Erratum to: Double Bond Stereochemistry Influences the Susceptibility of Short‐Chain Isoprenoids and Polyprenols to Decomposition by Thermo‐Oxidation

Sosińska, Ewa; Klimczak, Urszula; Komaszyło, Joanna; Derewiaka, Dorota; Obiedziński, M.; Kania, Magdalena; Danikiewicz, Witold; Świeżewska, Ewa

doi:10.1007/s11745-015-4013-0

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“…Previously, data have shown a rapid decrease of dolichol in erythroclastic organs after the administration of phenylhydrazine, and it has been suggested that this depletion might be attributed to a freeradical mediate decomposition of dolichol by phagocytic cells during erythrophagocytosis [53]. Furthermore, a study showed that short-and long-chain polyisoprenoid alcohols are prone to thermo-oxidation, and it has been speculated that oxidized isoprenoids might be formed in the cells because of chemical processes driven by oxidative agents (e.g., reactive oxygen species) [54]. This hypothesis has recently been substantiated by experimental data indicating the susceptibility of polyisoprenoid alcohols to various oxidizing agents for the first time [55].…”

Section: Discussionmentioning

confidence: 99%

Dolichol: A Component of the Cellular Antioxidant Machinery

Cavallini

Sgarbossa

Parentini

et al. 2016

Lipids

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Dolichol, an end product of the mevalonate pathway, has been proposed as a biomarker of aging, but its biological role, not to mention its catabolism, has not been fully understood. UV-B radiation was used to induce oxidative stress in isolated rat hepatocytes by the collagenase method. Effects on dolichol, phospholipid-bound polyunsaturated fatty acids (PL-PUFA) and known lipid soluble antioxidants [coenzyme Q (CoQ) and α-tocopherol] were studied. The increase in oxidative stress was detected by a probe sensitive to reactive oxygen species (ROS). Peroxidation of lipids was assessed by measuring the release of thiobarbituric acid reactive substances (TBARS). Dolichol, CoQ, and α-tocopherol were assessed by high-pressure liquid chromatography (HPLC), PL-PUFA by gas-liquid chromatography (GC). UV-B radiation caused an immediate increase in ROS as well as lipid peroxidation and a simultaneous decrease in the levels of dolichol and lipid soluble antioxidants. Decrease in dolichol paralleled changes in CoQ levels and was smaller to that in α-tocopherol. The addition of mevinolin, a competitive inhibitor of the enzyme 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoAR), magnified the loss of dolichol and was associated with an increase in TBARS production. Changes in PL-PUFA were minor. These findings highlight that oxidative stress has very early and similar effects on dolichol and lipid soluble antioxidants. Lower levels of dolichol are associated with enhanced peroxidation of lipids, which suggest that dolichol may have a protective role in the antioxidant machinery of cell membranes and perhaps be a key to understanding some adverse effects of statin therapy.

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Section: Discussionmentioning

confidence: 99%