Erratum to “Counteraction of HCV-Induced Oxidative Stress Concurs to Establish Chronic Infection in Liver Cell Cultures”

Anticoli, Simona; Amatore, Donatella; Matarrese, Paola; Angelis, Marta De; Palamara, Anna Teresa; Nencioni, Lucia; Ruggieri, Anna

doi:10.1155/2019/3712969

Cited by 1 publication

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data also showed that SOD, GSH-Px, and CAT were significantly decreased and that MDA was significantly increased in both chronic HBV and HCV infection as well as in inactive HBV carriers when compared with healthy subjects (p<0.05; Table 2). Our findings were consistent with other studies of HBV patients and support the presence of oxidative stress [5,7,33]. Our results confirm the contribution of oxidative stress as part of the pathophysiology of both HBV and HCV infections.…”

Section: Discussionsupporting

confidence: 93%

“…and liver injury, often resulting in chronic infection, which can be followed by cirrhosis and hepatocellular carcinoma [5,6]. The induction and subsequent production of reactive oxygen species cause DNA damage and affect the repair mechanism in HCV infections [7]. It has been determined that superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) antioxidants have key roles as cytoprotective enzymes with antioxidant and anti-inflammatory activity that prevents liver damage [8].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of serum proinflammatory cytokines, oxidative stress and some other biochemical markers in chronic viral hepatitis B and C infections

Bayraktar¹

2020

Int J Med Biochem

View full text Add to dashboard Cite

Evaluation of serum proinflammatory cytokines, oxidative stress, and other biochemical markers in chronic viral hepatitis B and C infections H epatitis B virus (HBV) and hepatitis C virus (HCV) infections are a global health problem that is endemic in Turkey. These viruses attack the liver and can cause both acute and chronic hepatitis infection [1, 2]. Chronic hepatitis infection presents a major risk for the development of hepatocellular carcinoma [2, 3. 4]. These viruses directly induce oxidative stress Objectives: Infection with the hepatitis B virus (HBV) or the hepatitis C virus (HCV) results in inflammatory responses, which can subsequently lead to severe progressive hepatic disease. Oxidative stress resulting from changes in the activity of antioxidant enzymes and cytokines and causing an excessive accumulation of reactive oxygen species has been identified as a key factor in the pathogenesis and progression of chronic liver inflammation and disease. Minerals such as zinc (Zn) and copper (Cu), which are part of the biochemical structure of some antioxidant enzymes, also play a part in the complicated pathogenesis of HBV and HBC infections. The aim of this study was to investigate the effects of chronic viral HBV and HCV infection on the status of some serum cytokines, antioxidant enzymes, lipid peroxidation, and serum Zn and Cu levels, and to determine if there was any relationship between them. Methods: A total of 78 patients with positive clinical and serological markers of HBV or HCV infection were included: 40 chronic HBV-positive patients, 30 inactive HBV carriers, and 8 chronic HCV-positive patients. Thirty healthy subjects were also included in the study as a control group. The level of serum cytokines tumor necrosis factor-α (TNF-α), interleukin-1β, (IL-1 β), interleukin-2R (IL-2R), interleukin-6 (IL-6), and interleukin-8 (IL-8) was analyzed with a chemiluminescent enzyme immunometric test, the activity of antioxidant enzymes superoxide dismutase (SOD), phospholipid hydroperoxide glutathione peroxidase (GSH-Px), and catalase (CAT) was measured in erythrocytes, and the malondialdehyde (MDA) level was measured in plasma using a fluorescence spectrophotometric method. The serum Zn and Cu concentration was measured with a flame atomic absorption spectrophotometer. Results: Serum cytokine (TNF-α, IL-2R, IL-6, and IL-8) levels were significantly higher in both the HBV-and HCV-positive patient groups when compared with the control group (p<0.05). No statistically significant difference was found in IL-1β values between chronic HBV patients and inactive HBV carriers (p>0.05). Erythrocyte SOD, GSH-Px, and CAT activity, and the serum Zn level were low in both HBV and HCV patients (p<0.05), whereas the plasma MDA and serum Cu levels were found to be significantly elevated (p<0.05). Conclusion: An impaired oxidative stress reaction and increased proinflammatory cytokines were observed in patients infected with chronic HBV or HCV. Chronic viral hepatitis infection was also observed to affect the homeostasis of...

show abstract

Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%