Erratum to Cinnarizine in refractory migraine prophylaxis: efficacy and tolerability. A comparison with sodium valproate

Abstract

The first author's given name and family name were transposed. His correct name is Mansoureh Togha.

The effects of cinnarizine versus sodium valproate in migraine prophylaxis

“…Patients' demographic information and characteristics of migraine episodes were not significantly different between the two groups. The proportion of patients who experienced one or more adverse events and the most common adverse events in both the groups were comparable with findings of most of the previous studies [10,11,14,15]. Somnolence was the most frequent side effect we have observed, in clinical setting this side effect could be reduced by the assumption of the entire dose of cinnarizine at the night sleep time.…”

“…Amelin et al [14] reported a major reduction in migraine attacks frequency by studying vertigolytic effect of cinnarizine in a group of patients with migraine. Togha et al [10,15] in an open-label, double-blind, parallel-group clinical trial reported significant improvement in migraine headache frequency, duration and intensity after administration of 25-mg cinnarizine every 8 hours; however, there were some significant side effects including dry mouth, fatigue, somnolence, nausea, constipation and hypotension [8]. Togha et al [15] in a clinical trial compared the effect of cinnarizine versus valproate in refractory migraine prophylaxis and showed that cinnarizine is an effective and safe prophylactic agent even in severe cases of migraine headache.…”

“…Togha et al [10,15] in an open-label, double-blind, parallel-group clinical trial reported significant improvement in migraine headache frequency, duration and intensity after administration of 25-mg cinnarizine every 8 hours; however, there were some significant side effects including dry mouth, fatigue, somnolence, nausea, constipation and hypotension [8]. Togha et al [15] in a clinical trial compared the effect of cinnarizine versus valproate in refractory migraine prophylaxis and showed that cinnarizine is an effective and safe prophylactic agent even in severe cases of migraine headache. Several clinical practices have suggested that lower doses of certain drugs, such as warfarin, propranolol, tricyclic antidepressants and lithium, should be prescribed for Iranians to reach optimal therapeutic levels of these drugs, compared with therapeutic doses required for Europeans and Americans [16][17][18][19].…”

“…In a similar way, we assumed that low-dose cinnarizine might also be effective in migraine prophylaxis. Several anticonvulsants have also been investigated for the treatment of migraine and, in particular, sodium valproate have shown in clinical trials a reduction of at least 50% in headache frequency in about 30%-50% of patients [15,20]. The aim of this study was to compare efficacy of low-dose cinnarizine versus sodium valproate.…”

Possibilities to Use a Fixed Combination of Piracetam and Cinnarizine in Neurological Practice

“…Широко применяются в клинической практике с превентивной целью и блокаторы кальциевых каналов (флунаризин, циннаризин). В исследованиях при сравнении циннаризина с бета-блокатором (пропрано-лол) и антиконвульсантом (вальпроат) циннаризин про-демонстрировал сходную профилактическую эффектив-ность и переносимость [46,47].…”