry (GC-MS), High-performance liquid chromatography (HPLC), and High performance thin-layer chromatography (HPTLC), among others. The GC-MS technique is used to isolate various secondary metabolites from the leaves of an aqueous extract of A.indica. The isolated compounds were analysed for their pharmacokinetics and pharmacodynamics properties using software such as SWISSADME, OPENBABEL, Swiss target prediction, etc. The aqueous extract of A.indica yielded 13 compounds, but only 5 compounds showed the highest number of hits; those with the highest concentration were chosen to obtain the pharmacodynamic, pharmacokinetic, and toxicological profiles. All five compounds are non-toxic and can be administered orally, and molecules with specific properties are capable of modulating a variety of proteins, including some enzymes. Based on this information, we can assume that these molecules can be used as "hit" or "lead" molecules in preclinical studies.

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In-silico Investigation and ADMET Prediction of Potential Antifungal Phytochemicals against Lanosterol 14-Alpha Demethylase Inhibitors

A. Shinde,

J. Mhetar,

G. Parit

et al. 2024

AJPR

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Mycosis is a chronic infectious disorder caused by various fungi affecting about 5% of the worldwide population. Pathogenesis involves the primary contact or inhalational roué for transmission. The infection is caused by to encoding of CYP450 enzyme Lanosterol 14-alpha demethylase. Numerous inhibitors are already used in clinical settings as therapeutic targets. A human lanosterol protein target (PDB ID: 6UEZ) and phytochemicals ligand library were used in a molecular docking simulation to perform docking simulation and ADMET studies on selected phytochemicals against human lanosterol protein receptor for drug discovery against lanosterol 14-alpha demethylase. The protein's crystal structure was retrieved and developed from the protein data repository with the aid of Biovia Discovery Studio. The phytochemicals' chemical structures were generated using Open Babel and VConf software after being downloaded from the NCBI PubChem database. PyRx was used to do molecular docking on Autodock Vina. SwissADME and pkCSM web servers were used to compute the best-performing compounds' ADMET characteristics. The findings demonstrated that taraxasterol exhibits a greater binding affinity. According to the findings, these compounds may be able to create anti-fungal activity, have decreased toxicity, and have easy absorbability at the tissue site, according to an ADME analysis. As a result, these substances can be examined in more in vitro research and could play a key role in developing a potential medicine to treat fungus infections.

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Erratum for Nagesh et al., Phytochemical analysis and docking study of compounds present in a polyherbal preparation used in the treatment of dermatophytosis

Abstract: Volume 3, no. 4, 6-14, 2017, DOI: 10.29252/cmm.3.4.6. This erratum adds the primary affiliation of Simhadri VSDNA Nagesh, a Research scholar. The affiliation line should appear as shown above.

Cited by 3 publications

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Noteworthy Threatened Plant Species in the Sahel Region, Nigeria

Noteworthy Threatened Plant Species in the Sahel Region, Nigeria

Pharmacophoric Evaluation of Compounds Isolated from GC-MS Analytical Method of Aqueous Extract of Azadirachta indica Leaves

In-silico Investigation and ADMET Prediction of Potential Antifungal Phytochemicals against Lanosterol 14-Alpha Demethylase Inhibitors

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