Erratum to: A fibrin/hyaluronic acid hydrogel for the delivery of mesenchymal stem cells and potential for articular cartilage repair

Snyder, Timothy N; Madhavan, Krishna; Intrator, Miranda; Dregalla, Ryan C.; Park, Dae‐Won

doi:10.1186/1754-1611-8-27

Cited by 2 publications

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“…Figure1shows the spectra of HA and modified HA-NH2, the signals from 3.43 to 3.87 ppm were assigned to the protons on the sugar rings[56,57]. The methyl (-CH3) protons of the N-acetyl group of HA and HA-NH2 showed a signal at 2.06 ppm (label a).…”

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confidence: 99%

Developing a novel bioink from hyaluronic acid-alginate-silk fibroin (HA- Alg-SF) for cartilage 3D printing

Nguyen¹

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In the development of a bioink for cartilage 3D printing, Hyaluronic acid (HA), Alginate (Alg) were modified into amine-hyaluronic acid (HA-NH2) and aldehyde alginate (Alg-CHO). Magnetic Nuclear Resonance (NMR) and Fourier Transform Infrared Spectroscopy (FTIR) confirmed the successful modification of HA-NH2 and Alg-CHO. The hydrogel HA-Alg was crosslinked as a result of Schiff's base reaction, between primary amines and aldehydes to form imine bonds. By varying volume ratios, the optimal hydrogel HA-Alg (5:5) exhibited its printability, biocompatibility, and functionality as a bioink for cartilage tissue. HA-Alg (5:5) was printable with a custom-made extrusion 3D printer, had slow degradation, shear-thinning behavior, supported cell viability, proliferation, and chondrogenic differentiation. To prove that HA-Alg could act as a platform for entrapment of macromolecules, Silk fibroin (SF) which is a biocompatible protein was loaded into HA-Alg formulation to develop HA-Alg-SF hydrogel. The results showed that HA-Alg-SF hydrogel adapted to 3D printing, and promoted cartilage tissue formation. The addition of SF did not compromise the printability and cell viability of HA-Alg-SF hydrogel comparing to HA-Alg hydrogel, which suggested that HA-Alg hydrogel could be an interpenetrating polymer network (IPN) for loading other proteins, and growth factors for further applications.

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Developing a novel bioink from hyaluronic acid-alginate-silk fibroin (HA- Alg-SF) for cartilage 3D printing

Nguyen¹

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Injectable Hyaluronic Acid Hydrogels Enriched with Platelet Lysate as a Cryostable Off-the-Shelf System for Cell-Based Therapies

Neves

Babo

Gonçalves

et al. 2017

Regen. Eng. Transl. Med.

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Erratum to: A fibrin/hyaluronic acid hydrogel for the delivery of mesenchymal stem cells and potential for articular cartilage repair

Cited by 2 publications

References 1 publication

Developing a novel bioink from hyaluronic acid-alginate-silk fibroin (HA- Alg-SF) for cartilage 3D printing

Developing a novel bioink from hyaluronic acid-alginate-silk fibroin (HA- Alg-SF) for cartilage 3D printing

Injectable Hyaluronic Acid Hydrogels Enriched with Platelet Lysate as a Cryostable Off-the-Shelf System for Cell-Based Therapies

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