Erratum to: Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway

Ying, Tsung Ho; Yang, Shun Fa; Tsai, Su Ju; Hsieh, Shu Ching; Huang, Yi; Bau, Da Tian; Hsieh, Yi‐Hsien

doi:10.1007/s00204-011-0796-9

Cited by 2 publications

(2 citation statements)

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“…Fisetin is a naturally occurring flavonoid ( 31 ) with antioxidant, antidiabetic, anti-inflammatory ( 32 ), anticancer ( 21 , 33 ) and neuroprotective properties ( 34 ). Fisetin promotes the apoptosis of several cancer cell types by constraining COX-2 ( 35 ), impeding the Wnt/EGFR signaling pathway ( 36 ), strengthening caspase-3 cascade reactions, boosting the caspase-3/8 dependent pathway, and amplifying the activity of Ca 2+ and caspase-3-dependent endonuclease ( 37 ). Fisetin has been shown to serve a role in RCC development.…”

Section: Discussionmentioning

confidence: 99%

Fisetin enhances cisplatin sensitivity in renal cell carcinoma via the CDK6/PI3K/Akt/mTOR signaling pathway

Jiang,

Liang,

et al. 2024

Oncol Lett

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Cisplatin resistance is ubiquitous among patients with renal cell carcinoma (RCC). The present study assessed the role of fisetin in regulating cisplatin sensitivity and increasing the efficacy of chemotherapy for patients with RCC. Cell Counting Kit-8 and colony formation assays were used to assess the proliferation of RCC cells after fisetin and cisplatin treatment. The mRNA expression levels of cyclin-dependent kinase (CDK)6 were evaluated using reverse transcription-quantitative PCR. The expression levels of CDK6 and key proteins of the PI3K/Akt/mTOR signaling pathway were assessed using western blotting. The present study demonstrated that fisetin inhibited the proliferation and colony-forming ability of RCC cells, and induced apoptosis and cell cycle arrest in a dose-dependent manner. Additionally, fisetin enhanced the antineoplastic effects of cisplatin, as demonstrated by the increase in proliferation inhibition and apoptosis promotion after fisetin and cisplatin combination treatment. Furthermore, fisetin regulated the PI3K/Akt/mTOR signaling pathway through CDK6 inhibition, which enhanced cisplatin sensitivity. Overexpression of CDK6 neutralized the positive effects of fisetin on the improvement of cisplatin sensitivity in RCC cells. In conclusion, fisetin may enhance the sensitivity of RCC cells to cisplatin via the CDK6/PI3K/Akt/mTOR signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Fisetin enhances cisplatin sensitivity in renal cell carcinoma via the CDK6/PI3K/Akt/mTOR signaling pathway

Jiang,

Liang,

et al. 2024

Oncol Lett

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“…[16]. Fisetin-a strawberry and cucumber flavonoid-activates enzymes from the caspase family 3 and 9 [122]. Naringin-grapefruit flavonoid-leads to cell death by the induction of death receptors [33].…”

Section: Polyphenolsmentioning

confidence: 99%

Phytochemicals in Gynecological Cancer Prevention

Woźniak

Krajewski

Makuch

et al. 2021

IJMS

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Gynecological cancer confers an enormous burden among women worldwide. Accumulating evidence points to the role of phytochemicals in preventing cervical, endometrial, and ovarian cancer. Experimental studies emphasize the chemopreventive and therapeutic potential of plant-derived substances by inhibiting the early stages of carcinogenesis or improving the efficacy of traditional chemotherapeutic agents. Moreover, a number of epidemiological studies have investigated associations between a plant-based diet and cancer risk. This literature review summarizes the current knowledge on the phytochemicals with proven antitumor activity, emphasizing their effectiveness and mechanism of action in gynecological cancer.

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Erratum to: Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway

Abstract: The original publication of the article does not include the first author, Tsung-Ho Ying's additional affiliation. It is now given below for reference;

Cited by 2 publications

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Fisetin enhances cisplatin sensitivity in renal cell carcinoma via the CDK6/PI3K/Akt/mTOR signaling pathway

Fisetin enhances cisplatin sensitivity in renal cell carcinoma via the CDK6/PI3K/Akt/mTOR signaling pathway

Phytochemicals in Gynecological Cancer Prevention

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