Erratum to “Impact of COVID-19 on Future Ischemic Stroke Incidence” [eNeurologicalSci, 22C (2021) 100325]

Elfasi, Aisha; Echevarria, Franklin D.; Rodriguez, Ryan; Casul, Yoram A. Roman; Khanna, Anna; Mankowski, Robert T.; Simpkins, Alexis N

doi:10.1016/j.ensci.2021.100342

Cited by 3 publications

(4 citation statements)

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“…Furthermore, ischemic stroke was shown to develop in COVID-19 patients with or without co-morbidities. 64 Hence, stroke knowledge-based educational campaigns provided and led by health care personnel are of utmost importance during the pandemic.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Knowledge and attitude towards Stroke among the UAE population during the COVID-19 pandemic: A cross-sectional study

Ramadan,

Kharaba,

Ghemrawi

et al. 2023

F1000Res

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Background: Despite significant advancements in healthcare, the burden of stroke continues to rise in the developed world, especially during the COVID-19 pandemic. Association between COVID-19 infection and stroke is well established. Factors identified for the delay in presentation and management include a lack of awareness regarding stroke. We aimed to assess the general public knowledge and attitudes on stroke and stroke risk factors in the United Arab Emirates during the COVID-19 pandemic. Methods: A cross-sectional study was conducted between September 2021 and January 2022 among adults≥ 18 years old. Participants completed a self-administered questionnaire on sociodemographic characteristics and stroke knowledge and attitudes. Knowledge and attitude scores were calculated based on the number of correct responses. Linear regression analysis was performed to determine the factors related to knowledge and attitude towards stroke. Results: Of the 500 respondents, 69.4% were females, 53.4% were aged between 18 and 25, and nearly half were students (48.4%). The mean knowledge score was 13.66 (range 2-24). Hypertension (69%), smoking (63.2%), stress (56.4%) obesity/overweight (54.4%), and heart disease (53.6%) were identified as risk factors. Overall, the knowledge of signs/symptoms was suboptimal. The mean attitude score was 4.41 (range, 1-6); 70.2% would call an ambulance if someone were having a stroke. A monthly income of 11,000-50,000 AED and being a student were associated with positive knowledge. Being a non-health worker and lacking access to electronic media sources were associated with worse attitudes. Conclusion: Overall, we identified poor knowledge and suboptimal attitudes toward stroke. These findings reflect the need for effective public health approaches to improve stroke awareness, knowledge, and attitudes for effective prevention in the community. Presently, this is of utmost necessity, given the increased occurrence of stroke and its severity among COVID-19 patients.

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Section: Discussionmentioning

confidence: 99%

Assessment of Knowledge and attitude towards Stroke among the UAE population during the COVID-19 pandemic: A cross-sectional study

Ramadan,

Kharaba,

Ghemrawi

et al. 2023

F1000Res

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“…[1][2][3][4][5] Hypercoagulability, inflammation, cardiac dysfunction, and endothelial inflammation that occur during the infectious phase can lead to thrombotic events and thus cerebral ischemia. 6 Reported risks of stroke in COVID-19 have varied substantially across studies. 7 Most studies have focused on AIS incidence in patients diagnosed during or upon hospitalization.…”

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confidence: 99%

Risk of Acute Ischemic Stroke in Patients 65 and Older Is Early After COVID-19 Diagnosis

Simpkins

Lekoubou

2022

Neurology

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Associated acute and long-term medical complications of COVID-19 beyond respiratory illness include acute ischemic stroke (AIS). [1][2][3][4][5] Hypercoagulability, inflammation, cardiac dysfunction, and endothelial inflammation that occur during the infectious phase can lead to thrombotic events and thus cerebral ischemia. 6 Reported risks of stroke in COVID-19 have varied substantially across studies. 7 Most studies have focused on AIS incidence in patients diagnosed during or upon hospitalization. Unlike any other infectious disease in modern times and as a result of the need to trace and monitor for outbreaks to prevent the spread of COVID-19, a very large number of patients have been screened for COVID-19 at the time of hospital admission. This screening has identified both asymptomatic and symptomatic individuals with COVID-19, thus making it more difficult to determine whether and in whom COVID-19 may increase the risk of AIS and whether the association is true or incidental. In this issue of Neurology ® , Yang et al. 8 evaluated the estimated incidence rate ratio of AIS after COVID-19 infection in a known high-risk group-patients older than 65-and determined the time frame of highest risk of AIS associated with COVID-19 within this population. 8 The authors used inpatient and outpatient fee-for-service Medicare claims to identify 37,379 patients with COVID-19 and AIS between January 2019 and February 2021. 8 A pre-COVID diagnosis phase was used to account for unknown possible inoculation times and the time frame from COVID-19 billing diagnosis to stroke billing diagnosis code of up to 28 days was evaluated. 8 Applying the self-controlled case series method, the authors found that the incidence rate ratios (IRRs) were highest within 3 days of diagnosis of COVID-19, with an odds ratio of 10.3 (95% confidence interval 9.86-10.8), and that the estimated IRR was higher in those between ages 65 and 74 without a prior history of stroke. 8 By contrast, the association between stroke and COVID-19 was weaker 15-28 days after the initial diagnosis, suggesting that AIS rarely manifests as a long-term COVID-19 sequela in elderly patients. 8 Major strengths of the study are the inclusion of COVID-19 cases diagnosed both in outpatient and inpatient settings, the inclusion of a large number of patients from minority groups, and the use of robust statistical methods, such as the self-case-controlled case study, which has the advantage of implicit control for all fixed confounding effects. The authors made a great effort to verify that all assumptions were not violated, albeit with some modifications. They solidified the findings of their study by performing a number of sensitivity analyses.Interpretation of the study results should consider potential limitations, which were described by Yang et al. 8 These limitations stem primarily from the retrospective nature of the analysis and the use of administrative claims to identify cases of COVID-19 and AIS. As the Medicare data are updated monthly, cases of COVID-19 and death...

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“…What we do know is that patients at the highest risk of severe COVID-19 and stroke are those who already have cardiovascular risk factors. Therefore, despite the many challenges of managing primary and secondary stroke prevention during the pandemic, 3 the imperative to prioritize stroke prevention for those at risk has never been greater. 9,10 Fortunately, the meta-analysis results reported by Stefano et al offer reassurance that the frequency of postvaccine AIS is generally lower than the frequency of post-COVID AIS.…”

mentioning

confidence: 99%

“…2 Patients with COVID-19, particularly severe respiratory manifestations of the disease, were found early on to have evidence of a prothrombotic and proinflammatory state along with a propensity for cardiac dysfunction and stroke. 3 Stroke incidence in patients with COVID-19 was particularly higher in those with cardiovascular risk factors but could also occur in younger patients and those without preexisting traditional cardiovascular risk factors. 2 After the advent of COVID-19 vaccines, there emerged similarly concerning case reports of thrombotic events such as acute ischemic stroke (AIS) and cerebral venous thrombosis post-COVID-19 vaccine exposure, potentially resulting from thrombotic thrombocytopenia syndrome (TTS), cardiac dysfunction, or an excess of the vaccine-induced immune response.…”

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confidence: 99%

COVID-19 Exposures, Vaccines, and Acute Ischemic Stroke Risk

Simpkins

Cheng

2022

Neurology

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Erratum to “Impact of COVID-19 on Future Ischemic Stroke Incidence” [eNeurologicalSci, 22C (2021) 100325]

Cited by 3 publications

References 0 publications

Assessment of Knowledge and attitude towards Stroke among the UAE population during the COVID-19 pandemic: A cross-sectional study

Assessment of Knowledge and attitude towards Stroke among the UAE population during the COVID-19 pandemic: A cross-sectional study

Risk of Acute Ischemic Stroke in Patients 65 and Older Is Early After COVID-19 Diagnosis

COVID-19 Exposures, Vaccines, and Acute Ischemic Stroke Risk

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