Erratum: Microbial transformation of isopinocampheol and caryophyllene oxide

Noma, Yoshiaki; Hashimoto, Toshihiro; Uehara, Shinya; Asakawa, Yoshinori

doi:10.1002/ffj.2002

Cited by 2 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alpha-pinene contributes to the distinctive scent of fresh pine needles, conifers, and sage. It is also present in various herbs, including parsley, rosemary, basil, and dill, making it the most prevalent natural terpenes [ 138 ]. Studies have demonstrated its antioxidant activity [ 139 ] and anti-inflammatory effects in human chondrocytes [ 140 , 141 ], suggesting its potential for anti-osteoarthritic activity [ 141 ].…”

Section: Anti-neuroinflammatory Activity Of Phytochemicals In ...mentioning

confidence: 99%

The Neurotherapeutic Arsenal in Cannabis sativa: Insights into Anti-Neuroinflammatory and Neuroprotective Activity and Potential Entourage Effects

Al-Khazaleh,

Zhou,

Bhuyan

et al. 2024

Molecules

View full text Add to dashboard Cite

Cannabis, renowned for its historical medicinal use, harbours various bioactive compounds—cannabinoids, terpenes, and flavonoids. While major cannabinoids like delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) have received extensive scrutiny for their pharmacological properties, emerging evidence underscores the collaborative interactions among these constituents, suggesting a collective therapeutic potential. This comprehensive review explores the intricate relationships and synergies between cannabinoids, terpenes, and flavonoids in cannabis. Cannabinoids, pivotal in cannabis’s bioactivity, exhibit well-documented analgesic, anti-inflammatory, and neuroprotective effects. Terpenes, aromatic compounds imbuing distinct flavours, not only contribute to cannabis’s sensory profile but also modulate cannabinoid effects through diverse molecular mechanisms. Flavonoids, another cannabis component, demonstrate anti-inflammatory, antioxidant, and neuroprotective properties, particularly relevant to neuroinflammation. The entourage hypothesis posits that combined cannabinoid, terpene, and flavonoid action yields synergistic or additive effects, surpassing individual compound efficacy. Recognizing the nuanced interactions is crucial for unravelling cannabis’s complete therapeutic potential. Tailoring treatments based on the holistic composition of cannabis strains allows optimization of therapeutic outcomes while minimizing potential side effects. This review underscores the imperative to delve into the intricate roles of cannabinoids, terpenes, and flavonoids, offering promising prospects for innovative therapeutic interventions and advocating continued research to unlock cannabis’s full therapeutic potential within the realm of natural plant-based medicine.

show abstract

Section: Anti-neuroinflammatory Activity Of Phytochemicals In ...mentioning

confidence: 99%

The Neurotherapeutic Arsenal in Cannabis sativa: Insights into Anti-Neuroinflammatory and Neuroprotective Activity and Potential Entourage Effects

Al-Khazaleh,

Zhou,

Bhuyan

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

“…Alpha-pinene contributes to the distinctive scent of fresh pine needles, conifers, and sage. It is also present in various herbs, including parsley, rosemary, basil, and dill, making it the most prevalent natural terpenes (Noma et al, 2010). Studies have demonstrated its antioxidant activity (Wang et al, 2008) and anti-inflammatory effects in human chondrocytes (Neves et al, 2010;Rufino et al, 2014), suggesting its potential for anti-osteoarthritic activity (Rufino et al, 2014).…”

Section: Terpenesmentioning

confidence: 99%

Elucidating the Neuroinflammatory and Neuroprotective Activity of Phytochemicals in Cannabis sativa and their potential Entourage Effects

Al-Khazaleh,

Zhou,

Bhuyan

et al. 2023

Preprint

View full text Add to dashboard Cite

Cannabis, renowned for its historical medicinal use, harbours various bioactive compounds—cannabinoids, terpenes, and flavonoids. While major cannabinoids like THC and CBD have received extensive scrutiny for their pharmacological properties, emerging evidence underscores the collaborative interactions among these constituents, suggesting a collective therapeutic potential. This comprehensive review explores the intricate relationships and synergies between cannabinoids, terpenes, and flavonoids in cannabis. Cannabinoids, pivotal in cannabis's bioactivity, exhibit well-documented analgesic, anti-inflammatory, and neuroprotective effects. Terpenes, aromatic compounds imbuing distinct flavours, not only contribute to cannabis's sensory profile but also modulate cannabinoid effects through diverse molecular mechanisms. Flavonoids, another cannabis component, demonstrate anti-inflammatory, antioxidant, and neuroprotective properties, particularly relevant to neuroinflammation. The entourage hypothesis posits that combined cannabinoid, terpene, and flavonoid action yields synergistic or additive effects, surpassing individual compound efficacy. Recognizing the nuanced interactions is crucial for unravelling cannabis's complete therapeutic potential. Tailoring treatments based on the holistic composition of cannabis strains allows optimization of therapeutic outcomes while minimizing potential side effects. This review underscores the imperative to delve into the intricate roles of cannabinoids, terpenes, and flavonoids, offering promising prospects for innovative therapeutic interventions and advocating continued research to unlock cannabis's full therapeutic potential within the realm of natural plant-based medicine.

show abstract

Erratum: Microbial transformation of isopinocampheol and caryophyllene oxide

Abstract: The biotransformation of (+)-isopinocampheol and (-)-isopinocampheol and (6R)-(-)-caryophyllene oxide was carried out by

Cited by 2 publications

References 15 publications

The Neurotherapeutic Arsenal in Cannabis sativa: Insights into Anti-Neuroinflammatory and Neuroprotective Activity and Potential Entourage Effects

The Neurotherapeutic Arsenal in Cannabis sativa: Insights into Anti-Neuroinflammatory and Neuroprotective Activity and Potential Entourage Effects

Elucidating the Neuroinflammatory and Neuroprotective Activity of Phytochemicals in Cannabis sativa and their potential Entourage Effects

Contact Info

Product

Resources

About