Erratum to: ‘Effectiveness of biomarker-based exclusion of ventilator-acquired pneumonia to reduce antibiotic use (VAPrapid-2): study protocol for a randomised controlled trial’

Purpose of review Although pneumonia, either community or hospital-acquired, is the most frequent severe respiratory infection, it is an infection difficult to diagnose. At present, the diagnosis of pneumonia relies on a combination of clinical, radiologic, and microbiologic criteria. However, these criteria are far from perfect leading to uncertainty in the diagnosis, risk stratification, and choice of antibiotic therapy. Biomarkers have been used to bring additional information in this setting. Recent findings The aim of this review is to provide a clear overview of the current evidence for biomarkers to distinguish between patients in several clinical scenarios: to exclude pneumonia in order to withhold antibiotics, to identify the causative pathogen to target antimicrobial treatment, to identify phenotypes of inflammatory response to facilitate adjunctive treatments, to stratify the risk of severe pneumonia and provide the adequate level of care, and to monitor treatment response and de-escalate antibiotic therapy. Summary In recent years the number of new biomarkers increased markedly in different areas like pathogen identification or host response. Although far from the ideal, there are several promising areas that could represent true evolutions in the management of pneumonia, in the near future.

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New biomarkers for respiratory infections

Póvoa

Coelho

Bos

2020

Current Opinion in Pulmonary Medicine

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The role of proinflammatory and anti-inflammatory cytokines in bacterial pneumonia. Review

Zinina¹,

Царенко

Logunov

et al. 2021

Annals of Critical Care

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Нозокомиальная пневмония -частая причина смертности пациентов в отделениях реанимации и интенсивной терапии (ОРИТ). Эффективность лечения зависит от выбора режима антибиотикотерапии. Изменение концентрации цитокинов в крови может являться чувствительным предиктором исхода нозокомиальной пневмонии и ответа на антибактериальную терапию. Анализ литературы показал, что по запросу «pneumonia», «cytokines», «biomarkers» в базе данных Pubmed можно обнаружить 1062 публикации. При сужении поиска с использованием ключевых слов «nosocomial pneumonia», «cytokines» приведено 212 источников. Дополнительный поиск литературных данных о конкретных цитокинах и их роли при пневмонии позволяет обнаружить еще 258 публикаций. Результаты экспериментальных и клинических работ указывают на прогностическую ценность цитокинов при бактериальной пневмонии. В обзоре подробно рассмотрены механизмы развития иммунной реакции и воспаления при пневмонии, связанные с ней цитокины и исследования их практического применения. Рассмотрено значение интерлейкинов, интерферонов, белков суперсемейства фактора некроза опухолей, матриксных металлопротеиназ, колониестимулирующих факторов, хемокинов, противовоспалительных цитокинов. Многие из

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Erratum to: ‘Effectiveness of biomarker-based exclusion of ventilator-acquired pneumonia to reduce antibiotic use (VAPrapid-2): study protocol for a randomised controlled trial’

Cited by 2 publications

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New biomarkers for respiratory infections

New biomarkers for respiratory infections

The role of proinflammatory and anti-inflammatory cytokines in bacterial pneumonia. Review

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