Erratum to: Effectiveness of initiating extrafine-particle versus fine-particle inhaled corticosteroids as asthma therapy in the Netherlands

Molen, Thys van der; Postma, Dirkje S.; Martin, Richard J.; Herings, Ron M. C.; Overbeek, Jetty A.; Thomas, Victoria; Miglio, Cristiana; Dekhuijzen, Richard; Roche, N.; Guilbert, Theresa W.; Israel, Elliot; Aalderen, Wim van; Hillyer, Elizabeth V.; Rysewyk, Simon van; Price, David

doi:10.1186/s12890-016-0270-9

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“…Recent technological advances have paved the way for developing new drug delivery systems and formulations that improve drug deposition and overall efficacy, safety, and effectiveness. Real-world studies have demonstrated that extra-fine formulations of ICS, ICS and LABA, and long-acting muscarinic antagonists (LAMA) have a much better likelihood of resulting in asthma control, even in patients with SAD phenotypes, and including those with obese asthma [87][88][89][90][91][92][93][94]. A study conducted recently reported that individuals with asthma who used ICS had an increased risk of developing higher BMI trajectories over time, and they also required more antidiabetic and cholesterol-lowering medications [95].…”

Section: The Impact Of Sad On Asthma Management In Patients With Obesitymentioning

confidence: 99%

Small airway dysfunction and obesity in asthmatic patients: a dangerous liaison?

Pepys

Lombardi

Comberiati

et al. 2023

Explor Asthma Allergy

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Asthma is a chronic condition characterized by inflammation throughout the entire bronchial airways. Recent findings suggest that ventilation inhomogeneity and small airway dysfunction (SAD) play a particularly significant role in asthma development and clinical manifestations. Obesity is a considerable risk factor for asthma development and morbidity in children and adults. A growing body of evidence suggests that SAD is linked to more severe asthma and poor asthma control in obese patients. However, the knowledge about the relationship between peripheral airway compromise and obesity in asthma is limited, mainly because of the historical lack of access to non-invasive assessment methods for studying SAD. Conventional lung function measurements, like spirometry, cannot accurately assess small airway function. However, in recent years, new specialized tests available in outpatient settings have been found to distinguish SAD from large airway obstruction more accurately compared to spirometry. Therefore, understanding the degree of peripheral airway implication in the underlying pathology is critical for effective asthma control and therapeutic decisions. This review highlights recent findings on the impact of SAD on asthma patients who are obese. Additionally, it explores how new diagnostic methods, such as impulse oscillometry (IOS), may be used in outpatient settings to detect small airway impairment in obese asthma at an early stage, potentially leading to improved asthma treatment.

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Section: The Impact Of Sad On Asthma Management In Patients With Obesitymentioning

confidence: 99%

Small airway dysfunction and obesity in asthmatic patients: a dangerous liaison?

Pepys

Lombardi

Comberiati

et al. 2023

Explor Asthma Allergy

View full text Add to dashboard Cite

show abstract

Erratum to: Effectiveness of initiating extrafine-particle versus fine-particle inhaled corticosteroids as asthma therapy in the Netherlands

Cited by 1 publication

References 1 publication

Small airway dysfunction and obesity in asthmatic patients: a dangerous liaison?

Small airway dysfunction and obesity in asthmatic patients: a dangerous liaison?

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