ERRATUM: Homeostatic plasticity in human motor cortex demonstrated by two consecutive sessions of paired associative stimulation

Muller, Jeff; Orekhov, Yuriy; Liu, Yali; Ziemann, Ulf

doi:10.1111/j.1460-9568.2007.05790.x

Cited by 4 publications

(5 citation statements)

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“…In several other investigations individual ISIs have been calculated by means of the SEP N20 latency (e.g., Ziemann et al, 2004; Muller et al, 2007; Potter-Nerger et al, 2009; Ilic et al, 2011; Voytovych et al, 2012). The ISIs calculated by Ilic et al (2011) on this basis (i.e., N20 latency minus 5 ms) yielded values longer than the conventional 10 ms interval used to induce inhibition (13.7–16 ms).…”

Section: Timing Dependency In Pasmentioning

confidence: 99%

Modulation of human corticospinal excitability by paired associative stimulation

Carson

Kennedy

2013

Front. Hum. Neurosci.

131

141

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Paired Associative Stimulation (PAS) has come to prominence as a potential therapeutic intervention for the treatment of brain injury/disease, and as an experimental method with which to investigate Hebbian principles of neural plasticity in humans. Prototypically, a single electrical stimulus is directed to a peripheral nerve in advance of transcranial magnetic stimulation (TMS) delivered to the contralateral primary motor cortex (M1). Repeated pairing of the stimuli (i.e., association) over an extended period may increase or decrease the excitability of corticospinal projections from M1, in manner that depends on the interstimulus interval (ISI). It has been suggested that these effects represent a form of associative long-term potentiation (LTP) and depression (LTD) that bears resemblance to spike-timing dependent plasticity (STDP) as it has been elaborated in animal models. With a large body of empirical evidence having emerged since the cardinal features of PAS were first described, and in light of the variations from the original protocols that have been implemented, it is opportune to consider whether the phenomenology of PAS remains consistent with the characteristic features that were initially disclosed. This assessment necessarily has bearing upon interpretation of the effects of PAS in relation to the specific cellular pathways that are putatively engaged, including those that adhere to the rules of STDP. The balance of evidence suggests that the mechanisms that contribute to the LTP- and LTD-type responses to PAS differ depending on the precise nature of the induction protocol that is used. In addition to emphasizing the requirement for additional explanatory models, in the present analysis we highlight the key features of the PAS phenomenology that require interpretation.

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Section: Timing Dependency In Pasmentioning

confidence: 99%

Modulation of human corticospinal excitability by paired associative stimulation

Carson

Kennedy

2013

Front. Hum. Neurosci.

131

141

View full text Add to dashboard Cite

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“…Similarly, the largest and most consistent facilitation of M1 via neuromodulation is induced when cortical stimulation is applied 2-5 ms after the arrival of the Estim-induced sensory signal at the somatosensory cortex (Stefan, 2000;Stefan et al, 2002;Ziemann, 2004;Müller et al, 2007). With Estim, the arrival time can be determined for each individual with the first negative peak around 20 ms latency (N20) in somatosensory evoked potentials recorded through electroencephalography (EEG) (Wolters et al, 2003;Müller et al, 2007). The critical issue is that Estim-PAS can induce inhibition if the brain is stimulated 5-10 ms before the arrival of the sensory signal (Wolters et al, 2003;Ziemann, 2004;Müller et al, 2007).…”

Section: Characterization Of Mstim-induced Neuromodulationmentioning

confidence: 95%

“…At the synaptic level, LTP can be induced only when the postsynaptic neurons are excited immediately after the excitation of presynaptic neurons. Similarly, the largest and most consistent facilitation of M1 via neuromodulation is induced when cortical stimulation is applied 2-5 ms after the arrival of the Estim-induced sensory signal at the somatosensory cortex (Stefan, 2000;Stefan et al, 2002;Ziemann, 2004;Müller et al, 2007). With Estim, the arrival time can be determined for each individual with the first negative peak around 20 ms latency (N20) in somatosensory evoked potentials recorded through electroencephalography (EEG) (Wolters et al, 2003;Müller et al, 2007).…”

Section: Characterization Of Mstim-induced Neuromodulationmentioning

confidence: 99%

“…With Estim, the arrival time can be determined for each individual with the first negative peak around 20 ms latency (N20) in somatosensory evoked potentials recorded through electroencephalography (EEG) (Wolters et al, 2003;Müller et al, 2007). The critical issue is that Estim-PAS can induce inhibition if the brain is stimulated 5-10 ms before the arrival of the sensory signal (Wolters et al, 2003;Ziemann, 2004;Müller et al, 2007). For example, Wolters et al previously utilized the N20-P25 somatosensory evoked potential (SSEP) complex to evaluate the effect of PAS timing on neural plasticity (Wolters et al, 2005).…”

Section: Characterization Of Mstim-induced Neuromodulationmentioning

confidence: 99%

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Statistical Inter-stimulus Interval Window Estimation for Transient Neuromodulation via Paired Mechanical and Brain Stimulation

et al. 2020

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“…Task-set switching (Meiran et al, 2000;Monsell, 2003;Dreisbach and Goschke, 2004;Müller et al, 2007b) was used as a measure of cognitive flexibility. On each trial, subjects had to respond to one of two different digits (randomly drawn from 1 to 8) presented simultaneously one above the other in different colors (red, blue or green).…”

Section: Endpointsmentioning

confidence: 99%

Effects of Ginkgo biloba extract EGb 761® on cognitive control functions, mental activity of the prefrontal cortex and stress reactivity in elderly adults with subjective memory impairment – a randomized double‐blind placebo‐controlled trial

Beck

Ruge

Schindler

et al. 2016

Human Psychopharmacology

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ObjectiveCognitive control as well as stress reactivity is assumed to depend on prefrontal dopamine and decline with age. Because Ginkgo biloba extract EGb761® increases prefrontal dopamine in animals, we assessed its effects on cognitive functions related to prefrontal dopamine.MethodsEffects of 240‐mg EGb761® daily on task‐set‐switching, response‐inhibition, delayed response, prospective‐memory, task‐related fMRI‐BOLD‐signals and the Trier Social Stress‐Test were explored in a randomized, placebo‐controlled, double‐blind pilot‐trial in 61 elderly volunteers with subjective memory impairment.† ResultsBaseline‐fMRI‐data showed BOLD‐responses in regions commonly activated by the specific tasks. Task‐switch‐costs decreased with EGb761® compared to placebo (ANOVA‐interaction: Group × Time × Switch‐Costs p = 0.018, multiple tests uncorrected), indicating improved cognitive flexibility. Go–NoGo‐task reaction‐times corrected for error‐rates indicated a trend for improved response inhibition. No treatment effects were found for the delayed response and prospective‐memory tasks and fMRI‐data. A non‐significant trend indicated a potentially accelerated endocrine stress‐recovery. EGb761® was safe and well tolerated.ConclusionWe observed indications for improved cognitive flexibility without changes in brain activation, suggesting increased processing efficiency with EGb761®. Together with a trend for improved response inhibition results are compatible with mild enhancement of prefrontal dopamine. These conclusions on potential beneficial effect of EGb761® on prefrontal dopaminergic functions should be confirmed by direct measurements. © 2016 The Authors. Human Psychopharmacology: Clinical and Experimental published by John Wiley & Sons, Ltd.

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ERRATUM: Homeostatic plasticity in human motor cortex demonstrated by two consecutive sessions of paired associative stimulation

Cited by 4 publications

References 1 publication

Modulation of human corticospinal excitability by paired associative stimulation

Modulation of human corticospinal excitability by paired associative stimulation

Statistical Inter-stimulus Interval Window Estimation for Transient Neuromodulation via Paired Mechanical and Brain Stimulation

Effects of Ginkgo biloba extract EGb 761® on cognitive control functions, mental activity of the prefrontal cortex and stress reactivity in elderly adults with subjective memory impairment – a randomized double‐blind placebo‐controlled trial

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